(Q54350035)

28 May 2018

title

Muscle-specific kinase (MuSK) autoantibodies suppress the MuSK pathway and ACh receptor retention at the mouse neuromuscular junction. (English)

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28 May 2018

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neuromuscular junction

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Marco Morsch

2

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William Daniel Phillips

object named as

William D Phillips

5

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author name string

Nazanin Ghazanfari

1

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28 May 2018

Stephen W Reddel

3

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28 May 2018

Simon X Liang

4

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28 May 2018

language of work or name

English

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publication date

23 May 2014

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28 May 2018

published in

Journal of Physiology

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28 May 2018

volume

592

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28 May 2018

issue

13

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28 May 2018

page(s)

2881-2897

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28 May 2018

Neurotransmitter receptor dynamics studied in vivo by reversible photo-unbinding of fluorescent ligands

cites work

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Interactions of the rapsyn RING-H2 domain with dystroglycan

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

The zinc finger domain of the 43-kDa receptor-associated protein, rapsyn: role in acetylcholine receptor clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Structure and regulation of Src family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Identification of a motif in the acetylcholine receptor beta subunit whose phosphorylation regulates rapsyn association and postsynaptic receptor localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Identification of nicotinic acetylcholine receptor recycling and its role in maintaining receptor density at the neuromuscular junction in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

The dynamics of recycled acetylcholine receptors at the neuromuscular junction in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Sequence of age-associated changes to the mouse neuromuscular junction and the protective effects of voluntary exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Rapsyn mediates subsynaptic anchoring of PKA type I and stabilisation of acetylcholine receptor in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Regulation of nicotinic receptor expression by the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Patient autoantibodies deplete postsynaptic muscle-specific kinase leading to disassembly of the ACh receptor scaffold and myasthenia gravis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Anti-MuSK patient antibodies disrupt the mouse neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Synaptic differentiation is defective in mice lacking acetylcholine receptor beta-subunit tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Functional interaction of Src family kinases with the acetylcholine receptor in C2 myotubes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Developmental increase in the amount of rapsyn per acetylcholine receptor promotes postsynaptic receptor packing and stability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Increased ratio of rapsyn to ACh receptor stabilizes postsynaptic receptors at the mouse neuromuscular synapse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Agrin acts via a MuSK receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Maturation and maintenance of the neuromuscular synapse: genetic evidence for roles of the dystrophin--glycoprotein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Autoantibodies to low-density lipoprotein receptor-related protein 4 in myasthenia gravis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Rapsyn-mediated clustering of acetylcholine receptor subunits requires the major cytoplasmic loop of the receptor subunits

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

MuSK IgG4 autoantibodies cause myasthenia gravis by inhibiting binding between MuSK and Lrp4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Degradation of acetylcholine receptors in muscle cells: effect of leupeptin on turnover rate, intracellular pool sizes, and receptor properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

The dystroglycan complex is necessary for stabilization of acetylcholine receptor clusters at neuromuscular junctions and formation of the synaptic basement membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Anti-MuSK autoantibodies block binding of collagen Q to MuSK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

MuSK controls where motor axons grow and form synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Lrp4 is a receptor for Agrin and forms a complex with MuSK

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Muscle-specific kinase myasthenia gravis IgG4 autoantibodies cause severe neuromuscular junction dysfunction in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

MuSK myasthenia gravis IgG4 disrupts the interaction of LRP4 with MuSK but both IgG4 and IgG1-3 can disperse preformed agrin-independent AChR clusters

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Rapsyn interacts with the muscle acetylcholine receptor via alpha-helical domains in the alpha, beta, and epsilon subunit intracellular loops

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Differential requirement for MuSK and dystroglycan in generating patterns of neuromuscular innervation

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Increased expression of rapsyn in muscles prevents acetylcholine receptor loss in experimental autoimmune myasthenia gravis

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Detection and characterization of MuSK antibodies in seronegative myasthenia gravis

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

The influence of basal lamina on the accumulation of acetylcholine receptors at synaptic sites in regenerating muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

