(Q54321696)

English

Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells.

scientific article published on 17 September 2014

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

Gefitinib induces cytoplasmic translocation of the CDK inhibitor p27 and its binding to a cleaved intermediate of caspase 8 in non-small cell lung cancer cells. (English)

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

author name string

Sun Hee Ahn

1

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

Eun-Hui Jeong

2

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

Tae-Gul Lee

3

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

Seo Yun Kim

4

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

Hye-Ryoun Kim

5

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

Cheol Hyeon Kim

6

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

publication date

17 September 2014

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

Cellular Oncology

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

37

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

5

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

377-386

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

https://scigraph.springernature.com/pub.10.1007/s13402-014-0198-0

0 references

Epidermal growth factor receptor mutations, small-molecule kinase inhibitors, and non-small-cell lung cancer: current knowledge and future directions

1 reference

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21 January 2018

Insulin-like growth factor-1 receptor (IGF-1R) as a biomarker for resistance to the tyrosine kinase inhibitor gefitinib in non-small cell lung cancer

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Treatment of non-small-cell lung cancer with erlotinib or gefitinib

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

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21 January 2018

Somatic EGFR mutations and efficacy of tyrosine kinase inhibitors in NSCLC.

1 reference

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21 January 2018

Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes

1 reference

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21 January 2018

Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Targeting the cell cycle: a new approach to cancer therapy

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Gefitinib ('Iressa', ZD1839), an epidermal growth factor receptor tyrosine kinase inhibitor, up-regulates p27KIP1 and induces G1 arrest in oral squamous cell carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Caspases: enemies within

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cells

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Induction of cell cycle arrest and apoptosis in human prostate carcinoma cells by a recombinant adenovirus expressing p27(Kip1).

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Overexpression of p27(Kip1) induces growth arrest and apoptosis in an oral cancer cell line

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Erlotinib, an effective epidermal growth factor receptor tyrosine kinase inhibitor, induces p27KIP1 up-regulation and nuclear translocation in association with cell growth inhibition and G1/S phase arrest in human non-small-cell lung cancer cell lin

1 reference

https://api.crossref.org/works/10.1007%2FS13402-014-0198-0

21 January 2018

Promoting apoptosis: a novel activity associated with the cyclin-dependent kinase inhibitor p27

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of the expression of cyclin-dependent kinase inhibitor p27Kip1 and apoptosis in tumor cells on the overall survival of patients with non-early stage gastric carcinoma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced expression and altered subcellular localization of the cyclin-dependent kinase inhibitor p27(Kip1) in human colon cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss or altered subcellular localization of p27 in Barrett's associated adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent loss of expression of the cyclin-dependent kinase inhibitor p27(Kip1) in estrogen-related Endometrial adenocarcinomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lung cancer stem cells: a biological and clinical perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-transduction of p27Kip1 strongly augments Fas ligand- and caspase-8-mediated apoptosis in U-373MG glioma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ZD1839 (Iressa): an orally active inhibitor of epidermal growth factor signaling with potential for cancer therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Frequent loss of expression of the cyclin-dependent kinase inhibitor p27 in epithelial ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Over-expression of p27kip1 induces growth arrest and apoptosis mediated by changes of pRb expression in lung cancer cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/25228008

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S13402-014-0198-0

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 May 2018

http://europepmc.org/abstract/MED/25228008

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