(Q54498929)

30 May 2018

title

MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia. (English)

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30 May 2018

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4

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Oliver Ottmann

5

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author name string

F J Giles

1

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R T Swords

2

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A Nagler

3

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D A Rizzieri

6

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M Talpaz

7

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J Clark

8

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P Watson

9

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A Xiao

10

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B Zhao

11

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D Bergstrom

12

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P D Le Coutre

13

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S J Freedman

14

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J E Cortes

15

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publication date

9 July 2012

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published in

Leukemia

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volume

27

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issue

1

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page(s)

113-117

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https://scigraph.springernature.com/pub.10.1038/leu.2012.186

exact match

0 references

cites work

Therapeutic advances in acute myeloid leukemia

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Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

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The chromosomal passenger complex: one for all and all for one.

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The cellular geography of aurora kinases

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Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3

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Update on Aurora Kinase Targeted Therapeutics in Oncology

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A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

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Tumour-amplified kinase BTAK is amplified and overexpressed in gastric cancers with possible involvement in aneuploid formation

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Aurora A and B kinases--targets of novel anticancer drugs

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Aurora B: a new prognostic marker and therapeutic target in cancer

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

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VX-680 inhibits Aurora A and Aurora B kinase activity in human cells.

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The discovery of the potent aurora inhibitor MK-0457 (VX-680).

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Structural basis for potent inhibition of the Aurora kinases and a T315I multi-drug resistant mutant form of Abl kinase by VX-680.

21 January 2018

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Phase I dose escalation study of MK-0457, a novel Aurora kinase inhibitor, in adult patients with advanced solid tumors

21 January 2018

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Epidemiologic study on survival of chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia patients with BCR-ABL T315I mutation

21 January 2018

1 reference

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Combining histone deacetylase inhibitor vorinostat with aurora kinase inhibitors enhances lymphoma cell killing with repression of c-Myc, hTERT, and microRNA levels

21 January 2018

1 reference

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Mechanism of MK-0457 efficacy against BCR-ABL positive leukemia cells

21 January 2018

1 reference

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HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo

21 January 2018

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The Aurora kinase inhibitor VX-680 induces endoreduplication and apoptosis preferentially in cells with compromised p53-dependent postmitotic checkpoint function

21 January 2018

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Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53.

21 January 2018

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Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

21 January 2018

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Phase 1/2 study to assess the safety, efficacy, and pharmacokinetics of barasertib (AZD1152) in patients with advanced acute myeloid leukemia

21 January 2018

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A Phase I study to assess the safety, pharmacokinetics and efficacy of barasertib (AZD1152), an Aurora B kinase inhibitor, in Japanese patients with advanced acute myeloid leukemia.

21 January 2018

1 reference

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Targets and effectors of the cellular response to aurora kinase inhibitor MK-0457 (VX-680) in imatinib sensitive and resistant chronic myelogenous leukemia

21 January 2018

1 reference

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Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias

21 January 2018

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https://api.crossref.org/works/10.1038%2FLEU.2012.186

The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukaemia and significantly increases the efficacy of nilotinib

21 January 2018

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Targeting aurora kinases in cancer treatment

21 January 2018

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The potential role of Aurora kinase inhibitors in haematological malignancies

21 January 2018

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MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2012.186

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/LEU.2012.186

1 reference

30 May 2018

PubMed ID

22772060

1 reference

30 May 2018