(Q53155431)

11 May 2018

title

Deficient DNA damage response and cell cycle checkpoints lead to accumulation of point mutations in human embryonic stem cells. (English)

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11 May 2018

human embryonic stem cell

main subject

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3

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11 May 2018

Nevila Hyka-Nouspikel

1

object named as

Nevila Hyka-Nouspikel

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11 May 2018

author name string

Joëlle Desmarais

2

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11 May 2018

Mark Jones

4

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Mark Meuth

5

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Peter W Andrews

6

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Thierry Nouspikel

7

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publication date

1 September 2012

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11 May 2018

published in

Stem Cells

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volume

30

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issue

9

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11 May 2018

page(s)

1901-1910

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11 May 2018

Core transcriptional regulatory circuitry in human embryonic stem cells

cites work

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The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

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Surface antigens of human embryonic stem cells: changes upon differentiation in culture

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Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells

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Stem cell states, fates, and the rules of attraction

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Aneuploidy and early human embryo development

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Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells

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The tumorigenicity of diploid and aneuploid human pluripotent stem cells

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From teratocarcinomas to embryonic stem cells

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Hypoxia causes downregulation of mismatch repair system and genomic instability in stem cells

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Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

21 January 2018

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Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells

21 January 2018

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Molecular mechanisms of mammalian global genome nucleotide excision repair.

21 January 2018

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DNA repair in terminally differentiated cells

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Terminally differentiated human neurons repair transcribed genes but display attenuated global DNA repair and modulation of repair gene expression

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Nucleotide excision repair phenotype of human acute myeloid leukemia cell lines at various stages of differentiation

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Transcription domain-associated repair in human cells

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Nucleotide excision repair and B lymphoma: somatic hypermutation is not the only culprit.

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Impaired nucleotide excision repair upon macrophage differentiation is corrected by E1 ubiquitin-activating enzyme

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Multiple roles of ubiquitination in the control of nucleotide excision repair

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Diversity of the damage recognition step in the global genomic nucleotide excision repair in vitro

21 January 2018

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Role of DNA polymerase eta in the UV mutation spectrum in human cells

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Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

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21 January 2018

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Expression of wild-type p53 is required for efficient global genomic nucleotide excision repair in UV-irradiated human fibroblasts

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Oct-4 controls cell-cycle progression of embryonic stem cells

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Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex

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Translesion synthesis: Y-family polymerases and the polymerase switch

21 January 2018

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Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair

21 January 2018

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The human intra-S checkpoint response to UVC-induced DNA damage

21 January 2018

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Inhibition of the ubiquitin-proteasome system induces stress granule formation.

21 January 2018

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Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate

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Cell cycle features of primate embryonic stem cells.

21 January 2018

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Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.

21 January 2018

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p21-induced cycle arrest in G1 protects cells from apoptosis induced by UV-irradiation or RNA polymerase II blockage

21 January 2018

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Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

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Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

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Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

21 January 2018

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Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks

21 January 2018

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Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants

21 January 2018

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Human embryonic stem cells have enhanced repair of multiple forms of DNA damage

21 January 2018

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DNA damage responses in human induced pluripotent stem cells and embryonic stem cells

21 January 2018

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p53-mediated DNA repair responses to UV radiation: studies of mouse cells lacking p53, p21, and/or gadd45 genes

21 January 2018

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P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation

21 January 2018

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Instability and decay of the primary structure of DNA

21 January 2018

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BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci

21 January 2018

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Sept4/ARTS is required for stem cell apoptosis and tumor suppression

21 January 2018

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Beyond tumorigenesis: cancer stem cells in metastasis

21 January 2018

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Cancer stem cells: controversial or just misunderstood?

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/STEM.1177

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11 May 2018

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11 May 2018