(Q53143357)

English

Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer.

scientific article published on 25 September 2012

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer. (English)

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

author name string

Xiaolan Qian

1

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Marian E Durkin

2

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Dunrui Wang

3

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Brajendra K Tripathi

4

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Lyra Olson

5

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Xu-Yu Yang

6

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

William C Vass

7

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Nicholas C Popescu

8

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Douglas R Lowy

9

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

language of work or name

0 references

publication date

25 September 2012

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Cancer Research

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

72

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

5900-5911

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

22

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Cell cycle, CDKs and cancer: a changing paradigm

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the p16INK4a tumor suppressor versus other INK4 family members during mouse development and aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The bovine papillomavirus E5 oncogene can cooperate with ras: identification of p21 amino acids critical for transformation by c-rasH but not v-rasH.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho GTPase-activating protein deleted in liver cancer suppresses cell proliferation and invasion in hepatocellular carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Tensin-3 protein, including its SH2 domain, is phosphorylated by Src and contributes to tumorigenesis and metastasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Complete deletion of Apc results in severe polyposis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A role for Rho in Ras transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DLC-1: a Rho GTPase-activating protein and tumour suppressor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of DLC-1 in clear cell renal cell carcinoma: prognostic significance for progression and metastasis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho kinase proteins--pleiotropic modulators of cell survival and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetics and genomics of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrative genomic identification of genes on 8p associated with hepatocellular carcinoma progression and patient survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Helper-independent transformation by unintegrated Harvey sarcoma virus DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cdc42 regulates anchorage-independent growth and is necessary for Ras transformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of Dlc1 isoform 2 in K-Ras2(G12D) induced thymic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Advanced rai stage in patients with chronic lymphocytic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immortalization of human bronchial epithelial cells in the absence of viral oncoproteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/23010077

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-12-2368

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

0 references

1 reference

Europe PubMed Central

11 May 2018

http://europepmc.org/abstract/MED/23010077

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q53143357&oldid=1415231479"