(Q54476060)

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Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression.

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Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23087024

Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression. (English)

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Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23087024

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arterial hypertension

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based on heuristic

inferred from title

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based on heuristic

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Loredana Ciuclan

1

object named as

Loredana Ciuclan

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30 May 2018

http://europepmc.org/abstract/MED/23087024

14

object named as

Gabor Jarai

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30 May 2018

http://europepmc.org/abstract/MED/23087024

Nicholas Duggan

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object named as

Nicholas Duggan

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30 May 2018

http://europepmc.org/abstract/MED/23087024

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Martin J Hussey

2

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30 May 2018

http://europepmc.org/abstract/MED/23087024

Victoria Burton

3

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http://europepmc.org/abstract/MED/23087024

Robert Good

4

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30 May 2018

http://europepmc.org/abstract/MED/23087024

Sarah Beach

6

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http://europepmc.org/abstract/MED/23087024

Peter Jones

7

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http://europepmc.org/abstract/MED/23087024

Roy Fox

8

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http://europepmc.org/abstract/MED/23087024

Ieuan Clay

9

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http://europepmc.org/abstract/MED/23087024

Olivier Bonneau

10

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http://europepmc.org/abstract/MED/23087024

Irena Konstantinova

11

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30 May 2018

http://europepmc.org/abstract/MED/23087024

Andrew Pearce

12

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http://europepmc.org/abstract/MED/23087024

David J Rowlands

13

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http://europepmc.org/abstract/MED/23087024

John Westwick

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http://europepmc.org/abstract/MED/23087024

Margaret R MacLean

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http://europepmc.org/abstract/MED/23087024

Matthew Thomas

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18 October 2012

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http://europepmc.org/abstract/MED/23087024

American Journal of Respiratory and Critical Care Medicine

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http://europepmc.org/abstract/MED/23087024

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http://europepmc.org/abstract/MED/23087024

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1

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http://europepmc.org/abstract/MED/23087024

Cellular and molecular basis of pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Molecular signature of a right heart failure program in chronic severe pulmonary hypertension.

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21 January 2018

Treatment of pulmonary arterial hypertension with targeted therapies

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

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Mechanisms of disease: pulmonary arterial hypertension.

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

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Targeted approaches to the treatment of pulmonary hypertension.

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Evaluation of imatinib mesylate in the treatment of pulmonary arterial hypertension

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Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension

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Imatinib mesylate for the treatment of pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

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PDGF enhances store-operated Ca2+ entry by upregulating STIM1/Orai1 via activation of Akt/mTOR in human pulmonary arterial smooth muscle cells.

1 reference

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21 January 2018

Inflammation, growth factors, and pulmonary vascular remodeling

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Reversal of experimental pulmonary hypertension by PDGF inhibition

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Alterations in Ca2+ cycling by lysoplasmenylcholine in adult rabbit ventricular myocytes

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Structural resemblances and comparisons of the relative pharmacological properties of imatinib and nilotinib

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21 January 2018

Collagen I induces discoidin domain receptor (DDR) 1 expression through DDR2 and a JAK2-ERK1/2-mediated mechanism in primary human lung fibroblasts

1 reference

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21 January 2018

Inhibition of collagen-induced discoidin domain receptor 1 and 2 activation by imatinib, nilotinib and dasatinib

1 reference

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21 January 2018

The serotonin hypothesis of pulmonary hypertension revisited

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Pulmonary hypertension, anorexigens and 5-HT: pharmacological synergism in action?

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Cross talk between endothelial and smooth muscle cells in pulmonary hypertension: critical role for serotonin-induced smooth muscle hyperplasia.

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Effect of Tryptophan Hydroxylase 1 Deficiency on the Development of Hypoxia-Induced Pulmonary Hypertension

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Serotonin transporter interacts with the PDGFβ receptor in PDGF-BB-induced signaling and mitogenesis in pulmonary artery smooth muscle cells

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

The 5-HT transporter transactivates the PDGFbeta receptor in pulmonary artery smooth muscle cells.

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

A novel murine model of severe pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Serotonin secretion by human carcinoid BON cells

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Bone morphogenetic protein receptor II regulates pulmonary artery endothelial cell barrier function

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

MatInspector and beyond: promoter analysis based on transcription factor binding sites

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Imatinib for the treatment of pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy.

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Endothelial cell dysfunction and cross talk between endothelium and smooth muscle cells in pulmonary arterial hypertension.

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Clinical perspective: biomarkers in pulmonary arterial hypertension

1 reference

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21 January 2018

Serotonin and pulmonary hypertension--from bench to bedside?

1 reference

https://api.crossref.org/works/10.1164%2FRCCM.201206-1028OC

21 January 2018

Imatinib mesylate has limited activity against the central nervous system involvement of Philadelphia chromosome-positive acute lymphoblastic leukaemia due to poor penetration into cerebrospinal fluid

1 reference

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21 January 2018

Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans.

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21 January 2018

Clinical and in vitro studies of imatinib in advanced carcinoid tumors

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Overexpression of the 5-hydroxytryptamine transporter gene: effect on pulmonary hemodynamics and hypoxia-induced pulmonary hypertension.

1 reference

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21 January 2018

Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention

1 reference

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21 January 2018

Novel interactions between the 5-HT transporter, 5-HT1B receptors and Rho kinase in vivo and in pulmonary fibroblasts

1 reference

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21 January 2018

Serotonin transporter, sex, and hypoxia: microarray analysis in the pulmonary arteries of mice identifies genes with relevance to human PAH.

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The serotonin transporter, gender, and 17β oestradiol in the development of pulmonary arterial hypertension.

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21 January 2018

Identifiers

10.1164/RCCM.201206-1028OC

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23087024

1 reference

Europe PubMed Central

30 May 2018

http://europepmc.org/abstract/MED/23087024

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