(Q53236816)

English

Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation.

scientific article published on 4 May 2007

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Characterizing uncertainty and variability in physiologically based pharmacokinetic models: state of the science and needs for research and implementation. (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

pharmacokinetics

1 reference

based on heuristic

inferred from title

Melvin E. Andersen

4

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Frederic Y. Bois

6

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Gunnar Johanson

9

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Christopher Portier

13

object named as

Christopher J Portier

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

author name string

Hugh A Barton

1

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Weihsueh A Chiu

2

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

R Woodrow Setzer

3

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

A John Bailer

5

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Robert S Dewoskin

7

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Sean Hays

8

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Nancy Jones

10

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

George Loizou

11

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Robert C Macphail

12

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Martin Spendiff

14

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Yu-Mei Tan

15

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

publication date

4 May 2007

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Toxicological Sciences

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

99

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

2

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

395-402

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

Applying Simulation Modeling to Problems in Toxicology and Risk Assessment: A Short Perspective

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

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Physiologically based pharmacokinetics and the risk assessment process for methylene chloride.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats.

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

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Development of a physiologically based toxicokinetic model for butadiene and four major metabolites in humans: global sensitivity analysis for experimental design issues.

1 reference

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21 January 2018

Framework for evaluation of physiologically-based pharmacokinetic models for use in safety or risk assessment

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Evaluation of the potential impact of age- and gender-specific pharmacokinetic differences on tissue dosimetry

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Incorporation of pharmacokinetics in noncancer risk assessment: example with chloropentafluorobenzene

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Development and evaluation of a generic physiologically based pharmacokinetic model for children.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Fuzzy simulation of pharmacokinetic models: case study of whole body physiologically based model of diazepam

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Reducing whole body physiologically based pharmacokinetic models using global sensitivity analysis: diazepam case study

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

An Investigation of Uncertainty and Sensitivity Analysis Techniques for Computer Models

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Spreadsheet programming — a new approach in physiologically based modeling of solvent toxicokinetics

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Physiologically based pharmacokinetic modeling of inhalation exposure of humans to dichloromethane during moderate to heavy exercise

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Assessing the reliability of PBPK models using data from methyl chloride-exposed, non-conjugating human subjects.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Antinociceptive effects, metabolism and disposition of ketamine in ponies under target-controlled drug infusion

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Effects of the structure of a toxicokinetic model of butadiene inhalation exposure on computed production of carcinogenic intermediates.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

A physiological pharmacokinetic description of the tissue distribution and enzyme-inducing properties of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat.

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

A human physiological model describing acetone kinetics in blood and breath during various levels of physical exercise

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https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Lumping of whole-body physiologically based pharmacokinetic models

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Using structural information to create physiologically based pharmacokinetic models for all polychlorinated biphenyls

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

The use and abuse of models

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

A physiologically based pharmacokinetic model for inhalation and intravenous administration of naphthalene in rats and mice

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Gas Uptake Inhalation Techniques and the Rates of Metabolism of Chloromethanes, Chloroethanes, and Chloroethylenes in the Rat

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

A Bayesian compartmental model for the evaluation of 1,3-butadiene metabolism

1 reference

https://api.crossref.org/works/10.1093%2FTOXSCI%2FKFM100

21 January 2018

Identifiers

10.1093/TOXSCI/KFM100

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/17483121

ResearchGate publication ID

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