(Q52664543)

English

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization.

scientific article published on 9 March 2018

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29522317%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

2-Mercapto-Quinazolinones as Inhibitors of Type II NADH Dehydrogenase and Mycobacterium tuberculosis: Structure-Activity Relationships, Mechanism of Action and Absorption, Distribution, Metabolism, and Excretion Characterization (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:29522317%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Mycobacterium tuberculosis

1 reference

based on heuristic

inferred from title

Clifton E Barry

29

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19 March 2020

30

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19 March 2020

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19 March 2020

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19 March 2020

Valerie Mizrahi

12

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19 March 2020

Dirk A. Lamprecht

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19 March 2020

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19 March 2020

Helena I M Boshoff

31

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19 March 2020

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Kyu Y Rhee

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19 March 2020

Thomas R Ioerger

25

object named as

Thomas R Ioerger

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19 March 2020

Maria Osuna-Cabello

19

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Maria Osuna-Cabello

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19 March 2020

16

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Jennifer Riley

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19 March 2020

author name string

Dinakaran Murugesan

1

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19 March 2020

Peter C Ray

2

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19 March 2020

Tracy Bayliss

3

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19 March 2020

Gareth A Prosser

4

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19 March 2020

Justin R Harrison

5

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19 March 2020

Kirsteen Green

6

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19 March 2020

Candice Soares de Melo

7

1 reference

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19 March 2020

Tzu-Shean Feng

8

1 reference

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19 March 2020

Leslie J Street

9

1 reference

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19 March 2020

Ola Epemolu

13

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19 March 2020

Paul Scullion

14

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19 March 2020

Lucy Ellis

15

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19 March 2020

Yoko Shishikura

17

1 reference

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19 March 2020

Liam Ferguson

18

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19 March 2020

Kevin D Read

20

1 reference

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19 March 2020

Simon R Green

21

1 reference

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19 March 2020

Peter M Finin

23

1 reference

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19 March 2020

Jim Sacchettini

26

1 reference

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19 March 2020

Kriti Arora

28

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19 March 2020

publication date

26 March 2018

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19 March 2020

ACS Infectious Diseases

1 reference

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19 March 2020

4

1 reference

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19 March 2020

954-969

1 reference

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19 March 2020

6

1 reference

Europe PubMed Central

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19 March 2020

Susceptibility of Mycobacterium tuberculosis cytochrome bd oxidase mutants to compounds targeting the terminal respiratory oxidase, cytochrome c.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5996347

3 July 2018

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5996347

3 July 2018

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5996347

3 July 2018

Essential but not vulnerable: indazole sulfonamides targeting inosine monophosphate dehydrogenase as potential leads against Mycobacterium tuberculosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5996347

3 July 2018

Inhibiting Mycobacterium tuberculosis within and without

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5996347

3 July 2018

Bioluminescent Reporters for Rapid Mechanism of Action Assessment in Tuberculosis Drug Discovery

1 reference

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3 July 2018

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

1 reference

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3 July 2018

Drug Resistance Mechanisms in Mycobacterium tuberculosis

1 reference

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3 July 2018

Molecular Property Design: Does Everyone Get It?

1 reference

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3 July 2018

Predicting toxicities of reactive metabolite-positive drug candidates

1 reference

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3 July 2018

Respiratory flexibility in response to inhibition of cytochrome C oxidase in Mycobacterium tuberculosis

1 reference

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3 July 2018

Quinolinyl Pyrimidines: Potent Inhibitors of NDH-2 as a Novel Class of Anti-TB Agents

1 reference

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3 July 2018

New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects

1 reference

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3 July 2018

Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis

1 reference

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3 July 2018

Mycobacterium tuberculosis type II NADH-menaquinone oxidoreductase catalyzes electron transfer through a two-site ping-pong mechanism and has two quinone-binding sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5996347

3 July 2018

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation

1 reference

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3 July 2018

Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing

1 reference

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3 July 2018

Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis

1 reference

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3 July 2018

Cost-effectiveness of novel first-line treatment regimens for tuberculosis.

1 reference

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3 July 2018

High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism

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3 July 2018

Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States

1 reference

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3 July 2018

Reduction of clofazimine by mycobacterial type 2 NADH:quinone oxidoreductase: a pathway for the generation of bactericidal levels of reactive oxygen species

1 reference

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3 July 2018

New drugs and new regimens for the treatment of tuberculosis: review of the drug development pipeline and implications for national programmes

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3 July 2018

Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in iran.

1 reference

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3 July 2018

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

1 reference

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3 July 2018

125 years after Robert Koch's discovery of the tubercle bacillus: the new XDR-TB threat. Is "science" enough to tackle the epidemic?

1 reference

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3 July 2018

Inhibitors of type II NADH:menaquinone oxidoreductase represent a class of antitubercular drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5996347

3 July 2018

DnaE2 polymerase contributes to in vivo survival and the emergence of drug resistance in Mycobacterium tuberculosis

1 reference

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3 July 2018

Genes required for mycobacterial growth defined by high density mutagenesis

1 reference

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3 July 2018

Characterization of a Mycobacterium tuberculosis H37Rv transposon library reveals insertions in 351 ORFs and mutants with altered virulence

1 reference

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3 July 2018

Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition.

1 reference

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Small molecules targeting Mycobacterium tuberculosis type II NADH dehydrogenase with antimycobacterial activity.

1 reference

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Fluorine in medicinal chemistry

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based on heuristic

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Identifiers

10.1021/ACSINFECDIS.7B00275

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Europe PubMed Central

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19 March 2020

1 reference

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19 March 2020

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19 March 2020

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