(Q35923992)

English

An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy.

scientific article published on 15 February 2016

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8 March 2020

An Overview of Severe Acute Respiratory Syndrome-Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy (English)

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8 March 2020

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Thanigaimalai Pillaiyar

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8 March 2020

Vigneshwaran Namasivayam

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8 March 2020

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Manoj Manickam

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8 March 2020

Yoshio Hayashi

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8 March 2020

Sang-Hun Jung

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29 February 2016

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8 March 2020

Journal of Medicinal Chemistry

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8 March 2020

59

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8 March 2020

6595-6628

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8 March 2020

14

1 reference

Europe PubMed Central

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8 March 2020

Treatment of Wilson's disease with zinc. XVII: treatment during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3C-like proteinase from SARS coronavirus catalyzes substrate hydrolysis by a general base mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral zinc sulfate in the treatment of Behcet's disease: a double blind cross-over study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Virtual screening identification of novel severe acute respiratory syndrome 3C-like protease inhibitors and in vitro confirmation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of new tripeptide-type SARS-CoV 3CL protease inhibitors containing an electrophilic arylketone moiety.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe acute respiratory syndrome coronavirus 3C-like proteinase N terminus is indispensable for proteolytic activity but not for enzyme dimerization. Biochemical and thermodynamic investigation in conjunction with molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel coronavirus associated with severe acute respiratory syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conservation of substrate specificities among coronavirus main proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of new drugs for an old target: the penicillin binding proteins.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel drug scaffolds for inhibition of SARS-CoV 3-Chymotrypsin-like protease using virtual and high-throughput screenings

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The N-terminal octapeptide acts as a dimerization inhibitor of SARS coronavirus 3C-like proteinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis of mercury- and zinc-conjugated complexes as SARS-CoV 3C-like protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A quick diversity-oriented amide-forming reaction to optimize P-subsite residues of HIV protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Virtual screening and its integration with modern drug design technologies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibiting the assembly of protein-protein interfaces.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The discovery of odanacatib (MK-0822), a selective inhibitor of cathepsin K.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A structural view of the inactivation of the SARS coronavirus main proteinase by benzotriazole esters

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis, Purification, and Substrate Specificity of Severe Acute Respiratory Syndrome Coronavirus 3C-like Proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-activity relationship studies of a bisbenzimidazole-based, Zn(2+)-dependent inhibitor of HCV NS3 serine protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design and synthesis of highly potent SARS-CoV 3CL protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 reproduction is inhibited by peptides derived frm the N- and C-termini of HIV-1 protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WHO declares Beijing to be free of SARS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A major outbreak of severe acute respiratory syndrome in Hong Kong

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe Acute Respiratory Syndrome: Clinical Outcome and Prognostic Correlates

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid diversity-oriented synthesis in microtiter plates for in situ screening: discovery of potent and selective alpha-fucosidase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design, synthesis, and evaluation of peptide-mimetic SARS 3CL protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apixaban: a novel oral inhibitor of factor Xa.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WHO says SARS outbreak is over, but fight should go on.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific Plant Terpenoids and Lignoids Possess Potent Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A new lead for nonpeptidic active-site-directed inhibitors of the severe acute respiratory syndrome coronavirus main protease discovered by a combination of screening and docking methods

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding interaction of quercetin-3-beta-galactoside and its synthetic derivatives with SARS-CoV 3CL(pro): structure-activity relationship studies reveal salient pharmacophore features

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structures reveal an induced-fit binding of a substrate-like Aza-peptide epoxide to SARS coronavirus main peptidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenic murine coronaviruses II. Characterization of virus-specific proteins of murine coronaviruses JHMV and A59V

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening of drugs by FRET analysis identifies inhibitors of SARS-CoV 3CL protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biosynthesis, purification, and characterization of the human coronavirus 229E 3C-like proteinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissociative inhibition of dimeric enzymes. Kinetic characterization of the inhibition of HIV-1 protease by its COOH-terminal tetrapeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel coronavirus in patients with severe acute respiratory syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and antiviral activity of 6-chloropurine arabinoside and its 2'-deoxy-2'-fluoro derivative

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the norovirus 3C-like protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Individual and common inhibitors of coronavirus and picornavirus main proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery, synthesis, and structure-based optimization of a series of N-(tert-butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus [...]

