(Q53611452)

16 May 2018

title

Does premature aging of the mtDNA mutator mouse prove that mtDNA mutations are involved in natural aging? (English)

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16 May 2018

4

Jan Vijg

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16 May 2018

author name string

Konstantin Khrapko

1

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16 May 2018

Yevgenya Kraytsberg

2

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16 May 2018

Aubrey D N J de Grey

3

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16 May 2018

Eric A Schon

5

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16 May 2018

publication date

1 June 2006

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16 May 2018

published in

Aging Cell

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16 May 2018

volume

5

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16 May 2018

issue

3

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16 May 2018

page(s)

279-282

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16 May 2018

A lifetime of retinal light exposure does not appear to increase mitochondrial mutations.

cites work

1 reference

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Essential role of limiting telomeres in the pathogenesis of Werner syndrome

21 January 2018

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Molecular analyses of mtDNA deletion mutations in microdissected skeletal muscle fibers from aged rhesus monkeys.

21 January 2018

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Aging and genome maintenance: lessons from the mouse?

21 January 2018

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Cytochrome c oxidase defects of the human substantia nigra in normal aging.

21 January 2018

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

21 January 2018

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DNA repair, genome stability, and aging

21 January 2018

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Mitochondrial DNA mutations, apoptosis, and the misfolded protein response.

21 January 2018

1 reference

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Clinical features associated with the A-->G transition at nucleotide 8344 of mtDNA ("MERRF mutation").

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00209.X

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00209.X

High frequency of mitochondrial complex I mutations in Parkinson's disease and aging

21 January 2018

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Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain

21 January 2018

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In vivo functional analysis of the human mitochondrial DNA polymerase POLG expressed in cultured human cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00209.X

Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00209.X

Premature ageing in mice expressing defective mitochondrial DNA polymerase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00209.X

Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00209.X

Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2006.00209.X

10.1111/J.1474-9726.2006.00209.X

21 January 2018

Identifiers

DOI

1 reference

16 May 2018

PubMed ID

16842501

1 reference

16 May 2018