(Q52716781)

27 June 2018

title

Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. (English)

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27 June 2018

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John D Belcher

1

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author name string

Chunsheng Chen

2

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27 June 2018

Julia Nguyen

3

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27 June 2018

Fuad Abdulla

4

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27 June 2018

Ping Zhang

5

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27 June 2018

Hao Nguyen

6

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27 June 2018

Phong Nguyen

7

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27 June 2018

Trevor Killeen

8

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27 June 2018

Sylvia M Miescher

9

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27 June 2018

Nathan Brinkman

10

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27 June 2018

Karl A Nath

11

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27 June 2018

Clifford J Steer

12

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27 June 2018

Gregory M Vercellotti

13

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27 June 2018

language of work or name

English

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publication date

25 April 2018

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27 June 2018

published in

PLOS One

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27 June 2018

volume

13

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27 June 2018

issue

4

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27 June 2018

page(s)

e0196455

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27 June 2018

Creative Commons Attribution 4.0 International

copyright license

start time

25 April 2018

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5919001/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

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Sustained treatment of sickle cell mice with haptoglobin increases HO-1 and H-ferritin expression and decreases iron deposition in the kidney without improvement in kidney function

30 June 2018

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Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease

30 June 2018

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Oxidized Ferric and Ferryl Forms of Hemoglobin Trigger Mitochondrial Dysfunction and Injury in Alveolar Type I Cells

30 June 2018

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30 June 2018

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30 June 2018

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Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease

30 June 2018

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30 June 2018

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30 June 2018

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30 June 2018

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30 June 2018

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30 June 2018

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Increased striatal injury and behavioral deficits after intracerebral hemorrhage in hemopexin knockout mice

30 June 2018

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30 June 2018

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30 June 2018

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30 June 2018

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30 June 2018

1 reference

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30 June 2018

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Heme-hemopexin complex attenuates neuronal cell death and stroke damage

30 June 2018

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Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload

30 June 2018

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30 June 2018

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30 June 2018

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30 June 2018

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Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Plasma protein haptoglobin modulates renal iron loading

30 June 2018

1 reference

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CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response.

30 June 2018

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30 June 2018

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Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

30 June 2018

1 reference

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Enhanced splenomegaly and severe liver inflammation in haptoglobin/hemopexin double-null mice after acute hemolysis

30 June 2018

1 reference

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Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm

30 June 2018

1 reference

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Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Exchange of heme among hemoglobins and between hemoglobin and albumin

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Transfer of heme from ferrihemoglobin and ferrihemoglobin isolated chains to hemopexin.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Receptor-mediated transport of heme by hemopexin regulates gene expression in mammalian cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Ferritin: a cytoprotective antioxidant strategem of endothelium

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Expression of haptoglobin receptors in human hepatoma cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Case series supporting heme detoxification via therapeutic plasma exchange in acute multiorgan failure syndrome resistant to red blood cell exchange in sickle cell disease

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Hemopexin therapy improves cardiovascular function by preventing heme-induced endothelial toxicity in mouse models of hemolytic diseases

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC).

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Characterization of heme as activator of Toll-like receptor 4.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Identification of the receptor scavenging hemopexin-heme complexes.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Microvascular blood flow and stasis in transgenic sickle mice: utility of a dorsal skin fold chamber for intravital microscopy.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface.

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases

13 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5919001

Oxidative reactions of hemoglobin

13 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29694434

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heme induces the expression of adhesion molecules ICAM-1, VCAM-1, and E selectin in vascular endothelial cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29694434

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0196455

1 reference

27 June 2018

PMC publication ID

5919001

1 reference

27 June 2018

PubMed publication ID

29694434

1 reference

27 June 2018