(Q53588796)

English

Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.

scientific article published on 13 September 2006

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scholarly article

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells. (English)

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

0 references

protein ubiquitination

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Su Mi Choi

1

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

Kyung-Ok Choi

2

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

Young-Kwon Park

3

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

Hyunju Cho

4

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

Eun Gyeong Yang

5

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

Hyunsung Park

6

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

language of work or name

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publication date

13 September 2006

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

Journal of Biological Chemistry

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Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

281

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

45

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

34056-34063

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

The zinc chelator, N,N,N',N'-tetrakis (2-pyridylmethyl) ethylenediamine, increases the level of nonfunctional HIF-1alpha protein in normoxic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Metal ion-dependent effects of clioquinol on the fibril growth of an amyloid {beta} peptide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

An essential role for p300/CBP in the cellular response to hypoxia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Aqueous dissolution of Alzheimer's disease Abeta amyloid deposits by biometal depletion.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Structure of factor-inhibiting hypoxia-inducible factor 1: An asparaginyl hydroxylase involved in the hypoxic response pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Overexpression of Alzheimer's disease amyloid-beta opposes the age-dependent elevations of brain copper and iron.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Metals in our minds: therapeutic implications for neurodegenerative disorders

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Targeting HIF-1 for cancer therapy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Therapeutic angiogenesis in cardiovascular disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Hearts from rodents exposed to intermittent hypoxia or erythropoietin are protected against ischemia-reperfusion injury.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Localization of specific erythropoietin binding sites in defined areas of the mouse brain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Erythropoietin: novel approaches to neuroprotection in human brain disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

New roles for VEGF in nervous tissue--beyond blood vessels

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Transplantation of vascular endothelial growth factor-transfected neural stem cells into the rat brain provides neuroprotection after transient focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M603913200

21 January 2018

Identifiers

10.1074/JBC.M603913200

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

1 reference

Europe PubMed Central

15 May 2018

http://europepmc.org/abstract/MED/16973622

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