(Q53620970)

16 May 2018

title

Bcl-2 family and the central nervous system: from rheostat to real complex. (English)

1 reference

16 May 2018

author

Kevin A. Roth

series ordinal

2

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16 May 2018

author name string

Shacka JJ

series ordinal

1

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16 May 2018

publication date

26 May 2006

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16 May 2018

Cell Death & Differentiation

published in

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16 May 2018

volume

13

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16 May 2018

issue

8

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16 May 2018

page(s)

1299-1304

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16 May 2018

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401974

exact match

0 references

cites work

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

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Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications

21 January 2018

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Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development

21 January 2018

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

21 January 2018

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bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death

21 January 2018

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Differential expression of bcl-w and bcl-x messenger RNA in the developing and adult rat nervous system

21 January 2018

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Tissue expression and subcellular localization of the pro-survival molecule Bcl-w

21 January 2018

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MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

21 January 2018

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21 January 2018

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Signaling of Cell Death and Cell Survival Following Focal Cerebral Ischemia: Life and Death Struggle in the Penumbra

21 January 2018

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Microarray analysis of selected genes in neural stem and progenitor cells.

21 January 2018

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Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

21 January 2018

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Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Caspase regulation of genotoxin-induced neural precursor cell death

21 January 2018

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BH3-only proteins: key regulators of neuronal apoptosis

21 January 2018

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 January 2018

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BID: a novel BH3 domain-only death agonist

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

21 January 2018

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PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

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Direct addition of BimL to mitochondria does not lead to cytochrome c release

21 January 2018

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Brain ischemia/reperfusion-induced expression of DP5 and its interaction with Bcl-2, thus freeing Bax from Bcl-2/Bax dimmers are mediated by c-Jun N-terminal kinase (JNK) pathway

21 January 2018

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Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis

21 January 2018

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BAD is a pro-survival factor prior to activation of its pro-apoptotic function

21 January 2018

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Differential expression of rat brain bcl-2 family proteins in development and aging

21 January 2018

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BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis

21 January 2018

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Bid regulation of neuronal apoptosis

21 January 2018

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

21 January 2018

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

21 January 2018

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The proapoptotic BH3-only protein bim is expressed in hematopoietic, epithelial, neuronal, and germ cells

21 January 2018

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Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

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BNips: a group of pro-apoptotic proteins in the Bcl-2 family

21 January 2018

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Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus

21 January 2018

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Expression pattern of a novel death-promoting gene, DP5, in the developing murine nervous system.

21 January 2018

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p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Noxa is a critical mediator of p53-dependent motor neuron death after nerve injury in adult mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Neural precursor cells possess multiple p53-dependent apoptotic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Molecular chaperone targeting and regulation by BAG family proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Interaction of BAG1 and Hsp70 mediates neuroprotectivity and increases chaperone activity

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Immunohistochemical localization of Bis protein in the rat central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Reactive astrocytes express bis, a bcl-2-binding protein, after transient forebrain ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Autophagy as a cell death and tumor suppressor mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Closed head injury induces upregulation of Beclin 1 at the cortical site of injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Expression of the protooncogene bcl-2 in Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Beta-amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Up-regulation of Bcl-xL in response to subtoxic beta-amyloid: role in neuronal resistance against apoptotic and oxidative injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Apoptosis in amyotrophic lateral sclerosis: a review of the evidence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Expression pattern of apoptosis-related markers in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Sequential activation of individual caspases, and of alterations in Bcl‐2 proapoptotic signals in a mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Modulation of apoptotic regulatory proteins and early activation of cytochrome C following systemic 3-nitropropionic acid administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

6-Hydroxydopamine increases the level of TNFalpha and bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemiparkinsonian rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Puma and p53 play required roles in death evoked in a cellular model of Parkinson disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Prospects for antiapoptotic drug therapy of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

BAG5 inhibits parkin and enhances dopaminergic neuron degeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

The c-Jun N-terminal protein kinase signaling pathway mediates Bax activation and subsequent neuronal apoptosis through interaction with Bim after transient focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Upregulation of the pro-apoptotic BH3-only peptide harakiri in spinal neurons of amyotrophic lateral sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

7 January 2021

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

7 January 2021

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

7 January 2021

Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

7 January 2021

Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

7 January 2021

Amyloid beta peptide of Alzheimer's disease downregulates Bcl-2 and upregulates bax expression in human neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

7 January 2021

Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401974

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401974

1 reference

16 May 2018

1 reference

16 May 2018