(Q54182306)

English

A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine.

scientific article published in January 1995

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

A yeast type II topoisomerase selected for resistance to quinolones. Mutation of histidine 1012 to tyrosine confers resistance to nonintercalative drugs but hypersensitivity to ellipticine. (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

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1 reference

Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

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Osheroff N

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Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

author name string

Elsea SH

1

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Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

Hsiung Y

2

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26 May 2018

http://europepmc.org/abstract/MED/7829529

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publication date

1 January 1995

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PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

270

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26 May 2018

http://europepmc.org/abstract/MED/7829529

4

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Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

1913-1920

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Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

Biochemical basis for the interactions of type I and type II topoisomerases with DNA.

1 reference

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Catalytic function of DNA topoisomerase II.

1 reference

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DNA topoisomerase I and II in cancer chemotherapy: update and perspectives

1 reference

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DNA topoisomerases: essential enzymes and lethal targets

1 reference

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When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs

1 reference

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21 January 2018

In vivo mapping of DNA topoisomerase II-specific cleavage sites on SV40 chromatin.

1 reference

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21 January 2018

Protein-associated deoxyribonucleic acid strand breaks in L1210 cells treated with the deoxyribonucleic acid intercalating agents 4'-(9-acridinylamino) methanesulfon-m-anisidide and adriamycin

1 reference

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21 January 2018

Effects of antineoplastic drugs on the post-strand-passage DNA cleavage/religation equilibrium of topoisomerase II.

1 reference

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21 January 2018

Stabilization of the topoisomerase II-DNA cleavage complex by antineoplastic drugs: inhibition of enzyme-mediated DNA religation by 4'-(9-acridinylamino)methanesulfon-m-anisidide.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

Effect of antineoplastic agents on the DNA cleavage/religation reaction of eukaryotic topoisomerase II: inhibition of DNA religation by etoposide.

1 reference

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21 January 2018

Mode of action of topoisomerase II-targeting agents at a specific DNA sequence. Uncoupling the DNA binding, cleavage and religation events

1 reference

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21 January 2018

Effects of novel fluoroquinolones on the catalytic activities of eukaryotic topoisomerase II: Influence of the C-8 fluorine group

1 reference

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21 January 2018

A pyrimido[1,6-a]benzimidazole that enhances DNA cleavage mediated by eukaryotic topoisomerase II: a novel class of topoisomerase II-targeted drugs with cytotoxic potential

1 reference

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21 January 2018

Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide

1 reference

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21 January 2018

Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

Novel selection and genetic characterisation of an etoposide-resistant human leukaemic CCRF-CEM cell line

1 reference

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21 January 2018

Effects of topoisomerase II-targeted drugs on enzyme-mediated DNA cleavage and ATP hydrolysis: evidence for distinct drug interaction domains on topoisomerase II.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

DNA topoisomerase-targeting antitumor drugs can be studied in yeast

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

Recovery of plasmids from yeast into Escherichia coli: shuttle vectors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

DNA sequencing with chain-terminating inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

Calcium-promoted DNA cleavage by eukaryotic topoisomerase II: trapping the covalent enzyme-DNA complex in an active form.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

In vitro mutagenesis and plasmid shuffling: from cloned gene to mutant yeast

1 reference

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21 January 2018

DNA Modification and Cancer

1 reference

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21 January 2018

Drug features that contribute to the activity of quinolones against mammalian topoisomerase II and cultured cells: correlation between enhancement of enzyme-mediated DNA cleavage in vitro and cytotoxic potential

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

The C-terminal domain of Saccharomyces cerevisiae DNA topoisomerase II.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

Functional dissection of the phosphorylated termini of fission yeast DNA topoisomerase II

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

Fluoroquinolone antimicrobial agents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

The molecular basis of quinolone action

1 reference

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21 January 2018

DNA gyrase: structure and function.

1 reference

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21 January 2018

Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II.

1 reference

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21 January 2018

Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

1 reference

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21 January 2018

Mutational alteration of the breakage/resealing subunit of bacteriophage T4 DNA topoisomerase confers resistance to antitumor agent m-AMSA.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

DNA topoisomerases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.270.4.1913

21 January 2018

Effects of the DNA intercalators 4'-(9-acridinylamino)methanesulfon-m-anisidide and 2-methyl-9-hydroxyellipticinium on topoisomerase II mediated DNA strand cleavage and strand passage

1 reference

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21 January 2018

Inhibition of protein synthesis reduces the cytotoxicity of 4'-(9-acridinylamino)methanesulfon-m-anisidide without affecting DNA breakage and DNA topoisomerase II in a murine mastocytoma cell line

1 reference

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21 January 2018

Leucine zipper in human DNA topoisomerase II

1 reference

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21 January 2018

Identifiers

10.1074/JBC.270.4.1913

1 reference

Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

26 May 2018

http://europepmc.org/abstract/MED/7829529

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