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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
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title
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
(English)
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PubMed
author name string
Vigil D
series ordinal
1
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Cherfils J
series ordinal
2
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PubMed
Rossman KL
series ordinal
3
1 reference
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PubMed
Der CJ
series ordinal
4
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PubMed
language of work or name
English
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publication date
December 2010
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PubMed
published in
Nature Reviews Cancer
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PubMed
volume
10
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PubMed
issue
12
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PubMed
page(s)
842-57
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PubMed
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The centaurin gamma-1 GTPase-like domain functions as an NTPase
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Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS
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RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia
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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
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Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras
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A novel bifunctional phospholipase c that is regulated by Galpha 12 and stimulates the Ras/mitogen-activated protein kinase pathway
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Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
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Asef, a link between the tumor suppressor APC and G-protein signaling
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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia
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Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis
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20 March 2017
Brefeldin A acts to stabilize an abortive ARF-GDP-Sec7 domain protein complex: involvement of specific residues of the Sec7 domain
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The structural basis of the activation of Ras by Sos
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RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs
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The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants
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Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene
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Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene
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vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells
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The genomic landscapes of human breast and colorectal cancers
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The consensus coding sequences of human breast and colorectal cancers
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20 March 2017
The guanine nucleotide-binding switch in three dimensions
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20 March 2017
Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells
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Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N‐terminal cell cycle regulator‐related domains
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20 March 2017
Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon
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20 March 2017
Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity
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20 March 2017
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
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20 March 2017
Activated PAK4 regulates cell adhesion and anchorage-independent growth
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20 March 2017
Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms
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20 March 2017
Rac activation and inactivation control plasticity of tumor cell movement
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20 March 2017
DLC1: a significant GAP in the cancer genome
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20 March 2017
DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma
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20 March 2017
Rho GTPases: functions and association with cancer
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20 March 2017
GEFs and GAPs: critical elements in the control of small G proteins
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20 March 2017
PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion
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PubMed Central
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124093
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20 March 2017
Germline gain-of-function mutations in SOS1 cause Noonan syndrome
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PubMed Central
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PubMed Central
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20 March 2017
Identification of small-molecule inhibitors of RGS4 using a high-throughput flow cytometry protein interaction assay
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20 March 2017
Activated tyrosine kinase Ack1 promotes prostate tumorigenesis: role of Ack1 in polyubiquitination of tumor suppressor Wwox
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PubMed Central
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PubMed Central
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20 March 2017
CZH proteins: a new family of Rho-GEFs
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PubMed Central
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PubMed Central
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20 March 2017
Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion
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PubMed Central
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PubMed Central
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20 March 2017
Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis
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PubMed Central
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20 March 2017
Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis
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20 March 2017
PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion
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20 March 2017
Phospholipase C(epsilon): a novel Ras effector
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20 March 2017
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13
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PubMed Central
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20 March 2017
Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP
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PubMed Central
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20 March 2017
Oncogene ect2 is related to regulators of small GTP-binding proteins
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PubMed Central
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20 March 2017
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
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7 April 2017
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
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7 April 2017
Ras oncogenes: split personalities
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7 April 2017
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
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7 April 2017
ARF proteins: roles in membrane traffic and beyond
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7 April 2017
The Ras superfamily at a glance
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7 April 2017
Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
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7 April 2017
Differing modes of tumour cell invasion have distinct requirements for Rho/ROCK signalling and extracellular proteolysis
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7 April 2017
Structural basis for activation of ARF GTPase: mechanisms of guanine nucleotide exchange and GTP-myristoyl switching
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7 April 2017
Brefeldin A inhibits Golgi membrane-catalysed exchange of guanine nucleotide onto ARF protein
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7 April 2017
Ras history: The saga continues
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29 September 2017
New strategies for treatment of KRAS mutant metastatic colorectal cancer
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29 September 2017
Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA
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29 September 2017
Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis
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29 September 2017
A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway
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29 September 2017
Genetics and molecular biology of tuberous sclerosis complex
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29 September 2017
Host deficiency in Vav2/3 guanine nucleotide exchange factors impairs tumor growth, survival, and angiogenesis in vivo
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29 September 2017
The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis
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29 September 2017
Mechanisms in the pathogenesis of malignant tumours in neurofibromatosis type 1.
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29 September 2017
Aptamer-derived peptides as potent inhibitors of the oncogenic RhoGEF Tgat
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29 September 2017
Rho GTPase function in tumorigenesis
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29 September 2017
Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis
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29 September 2017
Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment
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29 September 2017
Novel agents on the horizon for cancer therapy
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29 September 2017
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo
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29 September 2017
High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay
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29 September 2017
Golgicide A reveals essential roles for GBF1 in Golgi assembly and function
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29 September 2017
GGAP2/PIKE-a directly activates both the Akt and nuclear factor-kappaB pathways and promotes prostate cancer progression.
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29 September 2017
Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion
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29 September 2017
Involvement of epithelial cell transforming sequence-2 oncoantigen in lung and esophageal cancer progression.
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29 September 2017
DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling
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29 September 2017
Contribution of AZAP-Type Arf GAPs to cancer cell migration and invasion
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29 September 2017
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer
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29 September 2017
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma.
