(Q54453884)

30 May 2018

title

Cystathionase mediates senescence evasion in melanocytes and melanoma cells. (English)

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30 May 2018

author

Martin Eilers

7

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30 May 2018

Manfred Schartl

8

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30 May 2018

author name string

C Leikam

1

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30 May 2018

A Hufnagel

2

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30 May 2018

S Walz

3

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30 May 2018

S Kneitz

4

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30 May 2018

A Fekete

5

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30 May 2018

M J Müller

6

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30 May 2018

S Meierjohann

9

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30 May 2018

language of work or name

English

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publication date

28 January 2013

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30 May 2018

published in

Oncogene

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30 May 2018

volume

33

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30 May 2018

issue

6

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30 May 2018

page(s)

771-782

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30 May 2018

Oncogenic mutations in GNAQ occur early in uveal melanoma

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The relation between c-myc expression and interferon sensitivity in uveal melanoma.

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Myc down-regulation sensitizes melanoma cells to radiotherapy by inhibiting MLH1 and MSH2 mismatch repair proteins

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C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells

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Myc down-regulation as a mechanism to activate the Rb pathway in STAT5A-induced senescence.

21 January 2018

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Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1

21 January 2018

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Negative regulation of the mammalian UV response by Myc through association with Miz-1

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Repression of p15INK4b expression by Myc through association with Miz-1

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Transcriptional repression by Myc.

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From Mendelian to molecular genetics: the Xiphophorus melanoma model

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Dual regulation of proliferation and apoptosis: c-myc in bitransgenic murine mammary tumor models

21 January 2018

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Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

21 January 2018

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Ubiquitylation of the amino terminus of Myc by SCF(β-TrCP) antagonizes SCF(Fbw7)-mediated turnover

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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

21 January 2018

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Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage

21 January 2018

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The role of cystathionine beta-synthase in homocysteine metabolism

21 January 2018

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The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond

21 January 2018

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Structural basis for the inhibition mechanism of human cystathionine gamma-lyase, an enzyme responsible for the production of H(2)S

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Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway.

21 January 2018

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Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism

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The reactive oxygen-driven tumor: relevance to melanoma

21 January 2018

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Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells

21 January 2018

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Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis

21 January 2018

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Deconstructing PML-induced premature senescence

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.641

Enhanced elimination of oxidized guanine nucleotides inhibits oncogenic RAS-induced DNA damage and premature senescence

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.641

TC1 (C8orf4) is upregulated by cellular stress and mediates heat shock response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

FoxM1c counteracts oxidative stress-induced senescence and stimulates Bmi-1 expression.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.641

C-Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.641

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

21 January 2018

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

21 January 2018

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c-Myc-induced aberrant DNA synthesis and activation of DNA damage response in p300 knockdown cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2012.641

c-Myc accelerates S-phase and requires WRN to avoid replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Werner syndrome protein limits MYC-induced cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Inhibition of c-Myc oncoprotein limits the growth of human melanoma cells by inducing cellular crisis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

c-Myc phosphorylation is required for cellular response to oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Gamma-glutamylcysteine synthetase mediates the c-Myc-dependent response to antineoplastic agents in melanoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

The interaction between Myc and Miz1 is required to antagonize TGFbeta-dependent autocrine signaling during lymphoma formation and maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

The cystine/cysteine cycle and GSH are independent and crucial antioxidant systems in malignant melanoma cells and represent druggable targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Importance of the trans-sulfuration pathway in cancer prevention and promotion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Glutathione depletion causes a JNK and p38MAPK-mediated increase in expression of cystathionine-gamma-lyase and upregulation of the transsulfuration pathway in C6 glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Butyrate-stimulated H2S production in colon cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Role of ATF4 in regulation of autophagy and resistance to drugs and hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Site-directed mutagenesis on human cystathionine-gamma-lyase reveals insights into the modulation of H2S production

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Hydrogen sulphide and its therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Cellular senescence in naevi and immortalisation in melanoma: a role for p16?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Fbw7 and Usp28 regulate myc protein stability in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

The MK5/PRAK kinase and Myc form a negative feedback loop that is disrupted during colorectal tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

c-Myc down-regulation increases susceptibility to cisplatin through reactive oxygen species-mediated apoptosis in M14 human melanoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Oncogene activation in melanocytes links reactive oxygen to multinucleated phenotype and senescence

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Effect of epidermal growth factor on the expression of protooncogenes c-myc and c-Ha-ras in short-term primary hepatocyte culture

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Role of the transsulfuration pathway and of gamma-cystathionase activity in the formation of cysteine and sulfate from methionine in rat hepatocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Effect of cysteine on expression of cystathionine beta-synthase in the rat liver

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

The oncogenic epidermal growth factor receptor variant Xiphophorus melanoma receptor kinase induces motility in melanocytes by modulation of focal adhesions

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2012.641

31 March 2020

Identifiers

DOI

10.1038/ONC.2012.641

1 reference

30 May 2018

Dimensions Publication ID

1048695125

0 references

1 reference

30 May 2018