(Q54179268)

English

Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes.

scientific article published on 25 December 2014

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26 February 2020

Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes (English)

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26 February 2020

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Maria Palianopoulou

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26 February 2020

author name string

Vassilis Papanikolaou

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26 February 2020

Nikolaos Stefanou

2

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26 February 2020

Stephanie Dubos

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26 February 2020

Ioanna Papathanasiou

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26 February 2020

Vaia Valiakou

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26 February 2020

Aspasia Tsezou

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26 February 2020

publication date

25 December 2014

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26 February 2020

Cellular Oncology

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26 February 2020

38

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26 February 2020

2

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26 February 2020

155-164

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26 February 2020

https://scigraph.springernature.com/pub.10.1007/s13402-014-0213-5

0 references

ABC of breast diseases. Breast cancer-epidemiology, risk factors, and genetics

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Impact of SOX18 expression in cancer cells and vessels on the outcome of invasive ductal breast carcinoma.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Breast cancer incidence and mortality trends in 16 European countries.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Predicting prognosis using molecular profiling in estrogen receptor-positive breast cancer treated with tamoxifen

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

ERM/Rho protein expression in ductal breast cancer: a 15 year follow-up.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Prognostic and predictive value of copy number alterations in invasive breast cancer as determined by multiplex ligation-dependent probe amplification.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Is leptin a mediator of adverse prognostic effects of obesity in breast cancer?

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin--from regulation of fat metabolism to stimulation of breast cancer growth.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Overweight, Obesity, and Mortality from Cancer in a Prospectively Studied Cohort of U.S. Adults

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Positional cloning of the mouse obese gene and its human homologue

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Adipose tissue as an endocrine organ

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Adipocytokines and metabolic syndrome

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Intracellular signalling pathways activated by leptin

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin--much more than a satiety signal

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin in pregnancy

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin: structure, function and biology

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Identification and expression cloning of a leptin receptor, OB-R

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin--a growth factor in normal and malignant breast cells and for normal mammary gland development

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin signaling in breast cancer: An overview

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Presence of leptin in breast cell lines and breast tumors

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Divergent signaling capacities of the long and short isoforms of the leptin receptor

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

STATs and gene regulation

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Stats: transcriptional control and biological impact

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Stat3 promotes metastatic progression of prostate cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Signal transducers and activators of transcription 3 pathway activation in drug-resistant ovarian cancer

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Molecular approaches towards the inhibition of the signal transducer and activator of transcription 3 (Stat3) protein

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Tamoxifen for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin attenuates the anti-estrogen effect of tamoxifen in breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Central obesity and breast cancer risk: a systematic review.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC).

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Longitudinal study on the role of body size in premenopausal breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Serum immunoreactive-leptin concentrations in normal-weight and obese humans

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin Enhances, via AP-1, Expression of Aromatase in the MCF-7 Cell Line

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Chronic leptin treatment sensitizes MCF-7 breast cancer cells to estrogen

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Neoadjuvant treatment of postmenopausal breast cancer with anastrozole, tamoxifen, or both in combination: the Immediate Preoperative Anastrozole, Tamoxifen, or Combined with Tamoxifen (IMPACT) multicenter double-blind randomized trial

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Validating survivin as a cancer therapeutic target

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Concordant loss of fragile gene expression early in breast cancer development

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Physical association with WWOX suppresses c-Jun transcriptional activity

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Deubiquitinase USP9x confers radioresistance through stabilization of Mcl-1

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Survivin regulation by HER2 through NF-κB and c-myc in irradiated breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

Role of leptin in fat regulation

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0213-5

21 January 2018

WW domain-containing oxidoreductase: a candidate tumor suppressor

1 reference

https://pubmed.ncbi.nlm.nih.gov/25539992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

c-erb B2 overexpression decreases the benefit of adjuvant tamoxifen in early-stage breast cancer without axillary lymph node metastases

1 reference

https://pubmed.ncbi.nlm.nih.gov/25539992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Adverse effects of obesity on breast cancer prognosis, and the biological actions of leptin (review).

1 reference

https://pubmed.ncbi.nlm.nih.gov/25539992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulation of Bcl-2 and sensitization to cyt

1 reference

https://pubmed.ncbi.nlm.nih.gov/25539992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

WWOX, the FRA16D gene, behaves as a suppressor of tumor growth

1 reference

https://pubmed.ncbi.nlm.nih.gov/25539992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25539992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Validation of DNA promoter hypermethylation biomarkers in breast cancer — a short report

1 reference

https://pubmed.ncbi.nlm.nih.gov/25539992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25539992

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S13402-014-0213-5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25539992%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25539992%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

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