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and characterization of 3-arylquinazolinone and 3-arylquinazolinethione derivatives as selective estrogen receptor beta modulators

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dissection study on the severe acute respiratory syndrome 3C-like protease reveals the critical role of the extra domain in dimerization of the enzyme: defining the extra domain as a new target for design of highly specific protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of a novel family of SARS-CoV protease inhibitors by virtual screening and 3D-QSAR studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of novel inhibitors of the SARS coronavirus main protease 3CLpro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and evaluation of trifluoromethyl ketones as inhibitors of SARS-CoV 3CL protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

VX-166: a novel potent small molecule caspase inhibitor as a potential therapy for sepsis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based drug design and structural biology study of novel nonpeptide inhibitors of severe acute respiratory syndrome coronavirus main protease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular docking identifies the binding of 3-chloropyridine moieties specifically to the S1 pocket of SARS-CoV Mpro

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biflavonoids from Torreya nucifera displaying SARS-CoV 3CL(pro) inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of picomolar slow tight-binding inhibitors of alpha-fucosidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anticoagulant properties, clinical efficacy and safety of efegatran, a direct thrombin inhibitor, in patients with unstable angina

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the dimerization interface for irreversible inhibition of HIV-1 protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crystal structure of cruzain: a therapeutic target for Chagas' disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The complete sequence (22 kilobases) of murine coronavirus gene 1 encoding the putative proteases and RNA polymerase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of potent anilide inhibitors against the severe acute respiratory syndrome 3CL protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New non-peptidic Inhibitors of Papain Derived from Etacrynic Acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of keto-glutamine analogues as inhibitors of hepatitis A virus 3C proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of dipeptidyl glutaminyl fluoromethyl ketones as potent severe acute respiratory syndrome coronovirus (SARS-CoV) inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanistic view of enzyme inhibition and peptide hydrolysis in the active site of the SARS-CoV 3C-like peptidase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fluoro ketone inhibitors of hydrolytic enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of potent selective zinc-mediated serine protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CL(pro) inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progress in Anti-SARS Coronavirus Chemistry, Biology and Chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Recent development and application of virtual screening in drug discovery: an overview

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of N-(benzo[1,2,3]triazol-1-yl)-N-(benzyl)acetamido)phenyl) carboxamides as severe acute respiratory syndrome coronavirus (SARS-CoV) 3CLpro inhibitors: Identification of ML300 and noncovalent nanomolar inhibitors with an induced-fit binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic alpha,beta-unsaturated esters

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Papain-like protease 2 (PLP2) from severe acute respiratory syndrome coronavirus (SARS-CoV): expression, purification, characterization, and inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifying inhibitors of the SARS coronavirus proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An efficient method for the synthesis of peptide aldehyde libraries employed in the discovery of reversible SARS coronavirus main protease (SARS-CoV Mpro) inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

X-ray crystallographic investigation of substrate binding to carboxypeptidase A at subzero temperature

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN : II. PATHOLOGY

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biological Properties of Avian Coronavirus RNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: structure-activity relationship study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluation of metal-conjugated compounds as inhibitors of 3CL protease of SARS-CoV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a novel coronavirus associated with severe acute respiratory syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and evaluation of keto-glutamine analogues as potent inhibitors of severe acute respiratory syndrome 3CLpro

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ligand efficiency: a useful metric for lead selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advances in the development of thrombin inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovering severe acute respiratory syndrome coronavirus 3CL protease inhibitors: virtual screening, surface plasmon resonance, and fluorescence resonance energy transfer assays

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and biological evaluation of phosphonopyrimidine and phosphonopurine ribonucleosides

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The inhibition of human immunodeficiency virus proteases by 'interface peptides'.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and evaluation of inhibitors for severe acute respiratory syndrome 3C-like protease based on phthalhydrazide ketones or heteroaromatic esters

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of the maturation process of SARS-CoV 3CL protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WHO investigates China's fall in SARS cases

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the crystal structures and intersubunit interactions of human immunodeficiency and Rous sarcoma virus proteases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against SARS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dirofilaria immitis: effect of fluoromethyl ketone cysteine protease inhibitors on the third- to fourth-stage molt

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Severe acute respiratory syndrome-related coronavirus is inhibited by interferon- alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural variations in keto-glutamines for improved inhibition against hepatitis A virus 3C proteinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based virtual screening against SARS-3CL(pro) to identify novel non-peptidic hits

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of potent dipeptide-type SARS-CoV 3CL protease inhibitors with novel P3 scaffolds: design, synthesis, biological evaluation, and docking studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Genome sequence of the SARS-associated coronavirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis, docking studies, and evaluation of pyrimidines as inhibitors of SARS-CoV 3CL protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ribavirin in the treatment of SARS: A new trick for an old drug?

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coronavirus as a possible cause of severe acute respiratory syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The pharmacology of the insulinomimetic effect of zinc complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dimerization inhibitors of HIV-1 protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current status of severe acute respiratory syndrome in China

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal structures of the main peptidase from the SARS coronavirus inhibited by a substrate-like aza-peptide epoxide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26878082

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACS.JMEDCHEM.5B01461

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878082%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

release_mqm7ucwionelzevi2fqxlrbcg4

1 reference

https://api.fatcat.wiki/v0/release/mqm7ucwionelzevi2fqxlrbcg4

24 November 2022

based on heuristic

mapped directly with Wikidata item

0 references

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26878082%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

ResearchGate publication ID

0 references

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