A single pulse of agrin triggers a pathway that acts to cluster acetylcholine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Agrin regulates rapsyn interaction with surface acetylcholine receptors, and this underlies cytoskeletal anchoring and clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Antibodies against muscle-specific kinase impair both presynaptic and postsynaptic functions in a murine model of myasthenia gravis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Divalent and monovalent autoantibodies cause dysfunction of MuSK by distinct mechanisms in a rabbit model of myasthenia gravis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Pyridostigmine but not 3,4-diaminopyridine exacerbates ACh receptor loss and myasthenia induced in mice by muscle-specific kinase autoantibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Neuregulin-1 potentiates agrin-induced acetylcholine receptor clustering through muscle-specific kinase phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Pre- and postsynaptic neuromuscular junction abnormalities in musk myasthenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Clinical and experimental features of MuSK antibody positive MG in Japan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Association of the postsynaptic 43K protein with newly formed acetylcholine receptor clusters in cultured muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Clustering and immobilization of acetylcholine receptors by the 43-kD protein: a possible role for dystrophin-related protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

The roles of the dystrophin-associated glycoprotein complex at the synapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Disruption and reformation of the acetylcholine receptor clusters of cultured rat myotubes occur in two distinct stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Muscle-selective synaptic disassembly and reorganization in MuSK antibody positive MG mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Role of rapsyn tetratricopeptide repeat and coiled-coil domains in self-association and nicotinic acetylcholine receptor clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Myosin Va cooperates with PKA RIalpha to mediate maintenance of the endplate in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Src-family kinases stabilize the neuromuscular synapse in vivo via protein interactions, phosphorylation, and cytoskeletal linkage of acetylcholine receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Neuregulin/ErbB regulate neuromuscular junction development by phosphorylation of α-dystrobrevin

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Are MuSK antibodies the primary cause of myasthenic symptoms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Induction of myasthenia by immunization against muscle-specific kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Acetylcholine receptors loss and postsynaptic damage in MuSK antibody-positive myasthenia gravis

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Split tolerance in a novel transgenic model of autoimmune myasthenia gravis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Laminin-induced acetylcholine receptor clustering: an alternative pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Passive and active immunization models of MuSK-Ab positive myasthenia: electrophysiological evidence for pre and postsynaptic defects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Cooperative regulation by Rac and Rho of agrin-induced acetylcholine receptor clustering in muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

LRP4 serves as a coreceptor of agrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Structure and superorganization of acetylcholine receptor-rapsyn complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Collagen Q is a key player for developing rational therapy for congenital myasthenia and for dissecting the mechanisms of anti-MuSK myasthenia gravis

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221826

Acute severe animal model of anti-muscle-specific kinase myasthenia: combined postsynaptic and presynaptic changes

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221826

Anti-LRP4 autoantibodies in AChR- and MuSK-antibody-negative myasthenia gravis

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221826

A role for the juxtamembrane domain of beta-dystroglycan in agrin-induced acetylcholine receptor clustering.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221826

Src-class kinases act within the agrin/MuSK pathway to regulate acetylcholine receptor phosphorylation, cytoskeletal anchoring, and clustering.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221826

Agrin-induced activation of acetylcholine receptor-bound Src family kinases requires Rapsyn and correlates with acetylcholine receptor clustering.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221826

Roles of rapsyn and agrin in interaction of postsynaptic proteins with acetylcholine receptors.

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4221826

Reporting ethical matters in the Journal of Physiology: standards and advice

2 November 2018

1 reference

https://api.crossref.org/works/10.1113%2FJPHYSIOL.2013.270207

Muscle specific kinase autoantibodies cause synaptic failure through progressive wastage of postsynaptic acetylcholine receptors

21 January 2018

1 reference

12 December 2020

Laminin and alpha-dystroglycan mediate acetylcholine receptor aggregation via a MuSK-independent pathway

1 reference

12 December 2020

Dimerization of the muscle-specific kinase induces tyrosine phosphorylation of acetylcholine receptors and their aggregation on the surface of myotubes

1 reference

12 December 2020

Evidence for in situ and in vitro association between beta-dystroglycan and the subsynaptic 43K rapsyn protein. Consequence for acetylcholine receptor clustering at the synapse

1 reference

12 December 2020

In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor

1 reference

12 December 2020

Rapid and reversible effects of activity on acetylcholine receptor density at the neuromuscular junction in vivo

1 reference

12 December 2020

Myasthenia gravis. Study of humoral immune mechanisms by passive transfer to mice

1 reference

12 December 2020

10.1113/JPHYSIOL.2013.270207

Identifiers

DOI

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28 May 2018

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28 May 2018