(Q53203363)

English

The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.

scientific article published in November 2011

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scholarly article

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Europe PubMed Central

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17 January 2020

The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo (English)

1 reference

Europe PubMed Central

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17 January 2020

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17 January 2020

3

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Isidre Ferrer

1 reference

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17 January 2020

Roger John Davis

4

object named as

Roger J Davis

1 reference

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17 January 2020

author name string

Sonia Mazzitelli

1

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17 January 2020

Ping Xu

2

1 reference

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17 January 2020

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publication date

1 November 2011

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17 January 2020

Journal of Neuroscience

1 reference

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17 January 2020

31

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17 January 2020

16969-16976

1 reference

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17 January 2020

47

1 reference

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17 January 2020

Signal transduction by the JNK group of MAP kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

APP processing is regulated by cytoplasmic phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathways towards and away from Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-Jun NH2-terminal kinase-interacting protein-3 facilitates phosphorylation and controls localization of amyloid-beta precursor protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pin1 promotes production of Alzheimer's amyloid beta from beta-cleaved amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological roles of MKK4 and MKK7: insights from animal models

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of APP695 at Thr668 decreases gamma-cleavage and extracellular Abeta

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amyloid-beta precursor protein is phosphorylated via distinct pathways during differentiation, mitosis, stress, and degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inducible gene inactivation in neurons of the adult mouse forebrain

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The JIP1 scaffold protein regulates axonal development in cortical neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the physiological function and metabolism of AbetaPP by AbetaPP binding proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of c-Jun kinase provides neuroprotection in a model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The genetics of Alzheimer disease: back to the future

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of JNK phosphorylation reverses memory deficit induced by β-amyloid (1-42) associated with decrease of apoptotic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulated cleavage of the Alzheimer amyloid precursor protein: molecular and cellular basis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrogen peroxide mediates amyloid beta protein toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of PS1 deficiency on membrane protein trafficking in neurons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22114267

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4491-11.2011

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22114267%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22114267%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22114267%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

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