(Q53594506)

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Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells.

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Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells. (English)

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

1 reference

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Yvonne P Dragan

9

object named as

Yvonne P Dragan

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

author name string

Lei Guo

1

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

Lu Zhang

2

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

Yongming Sun

3

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

Levan Muskhelishvili

4

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

Ernice Blann

5

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

Stacey Dial

6

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

Leming Shi

7

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

Gary Schroth

8

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Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

publication date

1 August 2006

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Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

Molecular Diversity

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Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

10

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Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

3

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

349-360

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

https://scigraph.springernature.com/pub.10.1007/s11030-006-9038-0

0 references

Metabolic effects of troglitazone monotherapy in type 2 diabetes mellitus. A randomized, double-blind, placebo-controlled trial.

1 reference

https://api.crossref.org/works/10.1007%2FS11030-006-9038-0

21 January 2018

ArrayTrack--supporting toxicogenomic research at the U.S. Food and Drug Administration National Center for Toxicological Research

1 reference

https://api.crossref.org/works/10.1007%2FS11030-006-9038-0

21 January 2018

Development of public toxicogenomics software for microarray data management and analysis

1 reference

https://api.crossref.org/works/10.1007%2FS11030-006-9038-0

21 January 2018

Lack of effect of type II diabetes on the pharmacokinetics of troglitazone in a multiple-dose study.

1 reference

https://api.crossref.org/works/10.1007%2FS11030-006-9038-0

21 January 2018

Applications of microarrays with toxicologically relevant genes (tox genes) for the evaluation of chemical toxicants in Sprague Dawley rats in vivo and human hepatocytes in vitro

1 reference

https://api.crossref.org/works/10.1007%2FS11030-006-9038-0

21 January 2018

Cytotoxicity and apoptosis produced by troglitazone in human hepatoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

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Identification of toxicologically predictive gene sets using cDNA microarrays

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The PPARs: from orphan receptors to drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and evaluation of a new class of noncyclic 1,3-dicarbonyl compounds as PPARalpha selective activators.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic dysfunction associated with troglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of PPARgamma inhibits cell growth and induces apoptosis in human gastric cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microarray analysis in human hepatocytes suggests a mechanism for hepatotoxicity induced by trovafloxacin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BH3-only Bcl-2 family members are coordinately regulated by the JNK pathway and require Bax to induce apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A ligand for peroxisome proliferator activated receptor gamma inhibits cell growth and induces apoptosis in human liver cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Performance evaluation of commercial short-oligonucleotide microarrays and the impact of noise in making cross-platform correlations

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Second-generation thiazolidinediones and hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lessons from the glitazones: a story of drug development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of troglitazone hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spotted long oligonucleotide arrays for human gene expression analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Troglitazone but not rosiglitazone induces G1 cell cycle arrest and apoptosis in human and rat hepatoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatotoxicity of thiazolidinediones

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic failure in a patient taking rosiglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-induced acute liver failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential in vitro hepatotoxicity of troglitazone and rosiglitazone among cryopreserved human hepatocytes from 37 donors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxic effect of troglitazone on cultured rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and metabolic effects of metformin and troglitazone in type II diabetes mellitus.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

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inferred from PubMed ID database lookup

Analysis of matched mRNA measurements from two different microarray technologies

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Significance analysis of microarrays applied to the ionizing radiation response

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatotoxicity with thiazolidinediones: is it a class effect?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thiazolidenediones mediate apoptosis in prostate cancer cells in part through inhibition of Bcl-xL/Bcl-2 functions independently of PPARgamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fatal liver failure associated with pioglitazone

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of a low-speed, iso-density percoll centrifugation method to increase the viability of isolated rat hepatocyte preparations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

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Chapter 4 Preparation of Isolated Rat Liver Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17031537

12 December 2020

based on heuristic

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Identifiers

10.1007/S11030-006-9038-0

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

16 May 2018

http://europepmc.org/abstract/MED/17031537

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