(Q53546426)

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The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18343822%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18343822%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

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4 January 2020

6

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4 January 2020

Thomas J.D. Jørgensen

4

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4 January 2020

Henning R Stennicke

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Henning R Stennicke

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4 January 2020

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Mette D Andersen

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4 January 2020

Ole H Olsen

3

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4 January 2020

Henrik Ostergaard

5

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18343822%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

Egon Persson

8

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4 January 2020

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14 March 2008

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4 January 2020

Journal of Biological Chemistry

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18343822%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

283

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4 January 2020

19

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4 January 2020

13378-13387

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18343822%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

The molecular basis of blood coagulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

The coagulation cascade: initiation, maintenance, and regulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Mechanism of charge compensation and impairment of co-operative functions in haemoglobin Tacoma (Arg B12(30)β → ser)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Structural basis of the activation and action of trypsin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Structure of human factor VIIa and its implications for the triggering of blood coagulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Treatment of traumatic bleeding with recombinant factor VIIa.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Platelet activity of high-dose factor VIIa is independent of tissue factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

The use of recombinant factor VIIa in the treatment of bleeding disorders.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Substitution of aspartic acid for methionine-306 in factor VIIa abolishes the allosteric linkage between the active site and the binding interface with tissue factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Augmented intrinsic activity of Factor VIIa by replacement of residues 305, 314, 337 and 374: evidence of two unique mutational mechanisms of activity enhancement

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Rational design of coagulation factor VIIa variants with substantially increased intrinsic activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Factor VIIa analogue (V158D/E296V/M298Q-FVIIa) normalises clot formation in whole blood from patients with severe haemophilia A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor VIIa

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Hydrogen exchange mass spectrometry for the analysis of protein dynamics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

A combined structural dynamics approach identifies a putative switch in factor VIIa employed by tissue factor to initiate blood coagulation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Primary structure effects on peptide group hydrogen exchange

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Identification of a calcium binding site in the protease domain of human blood coagulation factor VII: evidence for its role in factor VII-tissue factor interaction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Allosteric regulation of the cofactor-dependent serine protease coagulation factor VIIa.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Role of zymogenicity-determining residues of coagulation factor VII/VIIa in cofactor interaction and macromolecular substrate recognition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Binding of Zn2+ to a Ca2+ loop allosterically attenuates the activity of factor VIIa and reduces its affinity for tissue factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

Incorporation of an active site inhibitor in factor VIIa alters the affinity for tissue factor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M709716200

21 January 2018

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