(Q54799136)

3 June 2018

title

DNA polymerase eta is a limiting factor for A:T mutations in Ig genes and contributes to antibody affinity maturation. (English)

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3 June 2018

author

Masayuki Yokoi

3

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3 June 2018

author name string

Keiji Masuda

1

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3 June 2018

Rika Ouchida

2

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3 June 2018

Fumio Hanaoka

4

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3 June 2018

Takachika Azuma

5

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3 June 2018

Ji-Yang Wang

6

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3 June 2018

language of work or name

English

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publication date

1 October 2008

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3 June 2018

European Journal of Immunology

published in

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3 June 2018

volume

38

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3 June 2018

issue

10

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3 June 2018

page(s)

2796-2805

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3 June 2018

Molecular mechanisms of antibody somatic hypermutation.

cites work

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Transcription-targeted DNA deamination by the AID antibody diversification enzyme

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Somatic hypermutation: subverted DNA repair

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

AID in somatic hypermutation and class switch recombination

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Absence of DNA polymerase theta results in decreased somatic hypermutation frequency and altered mutation patterns in Ig genes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Hot spot focusing of somatic hypermutation in MSH2-deficient mice suggests two stages of mutational targeting

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Mismatch repair deficiency interferes with the accumulation of mutations in chronically stimulated B cells and not with the hypermutation process

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

A role for Msh6 but not Msh3 in somatic hypermutation and class switch recombination

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversification

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

hRAD30 mutations in the variant form of xeroderma pigmentosum

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Low fidelity DNA synthesis by human DNA polymerase-eta

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Proofreading of DNA polymerase eta-dependent replication errors

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Error rate and specificity of human and murine DNA polymerase eta

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Somatic mutation hotspots correlate with DNA polymerase eta error spectrum.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

DNA polymerase theta is preferentially expressed in lymphoid tissues and upregulated in human cancers

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Mutation frequency vs. mutation patterns: a comparison of the results in spleen and Peyer's patches

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Junctional amino acids determine the maturation pathway of an antibody.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Involvement of Rad18 in somatic hypermutation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

A role for PCNA ubiquitination in immunoglobulin hypermutation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Interaction of hREV1 with three human Y-family DNA polymerases

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

The Y-family of DNA polymerases

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

The absence of DNA polymerase kappa does not affect somatic hypermutation of the mouse immunoglobulin heavy chain gene.

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

129-derived strains of mice are deficient in DNA polymerase iota and have normal immunoglobulin hypermutation

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Normal immunoglobulin gene somatic hypermutation in Pol kappa-Pol iota double-deficient mice

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota

1 reference

https://api.crossref.org/works/10.1002%2FEJI.200838502

7 January 2021

Identifiers

DOI

10.1002/EJI.200838502

1 reference

3 June 2018

1 reference

3 June 2018