(Q39763259)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20010815%20AND%20SRC:MED&resulttype=core&format=json

15 January 2020

title

Cdk2 suppresses cellular senescence induced by the c-myc oncogene (English)

1 reference

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15 January 2020

1 reference

1

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15 January 2020

Mirko Doni

2

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Óscar Fernández-Capetillo

15 January 2020

11

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15 January 2020

Bruno Amati

14

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15 January 2020

7

Thomas Schleker

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15 January 2020

Matilde Murga

10

object named as

Matilde Murga

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15 January 2020

author name string

Per Hydbring

3

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15 January 2020

Alessandro Verrecchia

4

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15 January 2020

Lucia Bianchi

5

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15 January 2020

Domenico Sardella

6

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15 January 2020

Daniele Perna

8

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15 January 2020

Susanna Tronnersjö

9

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15 January 2020

Mariano Barbacid

12

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15 January 2020

Lars-Gunnar Larsson

13

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15 January 2020

publication date

13 December 2009

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15 January 2020

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15 January 2020

volume

12

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15 January 2020

page(s)

54-9; sup pp 1-14

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15 January 2020

issue

1

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https://scigraph.springernature.com/pub.10.1038/ncb2004

15 January 2020

exact match

0 references

cites work

Cellular senescence: when bad things happen to good cells

1 reference

21 January 2018

Myc and the cell cycle

1 reference

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice.

21 January 2018

1 reference

Cdk2 knockout mice are viable

21 January 2018

1 reference

Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

21 January 2018

1 reference

Werner syndrome protein limits MYC-induced cellular senescence

21 January 2018

1 reference

c-Myc accelerates S-phase and requires WRN to avoid replication stress

21 January 2018

1 reference

Cdk1 is sufficient to drive the mammalian cell cycle

21 January 2018

1 reference

Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1).

21 January 2018

1 reference

Cdc2-cyclin E complexes regulate the G1/S phase transition

21 January 2018

1 reference

MYC can enforce cell cycle transit from G1 to S and G2 to S, but not mitotic cellular division, independent of p27-mediated inihibition of cyclin E/CDK2.

21 January 2018

1 reference

Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts

21 January 2018

1 reference

CDK2 is required by MYC to induce apoptosis

21 January 2018

1 reference

Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression.

21 January 2018

1 reference

ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

21 January 2018

1 reference

Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

21 January 2018

1 reference

Non-transcriptional control of DNA replication by c-Myc

21 January 2018

1 reference

c-Myc induces chromosomal rearrangements through telomere and chromosome remodeling in the interphase nucleus

21 January 2018

1 reference

HIF-dependent antitumorigenic effect of antioxidants in vivo

21 January 2018

1 reference

Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers

21 January 2018

1 reference

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

21 January 2018

1 reference

Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation

21 January 2018

1 reference

Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice

21 January 2018

1 reference

Loss of p27(Kip1) but not p21(Cip1) decreases survival and synergizes with MYC in murine lymphomagenesis

21 January 2018

1 reference

Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis

21 January 2018

1 reference

Short telomeres limit tumor progression in vivo by inducing senescence

21 January 2018

1 reference

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence

21 January 2018

1 reference

Proliferation of cancer cells despite CDK2 inhibition.

21 January 2018

1 reference

Identification of CDK2 substrates in human cell lysates

21 January 2018

1 reference

Cyclin-dependent kinases regulate the antiproliferative function of Smads.

21 January 2018

1 reference

Cyclin E and c-Myc promote cell proliferation in the presence of p16INK4a and of hypophosphorylated retinoblastoma family proteins.

21 January 2018

1 reference

Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC.

21 January 2018

1 reference

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

1 reference

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

21 January 2018

1 reference

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

21 January 2018

1 reference

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

21 January 2018

1 reference

CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation

21 January 2018

1 reference

Global chromatin compaction limits the strength of the DNA damage response

21 January 2018

1 reference

Dissecting p53 tumor suppressor functions in vivo

21 January 2018

1 reference

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

1 reference

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

21 January 2018

2 references

21 January 2018

12 December 2020

Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response

1 reference

The Myc-evoked DNA damage response accounts for treatment resistance in primary lymphomas in vivo.

21 January 2018

1 reference

12 December 2020

Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis

1 reference

12 December 2020

Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc

1 reference

12 December 2020

Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

1 reference

12 December 2020

Frequent mutations in the p53 gene in human myeloid leukemia cell lines

1 reference

12 December 2020

MYC can induce DNA breaks in vivo and in vitro independent of reactive oxygen species

1 reference

12 December 2020

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

1 reference

12 December 2020

Posttranslational regulation of Myc function in response to phorbol ester/interferon-gamma-induced differentiation of v-Myc-transformed U-937 monoblasts.

1 reference

12 December 2020

p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.

1 reference

12 December 2020

c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability

1 reference

12 December 2020