(Q53215560)

12 May 2018

title

High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosis. (English)

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Anna M Dahlin

object named as

Anna M Dahlin

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author name string

Martin Isaksson-Mettävainio

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Richard Palmqvist

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Jörgen Rutegård

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Ake Oberg

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Maria L Henriksson

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language of work or name

English

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publication date

9 November 2011

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International Journal of Cancer

published in

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volume

131

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issue

4

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page(s)

779-788

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The role of the CpG island methylator phenotype in colorectal cancer prognosis depends on microsatellite instability screening status

cites work

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Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers.

21 January 2018

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Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases

21 January 2018

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Microsatellite instability in colorectal cancer

21 January 2018

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Allelotype of colorectal carcinomas

21 January 2018

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18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high.

21 January 2018

1 reference

Molecular predictors of survival after adjuvant chemotherapy for colon cancer

21 January 2018

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TGF-beta signalling from cell membrane to nucleus through SMAD proteins

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Signaling of transforming growth factor-beta family members through Smad proteins

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Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses

21 January 2018

1 reference

Frequent loss of SMAD4/DPC4 protein in colorectal cancers

21 January 2018

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The role of SMAD4 in early-onset colorectal cancer

21 January 2018

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Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification

21 January 2018

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Immunohistochemical labeling for dpc4 mirrors genetic status in pancreatic adenocarcinomas : a new marker of DPC4 inactivation

21 January 2018

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Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion

21 January 2018

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Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803.

21 January 2018

1 reference

CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer

21 January 2018

1 reference

One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study

21 January 2018

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The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers

21 January 2018

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BRAF mutation is associated with DNA methylation in serrated polyps and cancers of the colorectum

21 January 2018

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CpG island methylator phenotype-low (CIMP-low) in colorectal cancer: possible associations with male sex and KRAS mutations

21 January 2018

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Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

21 January 2018

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Transforming growth factor beta stimulation of colorectal cancer cell lines: type II receptor bypass and changes in adhesion molecule expression

21 January 2018

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Colorectal cancer: genetics of development and metastasis

21 January 2018

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Somatic frameshift mutations of bone morphogenic protein receptor 2 gene in gastric and colorectal cancers with microsatellite instability

21 January 2018

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Loss of activin receptor type 2 protein expression in microsatellite unstable colon cancers

21 January 2018

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Antimetastatic role of Smad4 signaling in colorectal cancer

21 January 2018

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TGFbeta signaling in growth control, cancer, and heritable disorders

21 January 2018

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Suppression of tumorigenesis and activation of Wnt signaling by bone morphogenetic protein 4 in human cancer cells

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Activin is a potent growth suppressor of epithelial ovarian cancer cells.

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Role of transforming growth factor Beta in human cancer

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SMAD4 as a Prognostic Marker in Colorectal Cancer

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.26473

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12 May 2018

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12 May 2018