(Q52926349)

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The toxicity of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity.

scientific article published on 6 August 2015

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Europe PubMed Central

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21 February 2020

The toxicity of the Aggregatibacter actinomycetemcomitans cytolethal distending toxin correlates with its phosphatidylinositol-3,4,5-triphosphate phosphatase activity (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26247396%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Aggregatibacter actinomycetemcomitans

object named as

Aggregatibacter actinomycetemcomitans

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based on heuristic

inferred from title

6

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21 February 2020

Kathleen Boesze-Battaglia

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Kathleen Boesze-Battaglia

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Bruce J Shenker

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21 February 2020

Monika Damek Scuron

3

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21 February 2020

Lisa P Walker

4

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21 February 2020

Ali Zekavat

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21 February 2020

publication date

2 September 2015

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21 February 2020

Cellular Microbiology

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21 February 2020

18

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21 February 2020

2

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21 February 2020

223-243

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21 February 2020

Cholesterol-rich membrane microdomains mediate cell cycle arrest induced by Actinobacillus actinomycetemcomitans cytolethal-distending toxin

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Cytolethal distending toxin-induced cell cycle arrest of lymphocytes is dependent upon recognition and binding to cholesterol

1 reference

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21 January 2018

Regulation of T-cell responses by PTEN

1 reference

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21 January 2018

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

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21 January 2018

Haploid genetic screens in human cells identify host factors used by pathogens

1 reference

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21 January 2018

The cytolethal distending toxins induce DNA damage and cell cycle arrest.

1 reference

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21 January 2018

The Haemophilus ducreyi cytolethal distending toxin induces cell cycle arrest and apoptosis via the DNA damage checkpoint pathways.

1 reference

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21 January 2018

Investigation of the interaction among the components of the cytolethal distending toxin of Haemophilus ducreyi.

1 reference

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21 January 2018

Functionally unrelated signalling proteins contain a fold similar to Mg2+-dependent endonucleases

1 reference

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21 January 2018

The family of inositol and phosphatidylinositol polyphosphate 5-phosphatases

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Escherichia coli CdtB mediates cytolethal distending toxin cell cycle arrest

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

DNase I homologous residues in CdtB are critical for cytolethal distending toxin-mediated cell cycle arrest

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Cytolethal distending toxins and activation of DNA damage-dependent checkpoint responses

1 reference

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21 January 2018

The Haemophilus ducreyi cytolethal distending toxin induces DNA double-strand breaks and promotes ATM-dependent activation of RhoA.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Phosphatidylinositol biosynthesis: biochemistry and regulation

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Bacterial genotoxin triggers FEN1-dependent RhoA activation, cytoskeleton remodeling and cell survival.

1 reference

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21 January 2018

A bacterial cytotoxin identifies the RhoA exchange factor Net1 as a key effector in the response to DNA damage

1 reference

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21 January 2018

Campylobacter jejuni cytolethal distending toxin promotes DNA repair responses in normal human cells

1 reference

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21 January 2018

Cytolethal distending toxin demonstrates genotoxic activity in a yeast model

1 reference

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21 January 2018

Lipid signaling in T-cell development and function

1 reference

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21 January 2018

In vitro and in vivo anti-cancer activity of formononetin on human cervical cancer cell line HeLa

1 reference

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21 January 2018

Thioridazine induces apoptosis by targeting the PI3K/Akt/mTOR pathway in cervical and endometrial cancer cells

1 reference

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21 January 2018

Phosphoinositides: regulators of membrane traffic and protein function

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Lipid phosphatases in the immune system

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

A bacterial toxin that controls cell cycle progression as a deoxyribonuclease I-like protein

1 reference

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21 January 2018

mTOR pathway as a target in tissue hypertrophy.

1 reference

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21 January 2018

The Haemophilus ducreyi cytolethal distending toxin activates sensors of DNA damage and repair complexes in proliferating and non-proliferating cells

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Lipid second messengers

1 reference

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21 January 2018

Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy

1 reference

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21 January 2018

The role of phosphatases in inositol signaling reactions

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Functional studies of the recombinant subunits of a cytolethal distending holotoxin

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Regulation of the immune response by SHIP.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Cytolethal distending toxin from Aggregatibacter actinomycetemcomitans induces DNA damage, S/G2 cell cycle arrest, and caspase- independent death in a Saccharomyces cerevisiae model

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Regulation of second messengers by the inositol polyphosphate 5-phosphatases

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Induction of T-cell apoptosis by Actinobacillus actinomycetemcomitans mutants with deletion of ltxA and cdtABC genes: possible activity of GroEL-like molecule.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Assembly and function of a bacterial genotoxin

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Caspase-2 and caspase-7 are involved in cytolethal distending toxin-induced apoptosis in Jurkat and MOLT-4 T-cell lines.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Distribution of the cytolethal distending toxin A gene (cdtA) among species of Shigella and Vibrio, and cloning and sequencing of the cdt gene from Shigella dysenteriae.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces apoptosis in nonproliferating macrophages by a phosphatase-independent mechanism

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Glycogen synthase kinase 3: more than a namesake

1 reference

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21 January 2018

The physiology of phosphoinositides

1 reference

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21 January 2018

PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression

1 reference

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21 January 2018

The bacterial cytolethal distending toxin (CDT) triggers a G2 cell cycle checkpoint in mammalian cells without preliminary induction of DNA strand breaks.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation

1 reference

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21 January 2018

PIP3 regulation as promising targeted therapy of mast-cell-mediated diseases

1 reference

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21 January 2018

Actinobacillus actinomycetemcomitans cytolethal distending toxin (Cdt): evidence that the holotoxin is composed of three subunits: CdtA, CdtB, and CdtC.

1 reference

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21 January 2018

Exposure of lymphocytes to high doses of Actinobacillus actinomycetemcomitans cytolethal distending toxin induces rapid onset of apoptosis-mediated DNA fragmentation

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

A novel mode of action for a microbial-derived immunotoxin: the cytolethal distending toxin subunit B exhibits phosphatidylinositol 3,4,5-triphosphate phosphatase activity.

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Expression of the cytolethal distending toxin (Cdt) operon in Actinobacillus actinomycetemcomitans: evidence that the CdtB protein is responsible for G2 arrest of the cell cycle in human T cells

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Induction of apoptosis in human T cells by Actinobacillus actinomycetemcomitans cytolethal distending toxin is a consequence of G2 arrest of the cell cycle

1 reference

https://api.crossref.org/works/10.1111%2FCMI.12497

21 January 2018

Inhibition of mast cell degranulation by a chimeric toxin containing a novel phosphatidylinositol-3,4,5-triphosphate phosphatase

1 reference

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21 January 2018

Blockade of the PI-3K signalling pathway by the Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces macrophages to synthesize and secrete pro-inflammatory cytokines

1 reference

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21 January 2018

Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae

1 reference

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21 January 2018

Cytolethal distending toxins

1 reference

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21 January 2018

Inositol lipid 5-phosphatases--traffic signals and signal traffic.

1 reference

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21 January 2018

Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans

1 reference

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21 January 2018

PI3K pathway alterations in cancer: variations on a theme

1 reference

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21 January 2018

Identifiers

10.1111/CMI.12497

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26247396%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26247396%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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