(Q53246017)

English

Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis.

scientific article published in January 2002

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scholarly article

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Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/11784789

Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

cognitive dysfunction

1 reference

based on heuristic

inferred from title

John Q. Trojanowski

8

object named as

John Q Trojanowski

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

author name string

Kunihiro Uryu

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

Helmut Laurer

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

Tracy McIntosh

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

Domenico Praticò

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

Daniel Martinez

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

Susan Leight

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

Virginia M-Y Lee

7

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

language of work or name

0 references

publication date

1 January 2002

1 reference

Europe PubMed Central

PubMed publication ID

12 May 2018

http://europepmc.org/abstract/MED/11784789

Journal of Neuroscience

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

22

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

446-454

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

Oxidative alterations in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Altered cleavage and secretion of a recombinant beta-APP bearing the Swedish familial Alzheimer's disease mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased 8,12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head injury as a risk factor for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Down's syndrome is associated with increased 8,12-iso-iPF2alpha-VI levels: evidence for enhanced lipid peroxidation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The amino acid sequence of neuritic plaque amyloid from a familial Alzheimer's disease patient.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease: a study of epidemiological aspects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated accumulation of amyloid beta proteins on oxidatively damaged lipid membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

GM1 ganglioside-bound amyloid beta-protein (A beta): a possible form of preamyloid in Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Key factors in Alzheimer's disease: beta-amyloid precursor protein processing, metabolism and intraneuronal transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Place navigation impaired in rats with hippocampal lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutant genes in familial Alzheimer's disease and transgenic models

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Progressive atrophy and neuron death for one year following brain trauma in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Head injury and the risk of AD in the MIRAGE study

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A controlled cortical impact model of traumatic brain injury in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Traumatic brain injury in the rat: characterization of a midline fluid-percussion model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased vulnerability of NFH-LacZ transgenic mouse to traumatic brain injury-induced behavioral deficits and cortical damage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neurons regulate extracellular levels of amyloid beta-protein via proteolysis by insulin-degrading enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's disease as proteolytic disorders: anabolism and catabolism of beta-amyloid

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Translating cell biology into therapeutic advances in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alzheimer's beta-amyloid peptide specifically interacts with and is degraded by insulin degrading enzyme

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential acute and chronic responses of tumor necrosis factor-deficient mice to experimental brain injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular basis of the neurodegenerative disorders

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

F(2)-isoprostanes: sensitive and specific non-invasive indices of lipid peroxidation in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of APP cleavage by alpha-, beta- and gamma-secretases

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mild head injury increasing the brain's vulnerability to a second concussive impact.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal cytoskeletal changes are an early consequence of repetitive head injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of traumatic brain injury on mouse spatial and nonspatial learning in the Barnes circular maze.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Brain trauma in aged transgenic mice induces regression of established abeta deposits

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BCL-2 overexpression attenuates cortical cell loss after traumatic brain injury in transgenic mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro and in vivo oxidative stress associated with Alzheimer's amyloid beta-peptide (1-42)

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid, the presenilins and Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular pathology of head trauma: altered beta APP metabolism and the aetiology of Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Traumatic brain injury in young, amyloid-beta peptide overexpressing transgenic mice induces marked ipsilateral hippocampal atrophy and diminished Abeta deposition during aging.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of amyloid precursor protein cleavage.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of "molecular shrapnel" for Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Documented head injury in early adulthood and risk of Alzheimer's disease and other dementias

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Postinjury treatment with magnesium chloride attenuates cortical damage after traumatic brain injury in rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuronal oxidative stress precedes amyloid-beta deposition in Down syndrome

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased lipid peroxidation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of the major Abeta1-42-degrading catabolic pathway in brain parenchyma: suppression leads to biochemical and pathological deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/11784789

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.22-02-00446.2002

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6758680&resulttype=core&format=json

12 May 2020

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