(Q54652255)

2 June 2018

title

Cathelicidin peptide LL-37 modulates TREM-1 expression and inflammatory responses to microbial compounds. (English)

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2 June 2018

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4

Robert E W Hancock

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2 June 2018

author name string

Gimano D Amatngalim

series ordinal

1

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2 June 2018

Anastasia Nijnik

series ordinal

2

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2 June 2018

Pieter S Hiemstra

series ordinal

3

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2 June 2018

publication date

1 October 2011

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2 June 2018

published in

Inflammation

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2 June 2018

volume

34

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2 June 2018

issue

5

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2 June 2018

page(s)

412-425

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2 June 2018

https://scigraph.springernature.com/pub.10.1007/s10753-010-9248-6

exact match

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cites work

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Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3

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Transfer of a cathelicidin peptide antibiotic gene restores bacterial killing in a cystic fibrosis xenograft model

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The anti-microbial peptide LL-37 inhibits the activation of dendritic cells by TLR ligands.

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Differing effects of exogenous or endogenous cathelicidin on macrophage toll-like receptor signaling

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Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization.

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The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor.

21 January 2018

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A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release

21 January 2018

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Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells

21 January 2018

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The cathelicidin LL-37 activates human mast cells and is degraded by mast cell tryptase: counter-regulation by CXCL4.

21 January 2018

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Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

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Self-RNA-antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8.

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Neutrophil secondary necrosis is induced by LL-37 derived from cathelicidin

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The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system.

21 January 2018

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An antimicrobial cathelicidin peptide, human CAP18/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7.

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Systems biology evaluation of immune responses induced by human host defence peptide LL-37 in mononuclear cells

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LL-37 enhances adaptive antitumor immune response in a murine model when genetically fused with M-CSFR (J6-1) DNA vaccine.

21 January 2018

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Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant.

21 January 2018

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Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea

21 January 2018

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21 January 2018

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21 January 2018

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The TREM receptor family and signal integration

21 January 2018

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Regulation of TREM expression in hepatic macrophages and endothelial cells during acute endotoxemia

21 January 2018

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21 January 2018

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Modulation of the triggering receptor expressed on the myeloid cell type 1 pathway in murine septic shock

21 January 2018

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TREM-1 ligand expression on platelets enhances neutrophil activation

21 January 2018

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Triggering receptor expressed on myeloid cells (TREM-1) is regulated post-transcriptionally and its ligand is present in the sera of some septic patients.

21 January 2018

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21 January 2018

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21 January 2018

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TREM-1 amplifies inflammation and is a crucial mediator of septic shock

21 January 2018

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Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors

21 January 2018

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TREM-1--expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases

21 January 2018

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Effects of the TREM 1 pathway modulation during hemorrhagic shock in rats

21 January 2018

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TREM-1 activation alters the dynamics of pulmonary IRAK-M expression in vivo and improves host defense during pneumococcal pneumonia

21 January 2018

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TREM-1 promotes survival during septic shock in mice.

21 January 2018

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A new mathematical model for relative quantification in real-time RT-PCR

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia

21 January 2018

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https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Metalloproteinases shed TREM-1 ectodomain from lipopolysaccharide-stimulated human monocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2.

21 January 2018

1 reference

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Intracellular NOD-like receptors in host defense and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Staphylococcus aureus peptidoglycan is a toll-like receptor 2 activator: a reevaluation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Toll-like receptor signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Harmful molecular mechanisms in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Bovine and human cathelicidin cationic host defense peptides similarly suppress transcriptional responses to bacterial lipopolysaccharide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Human cathelicidin peptide LL-37 modulates the effects of IFN-gamma on APCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Innate immune recognition of microbes through Nod1 and Nod2: implications for disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Intracellular receptor for human host defense peptide LL-37 in monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

The human antimicrobial peptide LL-37 transfers extracellular DNA plasmid to the nuclear compartment of mammalian cells via lipid rafts and proteoglycan-dependent endocytosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10753-010-9248-6

Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2

21 January 2018

1 reference

12 December 2020

Host defense peptide LL-37, in synergy with inflammatory mediator IL-1beta, augments immune responses by multiple pathways

1 reference

12 December 2020

MYD88-dependent and -independent activation of TREM-1 via specific TLR ligands

1 reference

12 December 2020

Procedure for isolation of bacterial lipopolysaccharides from both smooth and rough Pseudomonas aeruginosa and Salmonella typhimurium strains.

1 reference

12 December 2020

10.1007/S10753-010-9248-6

Identifiers

DOI

1 reference

2 June 2018

PubMed ID

20811938

1 reference

2 June 2018