(Q53396593)

English

Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism.

scientific article published on 4 August 2015

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20 February 2020

Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism (English)

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20 February 2020

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evasion of host immune response

1 reference

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Klaus H Metzeler

9

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20 February 2020

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20 February 2020

Irmela Jeremias

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20 February 2020

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C Krupka

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20 February 2020

P Kufer

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20 February 2020

R Kischel

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20 February 2020

G Zugmaier

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20 February 2020

F S Lichtenegger

5

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20 February 2020

T Köhnke

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20 February 2020

T Altmann

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20 February 2020

S Schneider

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20 February 2020

M Fiegl

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20 February 2020

K Spiekermann

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20 February 2020

P A Bauerle

14

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20 February 2020

W Hiddemann

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20 February 2020

G Riethmüller

16

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20 February 2020

M Subklewe

17

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20 February 2020

publication date

4 August 2015

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20 February 2020

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20 February 2020

30

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20 February 2020

2

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20 February 2020

484-491

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20 February 2020

https://scigraph.springernature.com/pub.10.1038/leu.2015.214

0 references

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1 reference

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Cutaneous T cell lymphoma cells are targets for immune checkpoint ligand PD-L1-specific, cytotoxic T cells.

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1 reference

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The targeting of immunosuppressive mechanisms in hematological malignancies

1 reference

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21 January 2018

In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

Interferon-induced programmed death-ligand 1 (PD-L1/B7-H1) expression increases on human acute myeloid leukemia blast cells during treatment.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

Clinical significance of B7-H1 (PD-L1) expression in human acute leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

PD-1/PD-L1 interactions contribute to functional T-cell impairment in patients who relapse with cancer after allogeneic stem cell transplantation.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

Bispecific T-cell engaging antibodies for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

Cellular determinants for preclinical activity of a novel CD33/CD3 bispecific T-cell engager (BiTE) antibody, AMG 330, against human AML.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

T lymphocytes can be effectively recruited for ex vivo and in vivo lysis of AML blasts by a novel CD33/CD3-bispecific BiTE antibody construct.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

Regression of human prostate cancer xenografts in mice by AMG 212/BAY2010112, a novel PSMA/CD3-Bispecific BiTE antibody cross-reactive with non-human primate antigens.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

T cell-engaging BiTE antibodies specific for EGFR potently eliminate KRAS- and BRAF-mutated colorectal cancer cells

1 reference

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21 January 2018

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging

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21 January 2018

Safety and activity of blinatumomab for adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia: a multicentre, single-arm, phase 2 study

1 reference

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21 January 2018

The past and future of CD33 as therapeutic target in acute myeloid leukemia.

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Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment

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21 January 2018

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

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https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

Expression of indoleamine 2,3-dioxygenase in acute myeloid leukemia and the effect of its inhibition on cultured leukemia blast cells

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https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

Colocalization of inflammatory response with B7-h1 expression in human melanocytic lesions supports an adaptive resistance mechanism of immune escape

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2015.214

21 January 2018

Efficient elimination of chronic lymphocytic leukaemia B cells by autologous T cells with a bispecific anti-CD19/anti-CD3 single-chain antibody construct

1 reference

https://pubmed.ncbi.nlm.nih.gov/26239198

12 December 2020

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Overall Survival and Long-Term Safety of Nivolumab (Anti-Programmed Death 1 Antibody, BMS-936558, ONO-4538) in Patients With Previously Treated Advanced Non-Small-Cell Lung Cancer

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Flow cytometric analysis of different CD14 epitopes can help identify immature monocytic populations

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12 December 2020

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inferred from PubMed ID database lookup

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1 reference

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12 December 2020

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1 reference

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1 reference

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1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Identifiers

10.1038/LEU.2015.214

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26239198%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26239198%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

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