(Q53575629)

English

Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells.

scientific article published on 13 March 2007

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scholarly article

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

Protein kinase C-mediated down-regulation of cyclin D1 involves activation of the translational repressor 4E-BP1 via a phosphoinositide 3-kinase/Akt-independent, protein phosphatase 2A-dependent mechanism in intestinal epithelial cells. (English)

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

author name string

Lingjie Guan

1

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

Kyung Song

2

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

Marybeth A Pysz

3

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

Kathryn J Curry

4

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

A Asli Hizli

5

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

David Danielpour

6

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

Adrian R Black

7

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

Jennifer D Black

8

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

language of work or name

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publication date

13 March 2007

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

Journal of Biological Chemistry

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Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

282

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Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

14213-14225

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Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

19

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

The isoform-specific regulation of apoptosis by protein kinase C.

1 reference

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21 January 2018

Regulation of cell apoptosis by protein kinase c delta

1 reference

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21 January 2018

PKC epsilon controls the traffic of beta1 integrins in motile cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein kinase C alpha signaling inhibits cyclin D1 translation in intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Functional interaction between RAFT1/FRAP/mTOR and protein kinase cdelta in the regulation of cap-dependent initiation of translation

1 reference

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21 January 2018

Regulation of membrane trafficking and endocytosis by protein kinase C: emerging role of the pericentrion, a novel protein kinase C-dependent subset of recycling endosomes

1 reference

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21 January 2018

The role of protein kinase C in gastrointestinal function and disease

1 reference

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21 January 2018

Protein kinase C isozymes in colon carcinogenesis: guilt by omission.

1 reference

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21 January 2018

Protein kinase C signaling mediates a program of cell cycle withdrawal in the intestinal epithelium

1 reference

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21 January 2018

Involvement of the ERK signaling cascade in protein kinase C-mediated cell cycle arrest in intestinal epithelial cells

1 reference

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21 January 2018

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

1 reference

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21 January 2018

eIF-4E expression and its role in malignancies and metastases.

1 reference

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21 January 2018

Regulation of translation initiation by FRAP/mTOR

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Upstream and downstream of mTOR

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21 January 2018

Regulation of protein synthesis by insulin

1 reference

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21 January 2018

Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

1 reference

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21 January 2018

The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

1 reference

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21 January 2018

Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase

1 reference

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21 January 2018

Regulation of protein kinase B and 4E-BP1 by oxidative stress in cardiac myocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

A redox-triggered ras-effector interaction. Recruitment of phosphatidylinositol 3'-kinase to Ras by redox stress.

1 reference

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21 January 2018

Novel roles of Akt and mTOR in suppressing TGF-beta/ALK5-mediated Smad3 activation

1 reference

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21 January 2018

Involvement of protein kinase C delta (PKCdelta) in phorbol ester-induced apoptosis in LNCaP prostate cancer cells. Lack of proteolytic cleavage of PKCdelta

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

VCAM-1 signals activate endothelial cell protein kinase Calpha via oxidation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Priming of alveolar macrophage respiratory burst by H(2)O(2) is prevented by phosphatidylcholine-specific phospholipase C inhibitor Tricyclodecan-9-yl-xanthate (D609).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Activation of protein kinase C by tyrosine phosphorylation in response to H2O2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Diacylglycerol generated during sphingomyelin synthesis is involved in protein kinase C activation and cell proliferation in Madin-Darby canine kidney cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Ceramide induces translocation of protein kinase C-alpha to the Golgi compartment of human embryonic kidney cells by interacting with the C2 domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

The extracellular signal-regulated kinase pathway regulates the phosphorylation of 4E-BP1 at multiple sites

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Eyes wide shut: protein kinase C isozymes are not the only receptors for the phorbol ester tumor promoters

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

The phosphoinositide 3-kinase pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

The Akt/PKB pathway: molecular target for cancer drug discovery

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

AKT plays a central role in tumorigenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Osmotic shock inhibits insulin signaling by maintaining Akt/protein kinase B in an inactive dephosphorylated state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Stimulation of hepatocytic AMP-activated protein kinase by okadaic acid and other autophagy-suppressive toxins.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

A quantitative molecular model for modulation of mammalian translation by the eIF4E-binding protein 1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Lipid peroxide-induced redox imbalance differentially mediates CaCo-2 cell proliferation and growth arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

The Akt pathway: molecular targets for anti-cancer drug development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein kinase C modulates the insulin-stimulated increase in Akt1 and Akt3 activity in 3T3-L1 adipocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Lysophosphatidylcholine inhibits insulin-induced Akt activation through protein kinase C-alpha in vascular smooth muscle cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Negative impact of DEP exposure on human airway epithelial cell adhesion, stiffness, and repair

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein kinase C negatively regulates Akt activity and modifies UVC-induced apoptosis in mouse keratinocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

PKCalpha reduces the lipid kinase activity of the p110alpha/p85alpha PI3K through the phosphorylation of the catalytic subunit.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Insulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteins

1 reference

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21 January 2018

Modulation of human insulin receptor substrate-1 tyrosine phosphorylation by protein kinase Cdelta

1 reference

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21 January 2018

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

1 reference

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21 January 2018

Protein kinase B localization and activation differentially affect S6 kinase 1 activity and eukaryotic translation initiation factor 4E-binding protein 1 phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Cyclin D1 is not an immediate target of beta-catenin following Apc loss in the intestine

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

PP2A: the expected tumor suppressor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

1 reference

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21 January 2018

The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Alpha 4 associates with protein phosphatases 2A, 4, and 6

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Inhibition of cdc2 activation by INH/PP2A.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

PR72, a novel regulator of Wnt signaling required for Naked cuticle function

1 reference

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21 January 2018

Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Overexpression of the mTOR alpha4 phosphoprotein activates protein phosphatase 2A and increases Stat1alpha binding to PIAS1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

PP2A fulfills its promises as tumor suppressor: which subunits are important?

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Colonocyte differentiation is associated with increased expression and altered distribution of protein kinase C isozymes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Protein kinase C tissue localization in human colonic tumors suggests a role for adenoma growth control.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Five of six protein kinase C isoenzymes present in normal mucosa show reduced protein levels during tumor development in the human colon.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Eukaryotic translation initiation factor 4E regulates expression of cyclin D1 at transcriptional and post-transcriptional levels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Cyclin D1 genetic heterozygosity regulates colonic epithelial cell differentiation and tumor number in ApcMin mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610513200

21 January 2018

Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis

1 reference

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21 January 2018

Translational control of the proteome: relevance to cancer

1 reference

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21 January 2018

Inhibition of Myc-dependent apoptosis by eukaryotic translation initiation factor 4E requires cyclin D1.

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M610513200

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/17360714

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