(Q54472611)

30 May 2018

title

P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation. (English)

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30 May 2018

author name string

S Zhang

1

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30 May 2018

J Ye

2

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30 May 2018

Y Zhang

3

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30 May 2018

X Xu

4

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30 May 2018

J Liu

5

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30 May 2018

S H Zhang

6

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30 May 2018

S P Kunapuli

7

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30 May 2018

Z Ding

8

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30 May 2018

publication date

1 January 2013

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30 May 2018

Journal of Thrombosis and Haemostasis

published in

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30 May 2018

volume

11

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30 May 2018

issue

1

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30 May 2018

page(s)

149-160

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30 May 2018

Thrombin-triggered platelet apoptosis.

cites work

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Thrombin induces activation and translocation of Bid, Bax and Bak to the mitochondria in human platelets.

21 January 2018

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Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis

21 January 2018

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Mechanisms of resveratrol-induced platelet apoptosis.

21 January 2018

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Thrombin activity and platelet microparticle formation are increased in type 2 diabetic platelets: a potential correlation with caspase activation

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Platelet apoptosis in paediatric immune thrombocytopenia is ameliorated by intravenous immunoglobulin

21 January 2018

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Phosphatidylserine exposure and other apoptotic-like events in Bernard-Soulier syndrome platelets

21 January 2018

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P-selectin-dependent platelet aggregation and apoptosis may explain the decrease in platelet count during Helicobacter pylori infection

21 January 2018

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Thrombocytopenia in an animal model of malaria is associated with an increased caspase-mediated death of thrombocytes

21 January 2018

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The glycoprotein Ibalpha-von Willebrand factor interaction induces platelet apoptosis

21 January 2018

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The GPIIbIIIa antagonist drugs eptifibatide and tirofiban do not induce activation of apoptosis executioner caspase-3 in resting platelets but inhibit caspase-3 activation in platelets stimulated with thrombin or calcium ionophore A23187.

21 January 2018

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Central role of the P2Y12 receptor in platelet activation

21 January 2018

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Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1.

21 January 2018

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Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

21 January 2018

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BF0801, a novel adenine derivative, inhibits platelet activation via phosphodiesterase inhibition and P2Y12 antagonism.

21 January 2018

1 reference

The BH3 mimetic ABT-737 induces cancer cell senescence.

21 January 2018

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BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

21 January 2018

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Anandamide extends platelets survival through CB(1)-dependent Akt signaling

21 January 2018

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Akt Activation in Platelets Depends on Gi Signaling Pathways

21 January 2018

1 reference

Contribution of the P2Y12 receptor-mediated pathway to platelet hyperreactivity in hypercholesterolemia

21 January 2018

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ABT-737, an inhibitor of Bcl-2 family proteins, is a potent inducer of apoptosis in multiple myeloma cells.

21 January 2018

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The phosphoinositide 3-kinase pathway

21 January 2018

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Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival

21 January 2018

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Programmed anuclear cell death delimits platelet life span.

21 January 2018

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BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets

21 January 2018

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Bax dimerizes via a symmetric BH3:groove interface during apoptosis

21 January 2018

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Platelet apoptosis by cold-induced glycoprotein Ibα clustering

21 January 2018

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The role of the intrinsic apoptosis pathway in platelet life and death.

21 January 2018

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Principles of cancer therapy: oncogene and non-oncogene addiction

21 January 2018

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Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors.

21 January 2018

1 reference

Weak platelet agonists and U46619 induce apoptosis-like events in platelets, in the absence of phosphatidylserine exposure

21 January 2018

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Serotonin enhances platelet procoagulant properties and their activation induced during platelet tissue factor uptake.

21 January 2018

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PI3K signalling: the path to discovery and understanding.

21 January 2018

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Phosphoinositide 3-kinase signalling in the vascular system.

21 January 2018

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Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation.

21 January 2018

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Immune cell regulation by autocrine purinergic signalling

21 January 2018

1 reference

Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/JTH.12063

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30 May 2018

PubMed ID

23140172

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30 May 2018