(Q53620505)

30 June 2019

title

α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. (English)

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30 June 2019

Richard O Hynes

5

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author name string

Christopher J Turner

1

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30 June 2019

Kwabena Badu-Nkansah

2

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30 June 2019

Denise Crowley

3

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30 June 2019

Arjan van der Flier

4

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30 June 2019

language of work or name

English

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publication date

1 February 2015

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30 June 2019

number of pages

12

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inferred from page(s)

published in

Development

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30 June 2019

volume

142

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30 June 2019

issue

4

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30 June 2019

page(s)

797-808

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30 June 2019

The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

cites work

1 reference

12 December 2020

Fate of the mammalian cardiac neural crest

1 reference

12 December 2020

The extracellular matrix can regulate vascular cell migration, proliferation, and survival: relationships to vascular disease

1 reference

12 December 2020

Inflammatory cytokines stimulate vascular smooth muscle cells locomotion and growth by enhancing alpha5beta1 integrin expression and function.

1 reference

12 December 2020

Regional differences in integrin expression: role of alpha(5)beta(1) in regulating smooth muscle cell functions

1 reference

12 December 2020

Regulation of the L-type calcium channel by alpha 5beta 1 integrin requires signaling between focal adhesion proteins

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12 December 2020

Adhesion receptors of vascular smooth muscle cells and their functions.

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12 December 2020

The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling

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12 December 2020

The integrin alphaVbeta6 binds and activates latent TGFbeta3.

1 reference

12 December 2020

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure

1 reference

12 December 2020

Central Roles of α 5 β 1 Integrin and Fibronectin in Vascular Development in Mouse Embryos and Embryoid Bodies

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12 December 2020

The integrin alphavbeta3 is a receptor for the latency-associated peptides of transforming growth factors beta1 and beta3

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12 December 2020

Isolation of vascular smooth muscle cells from a single murine aorta

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12 December 2020

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

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12 December 2020

Integrin alpha5beta1 supports the migration of Xenopus cranial neural crest on fibronectin

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12 December 2020

Conditional inactivation of Tgfbr2 in cranial neural crest causes cleft palate and calvaria defects

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12 December 2020

Differential expression of integrin alpha5beta1 in human abdominal aortic aneurysm and healthy aortic tissues and its significance in pathogenesis

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12 December 2020

Transforming growth factor beta-SMAD2 signaling regulates aortic arch innervation and development

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12 December 2020

Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome

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12 December 2020

Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart

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12 December 2020

Integrin alpha4beta1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation

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12 December 2020

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12 December 2020

Role for the alpha7beta1 integrin in vascular development and integrity

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12 December 2020

Non-Smad TGF-beta signals

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12 December 2020

Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly

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12 December 2020

Defective blood vessel development and pericyte/pvSMC distribution in alpha 4 integrin-deficient mouse embryos

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12 December 2020

Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects

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12 December 2020

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

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12 December 2020

Absence of integrin-mediated TGFbeta1 activation in vivo recapitulates the phenotype of TGFbeta1-null mice

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12 December 2020

Complex hemodynamics at the apex of an arterial bifurcation induces vascular remodeling resembling cerebral aneurysm initiation.

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12 December 2020

Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment

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12 December 2020

The RGD motif in fibronectin is essential for development but dispensable for fibril assembly

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12 December 2020

Regulation and characteristics of vascular smooth muscle cell phenotypic diversity.

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12 December 2020

Cell-matrix adhesion in vascular development

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12 December 2020

Long form of latent TGF- binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling

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12 December 2020

A global double-fluorescent Cre reporter mouse

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12 December 2020

Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins

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12 December 2020

Extracellular control of TGFbeta signalling in vascular development and disease

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12 December 2020

Haemodynamics determined by a genetic programme govern asymmetric development of the aortic arch.

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12 December 2020

Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stability

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12 December 2020

The developmental genetics of congenital heart disease.

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12 December 2020

The flow field along the entire length of mouse aorta and primary branches

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12 December 2020

Developmental origin of smooth muscle cells in the descending aorta in mice.

