(Q51093052)

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NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components.

scientific article published on 21 March 2017

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13 March 2020

NOTCH1-mutated chronic lymphocytic leukemia cells are characterized by a MYC-related overexpression of nucleophosmin 1 and ribosome-associated components (English)

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13 March 2020

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chronic lymphocytic leukemia

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Antonella Zucchetto

7

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13 March 2020

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13 March 2020

Elena Vendramini

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13 March 2020

Riccardo Bomben

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13 March 2020

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13 March 2020

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13 March 2020

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13 March 2020

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13 March 2020

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T Bittolo

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13 March 2020

P Bulian

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13 March 2020

F M Rossi

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13 March 2020

G D'Arena

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13 March 2020

F Di Raimondo

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13 March 2020

G Pozzato

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13 March 2020

D Rossi

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13 March 2020

G Gaidano

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13 March 2020

G Del Poeta

16

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13 March 2020

M Dal Bo

18

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13 March 2020

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21 March 2017

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13 March 2020

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13 March 2020

31

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13 March 2020

11

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13 March 2020

2407-2415

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13 March 2020

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Chronic lymphocytic leukemia: 2013 update on diagnosis, risk stratification and treatment

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Mutations of NOTCH1 are an independent predictor of survival in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

NOTCH1 mutations in +12 chronic lymphocytic leukemia (CLL) confer an unfavorable prognosis, induce a distinctive transcriptional profiling and refine the intermediate prognosis of +12 CLL

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Notch signalling: a simple pathway becomes complex

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Notch signalling in context

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Functions of notch signaling in the immune system: consensus and controversies

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Dynamic binding of RBPJ is determined by Notch signaling status.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Masking of the CBF1/RBPJ kappa transcriptional repression domain by Epstein-Barr virus EBNA2.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

HES and HERP families: multiple effectors of the Notch signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Myc is a Notch1 transcriptional target and a requisite for Notch1-induced mammary tumorigenesis in mice

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Stromal cell-mediated glycolytic switch in CLL cells involves Notch-c-Myc signaling.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Interferon regulatory factor 4 attenuates Notch signaling to suppress the development of chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

NOTCH1 mutations identify a chronic lymphocytic leukemia patient subset with worse prognosis in the setting of a rituximab-based induction and consolidation treatment.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

NOTCH1 mutations associate with low CD20 level in chronic lymphocytic leukemia: evidence for a NOTCH1 mutation-driven epigenetic dysregulation.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

CD49d prevails over the novel recurrent mutations as independent prognosticator of overall survival in chronic lymphocytic leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Genomic aberrations and survival in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Integrative Genomics Viewer (IGV): high-performance genomics data visualization and exploration

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Toll-like receptor agonists induce apoptosis in mouse B-cell lymphoma cells by altering NF-κB activation

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

The miR-17∼92 family regulates the response to Toll-like receptor 9 triggering of CLL cells with unmutated IGHV genes.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Mechanism and function of a newly identified CpG DNA motif in human primary B cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Mouse jagged1 physically interacts with notch2 and other notch receptors. Assessment by quantitative methods

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and -independent mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Constitutive activation of NF-κB signaling by NOTCH1 mutations in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

GOTree Machine (GOTM): a web-based platform for interpreting sets of interesting genes using Gene Ontology hierarchies

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Calcium depletion dissociates and activates heterodimeric notch receptors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Human deltex is a conserved regulator of Notch signalling

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

MYC as a regulator of ribosome biogenesis and protein synthesis

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

c-myc gene is transcribed at high rate in G0-arrested fibroblasts and is post-transcriptionally regulated in response to growth factors

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Rapid cytoplasmic turnover of c-myc mRNA: requirement of the 3' untranslated sequences

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Reflecting on 25 years with MYC.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Translation initiation by the c-myc mRNA internal ribosome entry sequence and the poly(A) tail.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Transcription regulation of the rRNA gene by a multifunctional nucleolar protein, B23/nucleophosmin, through its histone chaperone activity

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Arsenic trioxide and all-trans retinoic acid target NPM1 mutant oncoprotein levels and induce apoptosis in NPM1-mutated AML cells.

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Non-coding recurrent mutations in chronic lymphocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

21 January 2018

Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

7 January 2021

based on heuristic

inferred from DOI database lookup

NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

7 January 2021

based on heuristic

inferred from DOI database lookup

Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: costimulation with IL-2 results in a highly immunogenic phenotype

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

7 January 2021

based on heuristic

inferred from DOI database lookup

Progressive ankylosis protein (ANK) in osteoblasts and osteoclasts controls bone formation and bone remodeling

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype

1 reference

https://api.crossref.org/works/10.1038%2FLEU.2017.90

7 January 2021

based on heuristic

inferred from DOI database lookup

The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL

1 reference

https://pubmed.ncbi.nlm.nih.gov/28321119

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/28321119

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/LEU.2017.90

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28321119%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28321119%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

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