(Q53234212)

English

Phase I trial of 7-hydroxystaurosporine and fludararbine phosphate: in vivo evidence of 7-hydroxystaurosporine induced apoptosis in chronic lymphocytic leukemia.

scientific article published on 12 July 2011

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scholarly article

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Europe PubMed Central

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7 February 2020

Phase I trial of 7-hydroxystaurosporine and fludararbine phosphate: in vivo evidence of 7-hydroxystaurosporine induced apoptosis in chronic lymphocytic leukemia (English)

1 reference

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7 February 2020

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phase I clinical trial

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1 reference

based on heuristic

inferred from title

7

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7 February 2020

Maryalice Stetler-Stevenson

2

object named as

Maryalice Stetler-Stevenson

1 reference

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7 February 2020

Wyndham H. Wilson

11

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Wyndham H Wilson

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7 February 2020

Kieron Dunleavy

8

object named as

Kieron Dunleavy

1 reference

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7 February 2020

Seth M Steinberg

10

object named as

Seth M Steinberg

1 reference

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7 February 2020

4

object named as

Therese White

1 reference

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7 February 2020

author name string

Gerald E Marti

1

1 reference

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7 February 2020

Nicole Drbohlav Grant

3

1 reference

Europe PubMed Central

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7 February 2020

William D Figg

5

1 reference

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7 February 2020

Tanyifor Tohnya

6

1 reference

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7 February 2020

John E Janik

9

1 reference

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7 February 2020

publication date

12 July 2011

1 reference

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7 February 2020

Leukemia & Lymphoma

1 reference

Europe PubMed Central

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7 February 2020

52

1 reference

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7 February 2020

2284-2292

1 reference

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7 February 2020

12

1 reference

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7 February 2020

Targeting checkpoint kinase 1 in cancer therapeutics

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine).

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Preclinical and clinical development of cyclin-dependent kinase modulators

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

A high-performance liquid chromatography method using ultraviolet and fluorescence detection for the quantitation of UCN-01, 7-hydroxystaurosporine, from human plasma and saliva

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Physiological modeling of altered pharmacokinetics of a novel anticancer drug, UCN-01 (7-hydroxystaurosporine), caused by slow dissociation of UCN-01 from human alpha1-acid glycoprotein.

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Role of a doxorubicin-containing regimen in relapsed and resistant lymphomas: an 8-year follow-up study of EPOCH.

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

IGF-1 receptor inhibitors in clinical trials--early lessons

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Phase I trial of UCN-01 in combination with topotecan in patients with advanced solid cancers: a Princess Margaret Hospital Phase II Consortium study

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: a study of the Princess Margaret Hospital Phase II consortium

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Phase I trial of the cyclin-dependent kinase inhibitor and protein kinase C inhibitor 7-hydroxystaurosporine in combination with Fluorouracil in patients with advanced solid tumors.

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

The cyclin-dependent kinase inhibitor UCN-01 plus cisplatin in advanced solid tumors: a California cancer consortium phase I pharmacokinetic and molecular correlative trial

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Effects of alpha1-acid glycoprotein on the clinical pharmacokinetics of 7-hydroxystaurosporine

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Acute tumour lysis syndrome after oral fludarabine in a patient with chronic lymphocytic leukaemia

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Tumor lysis syndrome associated with fludarabine treatment in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Tumor lysis syndrome (TLS) following fludarabine therapy for chronic lymphocytic leukemia (CLL): case report and review of the literature

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Variables in the quantification of CD4 in normals and hairy cell leukemia patients

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.3109%2F10428194.2011.589547

21 January 2018

Altered pharmacokinetics of a novel anticancer drug, UCN-01, caused by specific high affinity binding to alpha1-acid glycoprotein in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

UCN-01 enhances the in vitro toxicity of clinical agents in human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II trial of fludarabine phosphate in lymphoma: an effective new agent in low-grade lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I and pharmacokinetic study of short infusions of UCN-01 in patients with refractory solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fludarabine phosphate in the treatment of chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A loading dose/continuous infusion schedule of fludarabine phosphate in chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity of fludarabine in previously treated non-Hodgkin's low-grade lymphoma: results of an Eastern Cooperative Oncology Group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I and pharmacokinetic study of 7-hydroxystaurosporine and carboplatin in advanced solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The treatment of recurrent/refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) with everolimus results in clinical responses and mobilization of CLL cells into the circulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Variables affecting the quantitation of CD22 in neoplastic B cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fludarabine single-agent therapy for relapsed low-grade non-Hodgkin's lymphomas: a phase II study of the German Low-Grade Non-Hodgkin's Lymphoma Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated titration designs for phase I clinical trials in oncology

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor lysis syndrome: an uncommon complication of fludarabine therapy of chronic lymphocytic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/21745173

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.3109/10428194.2011.589547

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21745173%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21745173%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21745173%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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