(Q53219727)

12 May 2018

review article

1 reference

title

Insights into autotaxin: how to produce and present a lipid mediator. (English)

1 reference

12 May 2018

author

Anastassis Perrakis

series ordinal

2

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12 May 2018

author name string

Wouter H Moolenaar

series ordinal

1

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12 May 2018

publication date

14 September 2011

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12 May 2018

Nature Reviews Molecular Cell Biology

published in

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12 May 2018

volume

12

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12 May 2018

issue

10

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12 May 2018

page(s)

674-679

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12 May 2018

https://scigraph.springernature.com/pub.10.1038/nrm3188

exact match

0 references

cites work

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31 March 2020

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Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production

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Serum-induced membrane depolarization in quiescent fibroblasts: activation of a chloride conductance through the G protein-coupled LPA receptor

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Structural basis of substrate discrimination and integrin binding by autotaxin

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Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

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31 March 2020

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Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex

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Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs

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Biochemical and molecular characterization of a novel choline-specific glycerophosphodiester phosphodiesterase belonging to the nucleotide pyrophosphatase/phosphodiesterase family

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Autotaxin/lysopholipase D and lysophosphatidic acid regulate murine hemostasis and thrombosis

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Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

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1 reference

Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner

31 March 2020

1 reference

Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution

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1 reference

Binding of autotaxin to integrins localizes lysophosphatidic acid production to platelets and mammalian cells

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1 reference

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31 March 2020

1 reference

Serum lysophosphatidic acid is produced through diverse phospholipase pathways

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1 reference

Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources.

31 March 2020

1 reference

Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions

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1 reference

Autotaxin, a secreted lysophospholipase D, is essential for blood vessel formation during development

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1 reference

Autotaxin stabilizes blood vessels and is required for embryonic vasculature by producing lysophosphatidic acid.

31 March 2020

1 reference

Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid

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1 reference

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31 March 2020

1 reference

Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus

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LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing

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1 reference

LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.

31 March 2020

1 reference

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Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases

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1 reference

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31 March 2020

1 reference

In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.

31 March 2020

1 reference

Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells

31 March 2020

1 reference

Cancer cell expression of autotaxin controls bone metastasis formation in mouse through lysophosphatidic acid-dependent activation of osteoclasts

31 March 2020

1 reference

The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer

31 March 2020

1 reference

LPA1 receptor activation promotes renal interstitial fibrosis

31 March 2020

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The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak

31 March 2020

1 reference

Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling

31 March 2020

1 reference

Lipoprotein-Derived Lysophosphatidic Acid Promotes Atherosclerosis by Releasing CXCL1 from the Endothelium

31 March 2020

1 reference

Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure

31 March 2020

1 reference

Lysophosphatidic acid is a potential mediator of cholestatic pruritus

31 March 2020

1 reference

Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma

31 March 2020

1 reference

Fluorogenic phospholipid substrate to detect lysophospholipase D/autotaxin activity

31 March 2020

1 reference

Phosphatase-resistant analogues of lysophosphatidic acid: agonists promote healing, antagonists and autotaxin inhibitors treat cancer

31 March 2020

1 reference

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

31 March 2020

1 reference

A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation

31 March 2020

1 reference

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21915140

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Autotaxin hydrolyzes sphingosylphosphorylcholine to produce the regulator of migration, sphingosine-1-phosphate

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21915140

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification, purification, and partial sequence analysis of autotaxin, a novel motility-stimulating protein

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21915140

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRM3188

1 reference

12 May 2018

1 reference

12 May 2018