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12 December 2020

Decrease of PECAM-1-gene-expression induced by proinflammatory cytokines IFN-gamma and IFN-alpha is reversed by TGF-beta in sinusoidal endothelial cells and hepatic mononuclear phagocytes

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12 December 2020

Absence of TGFbeta signaling in embryonic vascular smooth muscle leads to reduced lysyl oxidase expression, impaired elastogenesis, and aneurysm

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12 December 2020

Fibronectins in vascular morphogenesis

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12 December 2020

Aortic arch morphogenesis and flow modeling in the chick embryo.

1 reference

12 December 2020

Histology atlas of the developing mouse heart with emphasis on E11.5 to E18.5.

1 reference

12 December 2020

Vascular extracellular matrix and arterial mechanics

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12 December 2020

Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development.

1 reference

12 December 2020

Cellular and molecular mechanisms of thoracic aortic aneurysms

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12 December 2020

The extracellular matrix: not just pretty fibrils

1 reference

12 December 2020

Gene expression profiles in human ruptured and unruptured intracranial aneurysms: what is the role of inflammation?

1 reference

12 December 2020

Sm22α transcription occurs at the early onset of the cardiovascular system and the intron 1 is dispensable for its transcription in smooth muscle cells during mouse development.

1 reference

12 December 2020

Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development

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12 December 2020

Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest

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12 December 2020

TGF-β signaling in aortic aneurysm: another round of controversy.

1 reference

12 December 2020

Focal adhesion kinase regulates smooth muscle cell recruitment to the developing vasculature

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12 December 2020

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane

1 reference

12 December 2020

An essential requirement for β1 integrin in the assembly of extracellular matrix proteins within the vascular wall

1 reference

12 December 2020

Specificity of latent TGF-β binding protein (LTBP) incorporation into matrix: role of fibrillins and fibronectin

1 reference

12 December 2020

The neural crest in cardiac congenital anomalies

1 reference

12 December 2020

Matrix control of transforming growth factor-β function

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12 December 2020

Paxillin regulates pulmonary arterial smooth muscle cell function in pulmonary hypertension

1 reference

12 December 2020

Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway

1 reference

12 December 2020

Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis

1 reference

12 December 2020

The 22q11 deletion: DiGeorge and velocardiofacial syndromes and the role of TBX1.

1 reference

12 December 2020

Smad2 and myocardin-related transcription factor B cooperatively regulate vascular smooth muscle differentiation from neural crest cells

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12 December 2020

Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation

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12 December 2020

Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall

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12 December 2020

Plasma fibronectin promotes modulation of arterial smooth-muscle cells from contractile to synthetic phenotype

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12 December 2020

Neural crest cells contribute to normal aorticopulmonary septation

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12 December 2020

Embryonic mesodermal defects in alpha 5 integrin-deficient mice

1 reference

12 December 2020

Specific roles of the alpha V beta 1, alpha V beta 3 and alpha V beta 5 integrins in avian neural crest cell adhesion and migration on vitronectin

1 reference

12 December 2020

The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro

1 reference

12 December 2020

CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium

1 reference

12 December 2020

Neural crest and cardiovascular patterning.

1 reference

12 December 2020

Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin

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12 December 2020

Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ.

1 reference

12 December 2020

Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins

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12 December 2020

Integrin-mediated reduction in vascular smooth muscle [Ca2+]i induced by RGD-containing peptide

1 reference

12 December 2020

Potential roles of osteopontin and α V β 3 integrin in the development of coronary artery restenosis after angioplasty

1 reference

12 December 2020

Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells.

1 reference

12 December 2020

Neural crest cell contribution to the developing circulatory system: implications for vascular morphology?

1 reference

12 December 2020

Vitronectin regulates smooth muscle contractility via alphav and beta1 integrin

1 reference

12 December 2020

Interactions between growth factors and integrins: latent forms of transforming growth factor-beta are ligands for the integrin alphavbeta1

1 reference

12 December 2020

Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all alpha v integrins

1 reference

12 December 2020

Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase

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12 December 2020

Generalized lacZ expression with the ROSA26 Cre reporter strain

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12 December 2020

Identifiers

DOI

10.1242/DEV.117572

1 reference

30 June 2019

PMC publication ID

6514387

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30 June 2019

PubMed publication ID

25670798

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30 June 2019