(Q53413637)

14 May 2018

title

Epistasis buffers the fitness effects of rifampicin- resistance mutations in Pseudomonas aeruginosa. (English)

1 reference

14 May 2018

main subject

Pseudomonas aeruginosa

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author name string

Alex R Hall

series ordinal

1

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14 May 2018

R Craig MacLean

series ordinal

2

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14 May 2018

publication date

10 May 2011

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14 May 2018

number of pages

10

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based on heuristic

inferred from page(s)

published in

Evolution

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14 May 2018

volume

65

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14 May 2018

issue

8

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14 May 2018

page(s)

2370-2379

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14 May 2018

Evolution of antifungal-drug resistance: mechanisms and pathogen fitness

cites work

1 reference

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Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance

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1 reference

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Structural mechanism for rifampicin inhibition of bacterial rna polymerase

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1 reference

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Compensatory mutations are repeatable and clustered within proteins.

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A constant rate of spontaneous mutation in DNA-based microbes

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Enzyme activity and fitness: Evolution in solution

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The competitive cost of antibiotic resistance in Mycobacterium tuberculosis

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Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosome

21 January 2018

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The evolution of epistasis and its links with genetic robustness, complexity and drift in a phenotypic model of adaptation

21 January 2018

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Characterization of the pleiotropic phenotypes of rifampin-resistant rpoB mutants of Escherichia coli

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Reduction of the fitness burden of quinolone resistance in Pseudomonas aeruginosa

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Amino acid changes in conserved regions of the beta-subunit of Escherichia coli RNA polymerase alter transcription pausing and termination.

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Biological cost of single and multiple norfloxacin resistance mutations in Escherichia coli implicated in urinary tract infections.

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The epidemiological fitness cost of drug resistance in Mycobacterium tuberculosis.

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The distribution of fitness effects of beneficial mutations in Pseudomonas aeruginosa

21 January 2018

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Diminishing returns from beneficial mutations and pervasive epistasis shape the fitness landscape for rifampicin resistance in Pseudomonas aeruginosa

21 January 2018

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Adaptation to the deleterious effects of antimicrobial drug resistance mutations by compensatory evolution

21 January 2018

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Compensatory evolution reveals functional interactions between ribosomal proteins S12, L14 and L19.

21 January 2018

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Interplay in the selection of fluoroquinolone resistance and bacterial fitness

21 January 2018

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Effect of rpoB mutations conferring rifampin resistance on fitness of Mycobacterium tuberculosis

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Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes

21 January 2018

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Molecular genetic and structural modeling studies of Staphylococcus aureus RNA polymerase and the fitness of rifampin resistance genotypes in relation to clinical prevalence

21 January 2018

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Multiple mechanisms to ameliorate the fitness burden of mupirocin resistance in Salmonella typhimurium.

21 January 2018

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Uncovering new metabolic capabilities of Bacillus subtilis using phenotype profiling of rifampin-resistant rpoB mutants

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Rapid decline of fitness in panmictic populations of Drosophila melanogaster maintained under relaxed natural selection.

21 January 2018

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Environmental stress and mutational load in diploid strains of the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

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Positive epistasis drives the acquisition of multidrug resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1558-5646.2011.01302.X

Structural perspective on mutations affecting the function of multisubunit RNA polymerases

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1558-5646.2011.01302.X

The cost of multiple drug resistance in Pseudomonas aeruginosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1558-5646.2011.01302.X

Darwinian evolution can follow only very few mutational paths to fitter proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1558-5646.2011.01302.X

Mutational neighbourhood and mutation supply rate constrain adaptation in Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1558-5646.2011.01302.X

Interaction between directional epistasis and average mutational effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1558-5646.2011.01302.X

10.1111/J.1558-5646.2011.01302.X

21 January 2018

Identifiers

DOI

1 reference

14 May 2018

1 reference

14 May 2018