(Q54486386)

30 May 2018

title

Polyploidy road to therapy-induced cellular senescence and escape. (English)

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30 May 2018

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Qin Wang

1

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30 May 2018

Peter C Wu

2

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David Z Dong

3

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Iana Ivanova

4

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Elizabeth Chu

5

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Steven Zeliadt

6

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Hubert Vesselle

7

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Daniel Y Wu

8

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language of work or name

English

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publication date

16 November 2012

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International Journal of Cancer

published in

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volume

132

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issue

7

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page(s)

1505-1515

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p53 and chemosensitivity.

cites work

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Molecular basis for therapy resistance

21 January 2018

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Therapy-induced senescence in cancer

21 January 2018

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Chemopreventive agents induce a senescence-like phenotype in rat mammary tumours

21 January 2018

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Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction

21 January 2018

1 reference

Evasion of a single-step, chemotherapy-induced senescence in breast cancer cells: implications for treatment response

21 January 2018

1 reference

Role of senescence and mitotic catastrophe in cancer therapy

21 January 2018

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Src inhibits adriamycin-induced senescence and G2 checkpoint arrest by blocking the induction of p21waf1.

21 January 2018

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Autophagic cell death, polyploidy and senescence induced in breast tumor cells by the substituted pyrrole JG-03-14, a novel microtubule poison

21 January 2018

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Bleomycin-induced over-replication involves sustained inhibition of mitotic entry through the ATM/ATR pathway.

21 January 2018

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Endopolyploidy in irradiated p53-deficient tumour cell lines: persistence of cell division activity in giant cells expressing Aurora-B kinase

21 January 2018

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Segregation of genomes in polyploid tumour cells following mitotic catastrophe.

21 January 2018

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Neosis: a novel type of cell division in cancer.

21 January 2018

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Genetic stability of senescence reverted cells: genome reduction division of polyploidy cells, aneuploidy and neoplasia

21 January 2018

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Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.

21 January 2018

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Survivin and escaping in therapy-induced cellular senescence

21 January 2018

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Expression of coxsackie and adenovirus receptor distinguishes transitional cancer states in therapy-induced cellular senescence

21 January 2018

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CDK inhibitors: positive and negative regulators of G1-phase progression

21 January 2018

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Skp2-mediated degradation of p27 regulates progression into mitosis

21 January 2018

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Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy.

21 January 2018

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Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells

21 January 2018

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Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2.

21 January 2018

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Novel alterations in CDK1/cyclin B1 kinase complex formation occur during the acquisition of a polyploid DNA content

21 January 2018

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The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase

21 January 2018

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SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition

21 January 2018

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Construction by gene targeting in human cells of a "conditional' CDC2 mutant that rereplicates its DNA.

21 January 2018

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Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin

21 January 2018

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Computerized Video Time-Lapse (CVTL) Analysis of the Fate of Giant Cells Produced by X-Irradiating EJ30 Human Bladder Carcinoma Cells

21 January 2018

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Release of mitotic descendants by giant cells from irradiated Burkitt's lymphoma cell line..

21 January 2018

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Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe.

21 January 2018

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CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

21 January 2018

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Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair

21 January 2018

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DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

21 January 2018

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The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy

21 January 2018

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A non-enzymatic p21 protein inhibitor of stress-activated protein kinases

21 January 2018

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Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

21 January 2018

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Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy

21 January 2018

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Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo

21 January 2018

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Cellular senescence predicts treatment outcome in metastasised colorectal cancer.

21 January 2018

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Endopolyploid cells produced after severe genotoxic damage have the potential to repair DNA double strand breaks

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IJC.27810

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30 May 2018

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30 May 2018