(Q53538448)

15 May 2018

title

A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes. (English)

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15 May 2018

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Tanja Arndt

1

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15 May 2018

Dirk Wedekind

2

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15 May 2018

Anne Jörns

3

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15 May 2018

Georgios Tsiavaliaris

4

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15 May 2018

Edwin Cuppen

5

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15 May 2018

Hans-Jürgen Hedrich

6

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15 May 2018

Sigurd Lenzen

7

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15 May 2018

publication date

12 September 2015

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15 May 2018

published in

Diabetologia

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15 May 2018

volume

58

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15 May 2018

issue

12

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15 May 2018

page(s)

2800-2809

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15 May 2018

https://scigraph.springernature.com/pub.10.1007/s00125-015-3757-7

exact match

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cites work

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Rat models of type 1 diabetes: genetics, environment, and autoimmunity

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The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus

21 January 2018

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Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes

21 January 2018

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Effects of polyinosinic-polycytidylic acid and adoptive transfer of immune cells in the Lew.1AR1-iddm rat and in its coisogenic LEW.1AR1 background strain

21 January 2018

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Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation

21 January 2018

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Susceptibility to diabetes is widely distributed in normal class IIu haplotype rats.

21 January 2018

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The mutation of the LEW.1AR1-iddm rat maps to the telomeric end of rat chromosome 1.

21 January 2018

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A genome-wide SNP panel for mapping and association studies in the rat.

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DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses

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Isolation and characterisation of DOCK8, a member of the DOCK180-related regulators of cell morphology

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Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor

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Combined immunodeficiency associated with DOCK8 mutations

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Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor

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IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family

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GEF what? Dock180 and related proteins help Rac to polarize cells in new ways

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Dedicator of cytokinesis 8 (DOCK8) deficiency

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The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.

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Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing

21 January 2018

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A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress

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DOCK2 regulates Rac activation and cytoskeletal reorganization through interaction with ELMO1

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CZH proteins: a new family of Rho-GEFs

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Cellular signaling for activation of Rho GTPase Cdc42.

21 January 2018

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DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory

21 January 2018

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Dedicator of cytokinesis 8 interacts with talin and Wiskott-Aldrich syndrome protein to regulate NK cell cytotoxicity

21 January 2018

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DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation

21 January 2018

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Defective actin accumulation impairs human natural killer cell function in patients with dedicator of cytokinesis 8 deficiency.

21 January 2018

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Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

21 January 2018

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DOCK8 is critical for the survival and function of NKT cells

21 January 2018

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21 January 2018

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Zizimin2: a novel, DOCK180-related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes

21 January 2018

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Dock10, a novel CZH protein selectively induced by interleukin-4 in human B lymphocytes

21 January 2018

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Genetic dissection of autoimmune type I diabetes in the BB rat.

21 January 2018

1 reference

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Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-015-3757-7

Comparative analysis of the human gimap gene cluster encoding a novel GTPase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-015-3757-7

Lymphopenia in the BB rat model of type 1 diabetes is due to a mutation in a novel immune-associated nucleotide (Ian)-related gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-015-3757-7

New Inbred Strain of Long-Evans Tokushima Lean Rats With IDDM Without Lymphopenia

21 January 2018

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12 December 2020

Cblb is a major susceptibility gene for rat type 1 diabetes mellitus

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12 December 2020

Cutting Edge: Regulation of T Cell Activation Threshold by CD28 Costimulation Through Targeting Cbl-b for Ubiquitination

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12 December 2020

A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat.

1 reference

12 December 2020

Immune cell infiltration, cytokine expression, and beta-cell apoptosis during the development of type 1 diabetes in the spontaneously diabetic LEW.1AR1/Ztm-iddm rat

1 reference

12 December 2020

Anti-TCR therapy combined with fingolimod for reversal of diabetic hyperglycemia by β cell regeneration in the LEW.1AR1-iddm rat model of type 1 diabetes

1 reference

12 December 2020

Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus

1 reference

12 December 2020

Large deletions and point mutations involving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome

1 reference

12 December 2020

10.1007/S00125-015-3757-7

Identifiers

DOI

1 reference

15 May 2018

PubMed ID

26363782

1 reference

15 May 2018