(Q53345928)

13 May 2018

title

Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation. (English)

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13 May 2018

1 reference

X Wang

1

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13 May 2018

Y-X Zhou

2

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13 May 2018

W Qiao

3

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13 May 2018

Y Tominaga

4

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13 May 2018

M Ouchi

5

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13 May 2018

T Ouchi

6

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13 May 2018

C-X Deng

7

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13 May 2018

language of work or name

English

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publication date

22 May 2006

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13 May 2018

published in

Oncogene

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13 May 2018

volume

25

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13 May 2018

issue

54

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13 May 2018

page(s)

7148-7158

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13 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.onc.1209707

exact match

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cites work

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AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol

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G2 and spindle assembly checkpoint adaptation, and tetraploidy arrest: implications for intrinsic and chemically induced genomic instability

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Prognostic relevance of 20q13 gains in sporadic colorectal cancers: a FISH analysis

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Drosophila Aurora-A is required for centrosome maturation and actin-dependent asymmetric protein localization during mitosis

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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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Relationship between estrogen levels, use of hormone replacement therapy, and breast cancer

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Aurora A, meiosis and mitosis

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Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

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Mechanisms and consequences of activation of protein kinase B/Akt

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Aurora kinases in spindle assembly and chromosome segregation

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Checkpoint protein BubR1 acts synergistically with Mad2 to inhibit anaphase-promoting complex

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Breast cancer and sex steroids: critical review of epidemiological, experimental and clinical investigations on etiopathogenesis, chemoprevention and endocrine treatment of breast cancer

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Drosophila Aurora A kinase is required to localize D-TACC to centrosomes and to regulate astral microtubules.

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Aurora kinases, aneuploidy and cancer, a coincidence or a real link?

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Cyclin D1 over-expression correlates with beta-catenin activation, but not with H-ras mutations, and phosphorylation of Akt, GSK3 beta and ERK1/2 in mouse hepatic carcinogenesis.

21 January 2018

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Aurora-A kinase is required for centrosome maturation in Caenorhabditis elegans

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Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells

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The Aurora kinases: role in cell transformation and tumorigenesis

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Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53.

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Regulation of Aurora-A kinase on the mitotic spindle

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Aurora-A abrogation of p53 DNA binding and transactivation activity by phosphorylation of serine 215.

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Roles of aurora-A kinase in mitotic entry and G2 checkpoint in mammalian cells.

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Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells

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Aurora kinases link chromosome segregation and cell division to cancer susceptibility

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MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

21 January 2018

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Mammalian target of rapamycin: a new molecular target for breast cancer

21 January 2018

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Transcriptional control of BubR1 by p53 and suppression of centrosome amplification by BubR1

21 January 2018

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BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition

21 January 2018

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Estrogen regulation of cell cycle progression in breast cancer cells

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Phospho-akt expression is associated with a favorable outcome in non-small cell lung cancer

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Dynamic association of a tumor amplified kinase, Aurora‐A, with the centrosome and mitotic spindle

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Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2

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The clinical significance of Aurora-A/STK15/BTAK expression in human esophageal squamous cell carcinoma.

21 January 2018

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Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1.

21 January 2018

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A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint

21 January 2018

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Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells

21 January 2018

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Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

21 January 2018

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Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation

21 January 2018

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Variable levels of chromosomal instability and mitotic spindle checkpoint defects in breast cancer

21 January 2018

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Cre-loxP-controlled periodic Aurora-A overexpression induces mitotic abnormalities and hyperplasia in mammary glands of mouse models

21 January 2018

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Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

21 January 2018

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Genomic convergence and suppression of centrosome hyperamplification in primary p53-/- cells in prolonged culture

21 January 2018

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7 January 2021

Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209707

7 January 2021

p53 and ATM: cell cycle, cell death, and cancer.

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7 January 2021

Amplification/overexpression of a mitotic kinase gene in human bladder cancer

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209707

1 reference

13 May 2018

1 reference

13 May 2018