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29 September 2017
ADP-ribosylation factor 1 controls the activation of the phosphatidylinositol 3-kinase pathway to regulate epidermal growth factor-dependent growth and migration of breast cancer cells
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29 September 2017
Correlation between ECT2 gene expression and methylation change of ECT2 promoter region in pancreatic cancer
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29 September 2017
Consensus nomenclature for the human ArfGAP domain-containing proteins
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29 September 2017
Wealth of opportunity - the C1 domain as a target for drug development
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29 September 2017
Many faces of Ras activation
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29 September 2017
Role of the C-terminal SH3 domain and N-terminal tyrosine phosphorylation in regulation of Tim and related Dbl-family proteins
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29 September 2017
ASAP1, a gene at 8q24, is associated with prostate cancer metastasis
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29 September 2017
Rho GTPases in cancer cell biology
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29 September 2017
Inhibitors of chronically active ras: potential for treatment of human malignancies.
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29 September 2017
RalGDS couples growth factor signaling to Akt activation
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29 September 2017
Applications for ROCK kinase inhibition
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29 September 2017
Ral GTPases and cancer: linchpin support of the tumorigenic platform
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29 September 2017
Fbx8 makes Arf6 refractory to function via ubiquitination.
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29 September 2017
GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion.
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29 September 2017
SOS1 mutations are rare in human malignancies: implications for Noonan Syndrome patients
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29 September 2017
The RhoGEF domain of p210 Bcr-Abl activates RhoA and is required for transformation
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29 September 2017
Structure-based discovery of an inhibitor of Arf activation by Sec7 domains through targeting of protein-protein complexes
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29 September 2017
Lack of extracellular signal-regulated kinase mitogen-activated protein kinase signaling shows a new type of melanoma
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29 September 2017
Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.
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29 September 2017
Current knowledge of the large RhoGAP family of proteins
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29 September 2017
Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.
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29 September 2017
Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistance
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29 September 2017
Expression level of ECT2 proto-oncogene correlates with prognosis in glioma patients
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29 September 2017
ArfGAP family proteins in cell adhesion, migration and tumor invasion.
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29 September 2017
A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion
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29 September 2017
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis
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29 September 2017
Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay
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29 September 2017
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.
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29 September 2017
EFA6A enhances glioma cell invasion through ADP ribosylation factor 6/extracellular signal-regulated kinase signaling.
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29 September 2017
Metastatic properties and genomic amplification of the tyrosine kinase gene ACK1
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29 September 2017
RalA and RalB: antagonistic relatives in cancer cell migration
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29 September 2017
Signaling interplay in Ras superfamily function
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29 September 2017
DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma
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29 September 2017
Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.
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29 September 2017
RalGDS is required for tumor formation in a model of skin carcinogenesis.
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29 September 2017
Interfacial inhibition of macromolecular interactions: nature's paradigm for drug discovery
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29 September 2017
Human RAS superfamily proteins and related GTPases
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29 September 2017
An alternative transcript derived from the trio locus encodes a guanosine nucleotide exchange factor with mouse cell-transforming potential
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29 September 2017
The Rheb family of GTP-binding proteins
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29 September 2017
Requirement for Arf6 in breast cancer invasive activities
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29 September 2017
Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas.
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29 September 2017
Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma
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29 September 2017
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism
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29 September 2017
Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA.
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29 September 2017
Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers
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29 September 2017
Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain
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29 September 2017
Regulation of RasGRP via a phorbol ester-responsive C1 domain.
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29 September 2017
Expression cloning of oncogenes by retroviral transfer of cDNA libraries
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29 September 2017
Purification of ras GTPase activating protein from bovine brain
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29 September 2017
Virtual screening approach for the identification of new Rac1 inhibitors
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2 June 2018
Crucial role of phospholipase C epsilon in skin inflammation induced by tumor-promoting phorbol ester
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2 June 2018
Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation
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2 June 2018
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.
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2 June 2018
Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines
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2 June 2018
Transformation mediated by RhoA requires activity of ROCK kinases
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2 June 2018
Dbl family proteins
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2 June 2018
Prognostic value of 64-slice cardiac computed tomography severity of coronary artery disease, coronary atherosclerosis, and left ventricular ejection fraction
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27 November 2018
Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi.
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27 November 2018
Progression of breast tumors is accompanied by a decrease in expression of the Rho guanine exchange factor Tiam1.
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27 November 2018
Activation of leukemia-associated RhoGEF by Galpha13 with significant conformational rearrangements in the interface
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27 November 2018
Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice
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27 November 2018
DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis.
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27 November 2018
Auto-inhibition of the Dbl Family Protein Tim by an N-terminal Helical Motif
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27 November 2018
Deleted in liver cancer 3 (DLC-3), a novel Rho GTPase-activating protein, is downregulated in cancer and inhibits tumor cell growth.
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27 November 2018
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome.
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27 November 2018
The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3124093
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27 November 2018
Characterisation of the metal-ion-GDP complex at the active sites of transforming and nontransforming p21 proteins by observation of the 17O-Mn superhyperfine coupling and by kinetic methods
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31 March 2020
Neurofibromatosis
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Crossref
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31 March 2020
A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer
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Crossref
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31 March 2020
Structural Basis for Activation of ARF GTPase
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31 March 2020
Decumbin, a New Compound from a Species of Penicillium
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31 March 2020
Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
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Crossref
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https://api.crossref.org/works/10.1038%2FNRC2960
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31 March 2020
Dual specificity of the interfacial inhibitor brefeldin a for arf proteins and sec7 domains
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Crossref
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31 March 2020
Identification of the first Rho-GEF inhibitor, TRIPalpha, which targets the RhoA-specific GEF domain of Trio
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31 March 2020
Identifiers
DOI
10.1038/NRC2960
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1863361
Dimensions Publication ID
1017754395
0 references
OpenCitations bibliographic resource ID
1863361
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1863361
PMC publication ID
3124093
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1863361
PubMed publication ID
21102635
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1863361
ResearchGate publication ID
49631171
0 references
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