(Q54487327)

30 May 2018

title

Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis. (English)

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30 May 2018

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2

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Yin Xiao

series ordinal

3

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30 May 2018

author name string

Jiezhong Chen

series ordinal

1

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30 May 2018

publication date

1 February 2013

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30 May 2018

Journal of Cellular Biochemistry

published in

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30 May 2018

volume

114

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issue

2

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30 May 2018

page(s)

245-249

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30 May 2018

Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model

cites work

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21 January 2018

1 reference

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Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.

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Cytokines, tumor necrosis factor-alpha and interleukin-1beta, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes.

21 January 2018

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Interleukin-1beta and interleukin-6 disturb the antioxidant enzyme system in bovine chondrocytes: a possible explanation for oxidative stress generation

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Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival

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IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways

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21 January 2018

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21 January 2018

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21 January 2018

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Aggravation of ADAMTS and matrix metalloproteinase production and role of ERK1/2 pathway in the interaction of osteoarthritic subchondral bone osteoblasts and articular cartilage chondrocytes -- possible pathogenic role in osteoarthritis.

21 January 2018

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Inhibition of p38 pathway leads to OA-like changes in a rat animal model

21 January 2018

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A systematic review on changed biomechanics of lower extremities in obese individuals: a possible role in development of osteoarthritis

21 January 2018

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Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

21 January 2018

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Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4

21 January 2018

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Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes

21 January 2018

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Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells

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Proteases involved in cartilage matrix degradation in osteoarthritis.

21 January 2018

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Sulforaphane protects human chondrocytes against cell death induced by various stimuli

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Suppression of NF-κB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCB.24362

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30 May 2018

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30 May 2018