(Q53388749)

13 May 2018

title

Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain. (English)

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13 May 2018

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5

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13 May 2018

author name string

Jesse C Wiley

1

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13 May 2018

Elise A Smith

2

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13 May 2018

Mark P Hudson

3

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13 May 2018

Warren C Ladiges

4

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13 May 2018

language of work or name

English

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publication date

11 September 2007

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13 May 2018

Journal of Biological Chemistry

published in

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13 May 2018

volume

282

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13 May 2018

issue

46

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13 May 2018

page(s)

33313-33325

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13 May 2018

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein

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Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

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A {gamma}-secretase-independent mechanism of signal transduction by the amyloid precursor protein

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A dominant role for FE65 (APBB1) in nuclear signaling

21 January 2018

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The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

21 January 2018

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The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled

21 January 2018

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The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

21 January 2018

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FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein.

21 January 2018

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The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing

21 January 2018

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Regulation of beta-amyloid secretion by FE65, an amyloid protein precursor-binding protein

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The human FE65 gene: genomic structure and an intronic biallelic polymorphism associated with sporadic dementia of the Alzheimer type

21 January 2018

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A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type

21 January 2018

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A FE65 polymorphism associated with risk of developing sporadic late-onset alzheimer's disease but not with Abeta loading in brains

21 January 2018

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Alternatively spliced isoforms of FE65 serve as neuron-specific and non-neuronal markers

21 January 2018

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Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment

21 January 2018

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Endoproteolytic cleavage of FE65 converts the adaptor protein to a potent suppressor of the sAPPalpha pathway in primates

21 January 2018

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Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

21 January 2018

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A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor

21 January 2018

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Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein

21 January 2018

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Isoform-specific knockout of FE65 leads to impaired learning and memory

21 January 2018

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hFE65L influences amyloid precursor protein maturation and secretion

21 January 2018

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gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins

21 January 2018

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

21 January 2018

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Broadly altered expression of the mRNA isoforms of FE65, a facilitator of beta amyloidogenesis, in Alzheimer cerebellum and other brain regions.

21 January 2018

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Candidate genes showing no evidence for association or linkage with Alzheimer's disease using family-based methodologies.

21 January 2018

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Lack of replication of association findings in complex disease: an analysis of 15 polymorphisms in prior candidate genes for sporadic Alzheimer's disease

21 January 2018

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Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

21 January 2018

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Generation of the β-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment γ Are Potentiated by FE65L1

21 January 2018

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Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network

21 January 2018

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

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The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

21 January 2018

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Interaction of Tau with Fe65 links tau to APP

21 January 2018

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The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1

21 January 2018

1 reference

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Expression of human FE65 in amyloid precursor protein transgenic mice is associated with a reduction in beta-amyloid load.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706024200

The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706024200

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

21 January 2018

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Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706024200

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

21 January 2018

1 reference

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Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

21 January 2018

1 reference

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Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

21 January 2018

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FE65 Interaction with the ApoE Receptor ApoEr2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706024200

21 January 2018

Identifiers

DOI

10.1074/JBC.M706024200

1 reference

13 May 2018

PubMed ID

17855370

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13 May 2018