(Q54428424)

English

Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes.

scientific article published on 12 May 2010

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

Ajoene, a stable garlic by-product, has an antioxidant effect through Nrf2-mediated glutamate-cysteine ligase induction in HepG2 cells and primary hepatocytes. (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

1 reference

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inferred from title

7

object named as

Raok Jeon

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

author name string

Hee Yeon Kay

1

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

Jin Won Yang

2

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

Tae Hyun Kim

3

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

Da Yeon Lee

4

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

Bomi Kang

5

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

Jae-Ha Ryu

6

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

Sang Geon Kim

8

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

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publication date

12 May 2010

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

Journal of Nutrition

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

140

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

7

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Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

1211-1219

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

Cancer chemoprevention with garlic and its constituents

1 reference

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Composition, stability, and bioavailability of garlic products used in a clinical trial

1 reference

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21 January 2018

The chemistry of garlic and onions

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The Organosulfur Chemistry of the GenusAllium - Implications for the Organic Chemistry of Sulfur

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Ajoene inhibits both primary tumor growth and metastasis of B16/BL6 melanoma cells in C57BL/6 mice

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Glutathione and its role in cellular functions

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21 January 2018

Gender difference in glutathione metabolism during aging in mice

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Evidence for functionally significant polymorphism of human glutamate cysteine ligase catalytic subunit: association with glutathione levels and drug resistance in the National Cancer Institute tumor cell line panel

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Cellular glutathione and thiols metabolism.

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

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21 January 2018

Regulatory mechanisms controlling gene expression mediated by the antioxidant response element

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High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes

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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

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Glucocorticoid receptor (GR)-associated SMRT binding to C/EBPbeta TAD and Nrf2 Neh4/5: role of SMRT recruited to GR in GSTA2 gene repression

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21 January 2018

Identification of a novel class of dithiolethiones that prevent hepatic insulin resistance via the adenosine monophosphate-activated protein kinase-p70 ribosomal S6 kinase-1 pathway

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21 January 2018

Overlapping antioxidant response element and PMA response element sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene

1 reference

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21 January 2018

Keap1 regulates both cytoplasmic-nuclear shuttling and degradation of Nrf2 in response to electrophiles

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21 January 2018

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21 January 2018

Resveratrol induces glutathione synthesis by activation of Nrf2 and protects against cigarette smoke-mediated oxidative stress in human lung epithelial cells

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21 January 2018

Efficacy of sauchinone as a novel AMPK-activating lignan for preventing iron-induced oxidative stress and liver injury.

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21 January 2018

Resveratrol protects mitochondria against oxidative stress through AMP-activated protein kinase-mediated glycogen synthase kinase-3beta inhibition downstream of poly(ADP-ribose)polymerase-LKB1 pathway

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21 January 2018

Inhibition of arachidonic acid and iron-induced mitochondrial dysfunction and apoptosis by oltipraz and novel 1,2-dithiole-3-thione congeners

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21 January 2018

Enhancement of ajoene-induced apoptosis by conjugated linoleic acid in 3T3-L1 adipocytes

1 reference

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21 January 2018

The cytotoxic effect of ajoene, a natural product from garlic, investigated with different cell lines

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21 January 2018

Scaffolding of Keap1 to the actin cytoskeleton controls the function of Nrf2 as key regulator of cytoprotective phase 2 genes

1 reference

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21 January 2018

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression

1 reference

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21 January 2018

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

1 reference

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21 January 2018

Up-regulation of the human gamma-glutamylcysteine synthetase regulatory subunit gene involves binding of Nrf-2 to an electrophile responsive element

1 reference

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21 January 2018

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

1 reference

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21 January 2018

Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals

1 reference

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21 January 2018

Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy subunit gene is regulated by a distal antioxidant response element/TRE sequence

1 reference

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Tumour necrosis factor alpha induces co-ordinated activation of rat GSH synthetic enzymes via nuclear factor kappaB and activator protein-1

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Inhibition of ERK and p38 MAP kinases inhibits binding of Nrf2 and induction of GCS genes

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Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription

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Rottlerin, a novel protein kinase inhibitor

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The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection.

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Protein oxidation and aging

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Mitochondrial disease in mouse results in increased oxidative stress

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Hepatocyte-specific deletion of the keap1 gene activates Nrf2 and confers potent resistance against acute drug toxicity.

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Inhibition of whole blood platelet-aggregation by compounds in garlic clove extracts and commercial garlic products

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Identifiers

10.3945/JN.110.121277

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 May 2018

http://europepmc.org/abstract/MED/20463144

ResearchGate publication ID

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