(Q54676348)

2 June 2018

title

The MRE11-RAD50-XRS2 complex, in addition to other non-homologous end-joining factors, is required for V(D)J joining in yeast. (English)

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2 June 2018

author

James E. Haber

3

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2 June 2018

author name string

Anne E Clatworthy

1

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2 June 2018

Maria A Valencia-Burton

2

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2 June 2018

Marjorie A Oettinger

4

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2 June 2018

language of work or name

English

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publication date

9 March 2005

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2 June 2018

Journal of Biological Chemistry

published in

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2 June 2018

volume

280

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2 June 2018

issue

21

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2 June 2018

page(s)

20247-20252

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2 June 2018

The phylogenetic origins of the antigen-binding receptors and somatic diversification mechanisms

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Separation-of-function mutants reveal critical roles for RAG2 in both the cleavage and joining steps of V(D)J recombination

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Mutational analysis of all conserved basic amino acids in RAG-1 reveals catalytic, step arrest, and joining-deficient mutants in the V(D)J recombinase

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Evidence of a critical architectural function for the RAG proteins in end processing, protection, and joining in V(D)J recombination

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A stable RAG1-RAG2-DNA complex that is active in V(D)J cleavage

21 January 2018

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RAG1 and RAG2 form a stable postcleavage synaptic complex with DNA containing signal ends in V(D)J recombination

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Assembly of a 12/23 paired signal complex: a critical control point in V(D)J recombination

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Intermediates in V(D)J recombination: a stable RAG1/2 complex sequesters cleaved RSS ends.

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Cell cycle-dependent accumulation in vivo of transposition-competent complexes between recombination signal ends and full-length RAG proteins

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RAG proteins shepherd double-strand breaks to a specific pathway, suppressing error-prone repair, but RAG nicking initiates homologous recombination.

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Late embryonic lethality and impaired V(D)J recombination in mice lacking DNA ligase IV

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DNA binding of Xrcc4 protein is associated with V(D)J recombination but not with stimulation of DNA ligase IV activity

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Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

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Requirement for an interaction of XRCC4 with DNA ligase IV for wild-type V(D)J recombination and DNA double-strand break repair in vivo.

21 January 2018

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Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

21 January 2018

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Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination

21 January 2018

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Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice

21 January 2018

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Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency.

21 January 2018

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Role of PSO genes in repair of DNA damage of Saccharomyces cerevisiae

21 January 2018

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Microhomology-dependent end joining and repair of transposon-induced DNA hairpins by host factors in Saccharomyces cerevisiae.

21 January 2018

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Nonhomologous end joining and V(D)J recombination require an additional factor

21 January 2018

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

21 January 2018

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Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

21 January 2018

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Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae

21 January 2018

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Response to RAG-mediated VDJ cleavage by NBS1 and gamma-H2AX

21 January 2018

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In situ visualization of DNA double-strand break repair in human fibroblasts

21 January 2018

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Nibrin functions in Ig class-switch recombination

21 January 2018

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Delineation of the role of the Mre11 complex in class switch recombination

21 January 2018

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Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1.

21 January 2018

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The 3' to 5' exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks

21 January 2018

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Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95

21 January 2018

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Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction

21 January 2018

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Novel functional requirements for non-homologous DNA end joining in Schizosaccharomyces pombe.

21 January 2018

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Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells

21 January 2018

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The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

21 January 2018

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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

21 January 2018

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Normal V(D)J recombination in cells from patients with Nijmegen breakage syndrome

21 January 2018

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Cancer predisposition and hematopoietic failure in Rad50(S/S) mice

21 January 2018

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Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice

21 January 2018

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An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

21 January 2018

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Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ataxia-telangiectasia-like disorder mutant complexes.

21 January 2018

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An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability.

21 January 2018

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V(D)J recombination and RAG-mediated transposition in yeast.

21 January 2018

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Saccharomyces cerevisiae LIF1: a function involved in DNA double-strand break repair related to mammalian XRCC4.

21 January 2018

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A DNA microarray-based genetic screen for nonhomologous end-joining mutants in Saccharomyces cerevisiae

21 January 2018

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NEJ1 controls non-homologous end joining in Saccharomyces cerevisiae

21 January 2018

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Nej1p, a cell type-specific regulator of nonhomologous end joining in yeast

21 January 2018

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NHEJ regulation by mating type is exercised through a novel protein, Lif2p, essential to the ligase IV pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

The RAD52 gene is required for homothallic interconversion of mating types and spontaneous mitotic recombination in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

The RAG proteins and V(D)J recombination: complexes, ends, and transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

HDF2, the second subunit of the Ku homologue from Saccharomyces cerevisiae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

Identification of Saccharomyces cerevisiae DNA ligase IV: involvement in DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

A mechanistic basis for Mre11-directed DNA joining at microhomologies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

The Nijmegen breakage syndrome protein is essential for Mre11 phosphorylation upon DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

The yeast Xrs2 complex functions in S phase checkpoint regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

ATM-dependent phosphorylation of nibrin in response to radiation exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

Human Rad50/Mre11 is a flexible complex that can tether DNA ends

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M500126200

Cell-free V(D)J recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500126200

21 January 2018

Identifiers

DOI

10.1074/JBC.M500126200

1 reference

2 June 2018

PubMed ID

15757898

1 reference

2 June 2018