(Q52994249)

10 May 2018

title

Melatonin stimulates the nonamyloidogenic processing of βAPP through the positive transcriptional regulation of ADAM10 and ADAM17. (English)

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8

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author name string

Mayuri Shukla

1

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Htut Htut Htoo

2

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Phitchayapak Wintachai

3

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Jean-Francois Hernandez

4

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Claire Dubois

5

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Rolf Postina

6

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Huaxi Xu

7

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Duncan R Smith

9

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Piyarat Govitrapong

10

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Bruno Vincent

11

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publication date

27 December 2014

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Journal of Pineal Research

published in

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volume

58

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issue

2

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page(s)

151-165

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Role of the melatonin system in the control of sleep: therapeutic implications

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Melatonin in Alzheimer's disease

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Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease

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Protective effect of melatonin on beta-amyloid-induced apoptosis in rat astroglioma C6 cells and its mechanism

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Melatonin attenuates amyloid beta25-35-induced apoptosis in mouse microglial BV2 cells

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Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

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Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease.

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Chronic melatonin therapy fails to alter amyloid burden or oxidative damage in old Tg2576 mice: implications for clinical trials

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Melatonin affects the metabolism of the beta-amyloid precursor protein in different cell types

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M1 receptors play a central role in modulating AD-like pathology in transgenic mice

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In vitro stimulation of protein kinase C by melatonin

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Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

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A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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Design and characterization of a novel cellular prion-derived quenched fluorimetric substrate of alpha-secretase

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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Effect of melatonin and melatonylvalpromide on beta-amyloid and neurofilaments in N2a cells

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Melatonin protects SHSY5Y neuroblastoma cells from cobalt-induced oxidative stress, neurotoxicity and increased beta-amyloid secretion

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Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation

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Melatonin reduces interleukin secretion in amyloid-beta stressed mouse brain slices

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Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex

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Expression of membrane and nuclear melatonin receptors in mouse peripheral organs.

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Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide

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Melatonin modulates the expression of VEGF and HIF-1 alpha induced by CoCl2 in cultured cancer cells

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Melatonin down-regulates HIF-1 alpha expression through inhibition of protein translation in prostate cancer cells.

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Melatonin suppresses tumor angiogenesis by inhibiting HIF-1alpha stabilization under hypoxia

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Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase

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Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation.

21 January 2018

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p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

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Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques

21 January 2018

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Platelet APP, ADAM 10 and BACE alterations in the early stages of Alzheimer disease

21 January 2018

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Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients

21 January 2018

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Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease.

21 January 2018

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Melatonin: functions and ligands

21 January 2018

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Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

21 January 2018

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The transcriptionally active amyloid precursor protein (APP) intracellular domain is preferentially produced from the 695 isoform of APP in a {beta}-secretase-dependent pathway

21 January 2018

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Disease-modified glycogen synthase kinase-3β intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model.

21 January 2018

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Amyloid-β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

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21 January 2018

Identifiers

DOI

10.1111/JPI.12200

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10 May 2018

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10 May 2018