(Q53162347)

12 May 2018

title

Autophagy: a new player in skeletal maintenance? (English)

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12 May 2018

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1

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12 May 2018

author name string

Caroline Whitehouse

series ordinal

2

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12 May 2018

Miep H Helfrich

series ordinal

3

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12 May 2018

publication date

1 July 2012

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12 May 2018

Journal of Bone and Mineral Research

published in

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12 May 2018

volume

27

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12 May 2018

issue

7

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12 May 2018

page(s)

1439-1447

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12 May 2018

New knowledge on critical osteoclast formation and activation pathways from study of rare genetic diseases of osteoclasts: focus on the RANK/RANKL axis.

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Update on Wnt signaling in bone cell biology and bone disease.

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Autophagy in mineralizing tissues: microenvironmental perspectives

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Integration of clearance mechanisms: the proteasome and autophagy

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Molecular machinery of macroautophagy and its deregulation in diseases.

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The role of Atg proteins in autophagosome formation

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Autophagic cell death: Loch Ness monster or endangered species?

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HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy

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Characterization of macroautophagic flux in vivo using a leupeptin-based assay

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Autophagy in mammalian development and differentiation

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Intracellular protein catabolism and its control during nutrient deprivation and supply

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What old means to bone

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Spatial coupling of mTOR and autophagy augments secretory phenotypes.

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Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

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Autophagosomal IkappaB alpha degradation plays a role in the long term control of tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activity.

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Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

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Genetics and aetiology of Pagetic disorders of bone

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A novel mutation (K378X) in the sequestosome 1 gene associated with increased NF-kappaB signaling and Paget's disease of bone with a severe phenotype.

21 January 2018

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Sequestosome 1 mutations in Paget's disease of bone in Australia: prevalence, genotype/phenotype correlation, and a novel non-UBA domain mutation (P364S) associated with increased NF-kappaB signaling without loss of ubiquitin binding.

21 January 2018

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Characterization of a non-UBA domain missense mutation of sequestosome 1 (SQSTM1) in Paget's disease of bone

21 January 2018

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The p62 P392L mutation linked to Paget's disease induces activation of human osteoclasts

21 January 2018

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Dimerisation of the UBA domain of p62 inhibits ubiquitin binding and regulates NF-kappaB signalling

21 January 2018

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The adaptor protein p62/SQSTM1 in osteoclast signaling pathways

21 January 2018

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Functional interaction between sequestosome-1/p62 and autophagy-linked FYVE-containing protein WDFY3 in human osteoclasts

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p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

21 January 2018

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p62 is a key regulator of nutrient sensing in the mTORC1 pathway.

21 January 2018

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A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice.

21 January 2018

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The IKK complex contributes to the induction of autophagy

21 January 2018

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PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation

21 January 2018

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Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein

21 January 2018

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Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system

21 January 2018

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Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.

21 January 2018

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VCP associated inclusion body myopathy and paget disease of bone knock-in mouse model exhibits tissue pathology typical of human disease

21 January 2018

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Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

21 January 2018

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VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

21 January 2018

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Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality

21 January 2018

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Autophagy proteins regulate the secretory component of osteoclastic bone resorption

21 January 2018

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Acidosis, hypoxia and bone

21 January 2018

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Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor signalling and hypoxia

21 January 2018

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Osteoclast precursor differentiation by MCPIP via oxidative stress, endoplasmic reticulum stress, and autophagy

21 January 2018

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Bone growth during rapamycin therapy in young rats

21 January 2018

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Mammalian target of rapamycin signaling is crucial for joint destruction in experimental arthritis and is activated in osteoclasts from patients with rheumatoid arthritis

21 January 2018

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Impact of sirolimus, tacrolimus and mycophenolate mofetil on osteoclastogenesis--implications for post-transplantation bone disease

21 January 2018

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Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPβ - MafB axis.

21 January 2018

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Rapamycin induces growth retardation by disrupting angiogenesis in the growth plate

21 January 2018

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Mammalian target of rapamycin: a signaling kinase for every aspect of cellular life

21 January 2018

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Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks

21 January 2018

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Autophagy in stem cell maintenance and differentiation

21 January 2018

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The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

21 January 2018

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MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1-regulated pathways in mice

21 January 2018

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Bone cell autophagy is regulated by environmental factors

21 January 2018

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Glucocorticoid-induced autophagy in osteocytes

21 January 2018

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21 January 2018

The amazing osteocyte

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Matrix-embedded cells control osteoclast formation

21 January 2018

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Endocrine functions of bone in mineral metabolism regulation.

21 January 2018

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A role for NBR1 in autophagosomal degradation of ubiquitinated substrates

21 January 2018

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Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover

21 January 2018

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Neighbor of Brca1 gene (Nbr1) functions as a negative regulator of postnatal osteoblastic bone formation and p38 MAPK activity

21 January 2018

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Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity

21 January 2018

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NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo

21 January 2018

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Autophagy inhibition promotes defective neosynthesized proteins storage in ALIS, and induces redirection toward proteasome processing and MHCI-restricted presentation.

21 January 2018

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The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway.

21 January 2018

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A novel library screen identifies immunosuppressors that promote osteoblast differentiation

21 January 2018

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Novel UBA domain mutations of SQSTM1 in Paget's disease of bone: genotype phenotype correlation, functional analysis, and structural consequences

21 January 2018

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Selective autophagy in the maintenance of cellular homeostasis in aging organisms

21 January 2018

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Autophagy and aging: the importance of maintaining "clean" cells

21 January 2018

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Cockayne syndrome group B protein prevents the accumulation of damaged mitochondria by promoting mitochondrial autophagy.

21 January 2018

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Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells

21 January 2018

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Aged human bone marrow stromal cells maintaining bone forming capacity in vivo evaluated using an improved method of visualization

21 January 2018

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

21 January 2018

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Nutrient-dependent regulation of autophagy through the target of rapamycin pathway.

21 January 2018

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Pathway-based genome-wide association analysis identified the importance of regulation-of-autophagy pathway for ultradistal radius BMD.

21 January 2018

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p62 at the crossroads of autophagy, apoptosis, and cancer

21 January 2018

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Autophagy in the Pathogenesis of Disease

21 January 2018

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Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-beta levels in a mouse model of Alzheimer's disease

21 January 2018

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Rapamycin treatment augments motor neuron degeneration in SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

21 January 2018

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Bone remodelling at a glance

21 January 2018

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NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JBMR.1668

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12 May 2018

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12 May 2018