(Q55266073)

29 June 2018

title

Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway. (English)

1 reference

29 June 2018

11

Sarath Chandra Janga

0 references

Sophie Paczesny

13

object named as

Sophie Paczesny

1 reference

29 June 2018

7

Bart Vanhaesebroeck

1 reference

29 June 2018

author name string

Lakshmi Reddy Palam

1

1 reference

29 June 2018

Raghuveer Singh Mali

2

1 reference

29 June 2018

Baskar Ramdas

3

1 reference

29 June 2018

Sridhar Nonavinkere Srivatsan

4

1 reference

29 June 2018

Valeria Visconte

5

1 reference

29 June 2018

Ramon V Tiu

6

1 reference

29 June 2018

Axel Roers

8

1 reference

29 June 2018

Alexander Gerbaulet

9

1 reference

29 June 2018

Mingjiang Xu

10

1 reference

29 June 2018

Clifford M Takemoto

12

1 reference

29 June 2018

Reuben Kapur

14

1 reference

29 June 2018

publication date

22 February 2018

1 reference

29 June 2018

published in

JCI insight

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29 June 2018

volume

3

1 reference

29 June 2018

issue

4

1 reference

29 June 2018

describes a project that uses

Cytoscape

1 reference

9 June 2022

https://europepmc.org/search?query=(METHODS:'Cytoscape')

based on heuristic

inferred from PubMed Central ID database lookup

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5916249/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis

30 June 2018

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Antagonistic regulation by the transcription factors C/EBPα and MITF specifies basophil and mast cell fates

30 June 2018

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PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma

30 June 2018

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30 June 2018

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30 June 2018

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Single nucleotide polymorphism array lesions, TET2, DNMT3A, ASXL1 and CBL mutations are present in systemic mastocytosis.

30 June 2018

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Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

30 June 2018

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PTEN deficiency in mast cells causes a mastocytosis-like proliferative disease that heightens allergic responses and vascular permeability

30 June 2018

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Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies

30 June 2018

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Balanced interactions between Lyn, the p85alpha regulatory subunit of class I(A) phosphatidylinositol-3-kinase, and SHIP are essential for mast cell growth and maturation

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

The PI3K pathway drives the maturation of mast cells via microphthalmia transcription factor

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

AP-1 regulates cyclin D1 and c-MYC transcription in an AKT-dependent manner in response to mTOR inhibition: role of AIP4/Itch-mediated JUNB degradation

30 June 2018

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Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Vitamin C promotes widespread yet specific DNA demethylation of the epigenome in human embryonic stem cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Rank-rank hypergeometric overlap: identification of statistically significant overlap between gene-expression signatures

30 June 2018

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Systemic mastocytosis in adults: a review on prognosis and treatment based on 342 Mayo Clinic patients and current literature

30 June 2018

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30 June 2018

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30 June 2018

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates

30 June 2018

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30 June 2018

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Nucleophosmin interacts directly with c-Myc and controls c-Myc-induced hyperproliferation and transformation

30 June 2018

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Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis

30 June 2018

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The activated Notch1 receptor cooperates with alpha-enolase and MBP-1 in modulating c-myc activity.

30 June 2018

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Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1.

30 June 2018

1 reference

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Mast cell transcriptional networks

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Requirement for p85alpha regulatory subunit of class IA PI3K in myeloproliferative disease driven by an activation loop mutant of KIT.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

c-myc promoter binding protein regulates the cellular response to an altered glucose concentration

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Genetic and pharmacologic evidence implicating the p85 alpha, but not p85 beta, regulatory subunit of PI3K and Rac2 GTPase in regulating oncogenic KIT-induced transformation in acute myeloid leukemia and systemic mastocytosis

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Activity of AMN107, a novel aminopyrimidine tyrosine kinase inhibitor, against human FIP1L1-PDGFR-alpha-expressing cells

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Class IA phosphoinositide 3-kinase regulates heart size and physiological cardiac hypertrophy

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

BiQ Analyzer: visualization and quality control for DNA methylation data from bisulfite sequencing.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Mastocytosis: pathology, genetics, and current options for therapy

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

A strategy for identifying transcription factor binding sites reveals two classes of genomic c-Myc target sites

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

MethPrimer: designing primers for methylation PCRs

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

The identification and functional characterization of a novel mast cell isoform of the microphthalmia-associated transcription factor

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Regulation of mast cell phenotype by MITF.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Diagnostic criteria and classification of mastocytosis: a consensus proposal

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

KEGG: kyoto encyclopedia of genes and genomes

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis.

30 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

PI3K signalling: the path to discovery and understanding.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Mutations galore in myeloproliferative neoplasms: would the real Spartacus please stand up?

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Mast cell hyperplasia, B-cell malignancy, and intestinal inflammation in mice with conditional expression of a constitutively active kit.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Myc-mediated transcriptional repression by recruitment of histone deacetylase.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

Identification of a committed precursor for the mast cell lineage.

12 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5916249

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients

12 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/29467326

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI.INSIGHT.94679

1 reference

29 June 2018

PMC publication ID

5916249

1 reference

29 June 2018

PubMed publication ID

29467326

1 reference

29 June 2018