(Q53341531)

13 May 2018

title

Electrophilic chemicals but not UV irradiation or reactive oxygen species activate Nrf2 in keratinocytes in vitro and in vivo. (English)

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13 May 2018

main subject

reactive oxygen species

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1 reference

Ulrich auf dem Keller

6

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13 May 2018

Sabine Werner

5

object named as

Sabine Werner

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13 May 2018

Moritz Durchdewald

1

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13 May 2018

Tobias A Beyer

2

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13 May 2018

Delinda A Johnson

3

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13 May 2018

Jeffrey A Johnson

4

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13 May 2018

language of work or name

English

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publication date

28 September 2006

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13 May 2018

Journal of Investigative Dermatology

published in

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13 May 2018

volume

127

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13 May 2018

issue

3

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13 May 2018

page(s)

646-653

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13 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.jid.5700585

exact match

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cites work

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Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing

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Involvement of reactive oxygen species in the metabolic pathways triggered by diesel exhaust particles in human airway epithelial cells

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Nrf2 transcription factor, a novel target of keratinocyte growth factor action which regulates gene expression and inflammation in the healing skin wound

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Long-term culture of murine epidermal keratinocytes

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NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

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7 January 2021

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

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Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

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Signaling pathways and intracellular targets of sulforaphane mediating cell cycle arrest and apoptosis

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Ultraviolet A irradiation induces NF-E2-related factor 2 activation in dermal fibroblasts: protective role in UVA-induced apoptosis

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7 January 2021

Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

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Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2)

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7 January 2021

Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

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7 January 2021

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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7 January 2021

Nrf2 signaling in coordinated activation of antioxidant gene expression

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7 January 2021

Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice

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7 January 2021

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

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7 January 2021

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

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7 January 2021

Nrf2-dependent activation of the antioxidant responsive element by tert-butylhydroquinone is independent of oxidative stress in IMR-32 human neuroblastoma cells

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7 January 2021

Stimulatory effect of thapsigargin, a non-TPA-type tumor promoter, on arachidonic acid metabolism in the murine keratinocyte line HEL30 and on epidermal cell proliferation in vivo as compared to the effects of phorbol ester TPA.

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

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7 January 2021

Pivotal role of electrophilicity in glutathione S-transferase induction by tert-butylhydroquinone

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7 January 2021

The pathways and molecular mechanisms regulating Nrf2 activation in response to chemical stress

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7 January 2021

NADPH oxidase and ERK signaling regulates hyperoxia-induced Nrf2-ARE transcriptional response in pulmonary epithelial cells

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7 January 2021

Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma

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7 January 2021

Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide

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7 January 2021

The glutathione conjugates of tert-butyl hydroquinone as potent redox cycling agents and possible reactive agents underlying the toxicity of butylated hydroxyanisole

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7 January 2021

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

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7 January 2021

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

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7 January 2021

ets-1 is transcriptionally up-regulated by H2O2 via an antioxidant response element

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https://api.crossref.org/works/10.1038%2FSJ.JID.5700585

7 January 2021

Long-term culture of adult murine epidermal keratinocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5700585

7 January 2021

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.JID.5700585

7 January 2021

Identifiers

DOI

10.1038/SJ.JID.5700585

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13 May 2018

PubMed ID

17008872

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13 May 2018