(Q53372846)

13 May 2018

review article

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title

Merlin and ERM proteins: unappreciated roles in cancer development? (English)

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13 May 2018

author name string

Andrea I McClatchey

series ordinal

1

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13 May 2018

language of work or name

English

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publication date

1 November 2003

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13 May 2018

published in

Nature Reviews Cancer

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13 May 2018

volume

3

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13 May 2018

page(s)

877-883

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13 May 2018

issue

11

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13 May 2018

https://scigraph.springernature.com/pub.10.1038/nrc1213

exact match

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cites work

A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.

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Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2

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The Nf2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation

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Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors

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Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse

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Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout

31 March 2020

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Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes

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ERM proteins and merlin: integrators at the cell cortex

31 March 2020

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Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes

31 March 2020

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Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells

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Ezrin-dependent promotion of glioma cell clonogenicity, motility, and invasion mediated by BCL-2 and transforming growth factor-beta2.

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High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential

31 March 2020

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Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin

31 March 2020

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The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane

31 March 2020

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Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin

31 March 2020

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Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.

31 March 2020

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Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane

31 March 2020

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Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain

31 March 2020

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Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets

31 March 2020

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Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association

31 March 2020

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Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor

31 March 2020

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Increased ezrin expression and activation by CDK5 coincident with acquisition of the senescent phenotype.

31 March 2020

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Identification of a phosphatidylinositol-4,5-bisphosphate-binding domain in the N-terminal region of ezrin

31 March 2020

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Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli

31 March 2020

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The Nf2 tumor suppressor, merlin, functions in Rac-dependent signaling.

31 March 2020

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Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization

31 March 2020

1 reference

Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF

31 March 2020

1 reference

Interaction between two isoforms of the NF2 tumor suppressor protein, merlin, and between merlin and ezrin, suggests modulation of ERM proteins by merlin.

31 March 2020

1 reference

Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP.

31 March 2020

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Rho GTPases in cell biology

31 March 2020

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RhoA-dependent phosphorylation and relocalization of ERM proteins into apical membrane/actin protrusions in fibroblasts

31 March 2020

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Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization

31 March 2020

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p21-activated kinase links Rac/Cdc42 signaling to merlin

31 March 2020

1 reference

Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity

31 March 2020

1 reference

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

31 March 2020

1 reference

Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins

31 March 2020

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Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl

31 March 2020

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Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein

31 March 2020

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Expression level, subcellular distribution and rho-GDI binding affinity of merlin in comparison with Ezrin/Radixin/Moesin proteins

31 March 2020

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31 March 2020

RHO-GTPases and cancer

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Epidermal growth factor receptor expression in neurofibromatosis type 1-related tumors and NF1 animal models

31 March 2020

1 reference

The neurofibromatosis 2 tumor suppressor protein interacts with hepatocyte growth factor-regulated tyrosine kinase substrate

31 March 2020

1 reference

Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family

31 March 2020

1 reference

NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins

31 March 2020

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Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity

31 March 2020

1 reference

Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP

31 March 2020

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ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons

31 March 2020

1 reference

The NF2 tumor suppressor gene product, merlin, mediates contact inhibition of growth through interactions with CD44

31 March 2020

1 reference

CD44 is required for two consecutive steps in HGF/c-Met signaling.

31 March 2020

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Interaction between the adhesion receptor, CD44, and the oncogene product, p185HER2, promotes human ovarian tumor cell activation

31 March 2020

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CD44 enhances neuregulin signaling by Schwann cells

31 March 2020

1 reference

Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology

31 March 2020

1 reference

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

31 March 2020

1 reference

Ezrin regulates E-cadherin-dependent adherens junction assembly through Rac1 activation

31 March 2020

1 reference

The role of the E-cadherin/catenin adhesion complex in the development and progression of cancer.

31 March 2020

1 reference

Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148

31 March 2020

1 reference

Epithelial-mesenchymal transitions in tumour progression

31 March 2020

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Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

31 March 2020

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Mutant products of the NF2 tumor suppressor gene are degraded by the ubiquitin-proteasome pathway

31 March 2020

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The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

31 March 2020

1 reference

Clinical features and pathobiology of neurofibromatosis 1.

31 March 2020

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Nodes of Ranvier form in association with ezrin-radixin-moesin (ERM)-positive Schwann cell processes

31 March 2020

1 reference

Ezrin, radixin, and moesin are components of Schwann cell microvilli

31 March 2020

1 reference

The distal pole complex: a novel membrane domain distal to the immunological synapse

31 March 2020

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A role for moesin in polarity

31 March 2020

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Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton

31 March 2020

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Association of Caspr/paranodin with tumour suppressor schwannomin/merlin and beta1 integrin in the central nervous system

31 March 2020

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Interdomain binding mediates tumor growth suppression by the NF2 gene product

31 March 2020

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Cellular transformation by a FERM domain mutant of the Nf2 tumor suppressor gene

31 March 2020

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Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC1213

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13 May 2018

PubMed ID

14668818

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13 May 2018