(Q54678246)

2 June 2018

title

Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias. (English)

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2 June 2018

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Naoyuki Homma

1

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2 June 2018

Gen Tamura

2

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2 June 2018

Teiichiro Honda

3

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2 June 2018

Zhe Jin

4

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2 June 2018

Kiyonari Ohmura

5

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2 June 2018

Sumio Kawata

6

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2 June 2018

Teiichi Motoyama

7

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2 June 2018

publication date

10 December 2004

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2 June 2018

published in

Virchows Archiv

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2 June 2018

volume

446

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2 June 2018

issue

2

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2 June 2018

page(s)

120-126

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2 June 2018

https://scigraph.springernature.com/pub.10.1007/s00428-004-1146-6

exact match

0 references

cites work

Methylation-induced G2/M arrest requires a full complement of the mismatch repair protein hMLH1

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12 December 2020

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

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12 December 2020

Concerted promoter hypermethylation of hMLH1, p16INK4A, and E-cadherin in gastric carcinomas with microsatellite instability

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12 December 2020

Oncofetal mucin M1 epitope family: characterization and expression during colonic carcinogenesis.

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12 December 2020

Mutational inactivation of mitotic checkpoint genes, hsMAD2 and hBUB1, is rare in sporadic digestive tract cancers.

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12 December 2020

Epigenetic inactivation of CHFR in human tumors

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12 December 2020

Characterization of MAD2B and other mitotic spindle checkpoint genes

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12 December 2020

Gastric dysplasia: the Padova international classification

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12 December 2020

A National Cancer Institute Workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer

1 reference

12 December 2020

Hypermethylation of the hMLH1 gene promoter in solitary and multiple gastric cancers with microsatellite instability

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12 December 2020

Microsatellite alterations in differentiated-type adenocarcinomas and precancerous lesions of the stomach with special reference to cellular phenotype

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12 December 2020

Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses.

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12 December 2020

Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors.

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12 December 2020

Cancer epigenetics comes of age

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12 December 2020

Genetic instabilities in human cancers

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12 December 2020

DNA aneuploidy by flow cytometry is an independent prognostic factor in gastric cancer.

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12 December 2020

Loss of heterozygosity during the development and progression of differentiated adenocarcinoma of the stomach

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12 December 2020

Allelotype of adenoma and differentiated adenocarcinoma of the stomach

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12 December 2020

Chfr expression is downregulated by CpG island hypermethylation in esophageal cancer

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12 December 2020

Molecular characterization of undifferentiated-type gastric carcinoma

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12 December 2020

Concurrent hypermethylation of gene promoters is associated with a MSI-H phenotype and diploidy in gastric carcinomas.

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12 December 2020

Microsatellite alterations and target gene mutations in the early stages of multiple gastric cancer

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12 December 2020

Genetic and epigenetic alterations of tumor suppressor and tumor-related genes in gastric cancer

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12 December 2020

Chfr defines a mitotic stress checkpoint that delays entry into metaphase

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12 December 2020

Somatic mutation of the hBUB1 mitotic checkpoint gene in primary lung cancer

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12 December 2020

Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia

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12 December 2020

Mutations of mitotic checkpoint genes in human cancers

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12 December 2020

Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers

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12 December 2020

Chfr regulates a mitotic stress pathway through its RING-finger domain with ubiquitin ligase activity

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12 December 2020

Inverse relationship between APC gene mutation in gastric adenomas and development of adenocarcinoma

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12 December 2020

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint

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12 December 2020

Identification of a human mitotic checkpoint gene: hsMAD2

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12 December 2020

Molecular and cellular phenotypic profiles of gastric noninvasive neoplasia.

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12 December 2020

Molecular pathogenesis of adenoma and differentiated adenocarcinoma of the stomach

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12 December 2020

Frequent hypermethylation of the hMLH1 gene promoter in differentiated-type tumors of the stomach with the gastric foveolar phenotype

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12 December 2020

Chromosomes, genes, and cancer

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12 December 2020

Mismatch repair, G(2)/M cell cycle arrest and lethality after DNA damage.

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12 December 2020

Biosynthesis of human colonic mucin: Muc2 is the prominent secretory mucin

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12 December 2020

Frequent hypermethylation of the 5' CpG island of the mitotic stress checkpoint gene Chfr in colorectal and non-small cell lung cancer

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12 December 2020

Promoter methylation status of E-cadherin, hMLH1, and p16 genes in nonneoplastic gastric epithelia

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12 December 2020

Detection of frequent p53 gene mutations in primary gastric cancer by cell sorting and polymerase chain reaction single-strand conformation polymorphism analysis.

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12 December 2020

A neutral endopeptidase in the microvillar membrane of pig intestine. Partial purification and properties

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12 December 2020

10.1007/S00428-004-1146-6

Identifiers

DOI

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2 June 2018

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2 June 2018