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The BH3 mimetic ABT-737 induces cancer cell senescence.
scientific article published on 16 November 2010
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scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
title
The BH3 mimetic ABT-737 induces cancer cell senescence
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
author
Jin H Song
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
author name string
Karthikeyan Kandasamy
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2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
Marina Zemskova
series ordinal
3
1 reference
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Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
Ying-Wei Lin
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
Andrew S Kraft
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
language of work or name
English
0 references
publication date
16 November 2010
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
published in
Cancer Research
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
volume
71
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
issue
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
page(s)
506-515
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
cites work
p53-dependent induction of prostate cancer cell senescence by the PIM1 protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Identification of expression signatures predictive of sensitivity to the Bcl-2 family member inhibitor ABT-263 in small cell lung carcinoma and leukemia/lymphoma cell lines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Caspase 3/caspase-activated DNase promote cell differentiation by inducing DNA strand breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
DR5-mediated DISC controls caspase-8 cleavage and initiation of apoptosis in human glioblastomas.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Modulation of T lymphocyte replicative senescence via TNF-{alpha} inhibition: role of caspase-3.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
RasV12-mediated down-regulation of CCAAT/enhancer binding protein beta in immortalized fibroblasts requires loss of p19Arf and facilitates bypass of oncogene-induced senescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Chemokine signaling via the CXCR2 receptor reinforces senescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Unexpected pieces to the senescence puzzle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
BH3 mimetic ABT-737 potentiates TRAIL-mediated apoptotic signaling by unsequestering Bim and Bak in human pancreatic cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
BH3 profiling identifies three distinct classes of apoptotic blocks to predict response to ABT-737 and conventional chemotherapeutic agents
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Peroxynitrite induces senescence and apoptosis of red blood cells through the activation of aspartyl and cysteinyl proteases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
The Bcl-2 family: roles in cell survival and oncogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Cellular senescence as a tumor-suppressor mechanism
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Change of the death pathway in senescent human fibroblasts in response to DNA damage is caused by an inability to stabilize p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Effects of p21Waf1/Cip1/Sdi1 on cellular gene expression: implications for carcinogenesis, senescence, and age-related diseases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Cdk2 suppresses cellular senescence induced by the c-myc oncogene.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Apoptosis-based treatment of glioblastomas with ABT-737, a novel small molecule inhibitor of Bcl-2 family proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
ABT-737 induces expression of the death receptor 5 and sensitizes human cancer cells to TRAIL-induced apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Cell cycle arrest and apoptosis provoked by UV radiation-induced DNA damage are transcriptionally highly divergent responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
14 September 2017
Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
25 September 2017
Role of cyclin-dependent kinase inhibitors in the growth arrest at senescence in human prostate epithelial and uroepithelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
25 September 2017
Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
15 June 2018
A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
21 August 2018
Human astrocytes are resistant to Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
21 August 2018
Oncogene-induced senescence as an initial barrier in lymphoma development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
21 August 2018
Senescence-associated cell death of human endothelial cells: the role of oxidative stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3459262
retrieved
21 August 2018
Cytokine loops driving senescence
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21084274
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21084274
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/0008-5472.CAN-10-1977
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
PMC publication ID
3459262
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
PubMed publication ID
21084274
1 reference
stated in
Europe PubMed Central
PMC publication ID
3459262
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21084274%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 January 2020
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