(Q55461978)

English

2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defense.

scientific article

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

2-Deoxy-D-glucose and 6-aminonicotinamide-mediated Nrf2 down regulation leads to radiosensitization of malignant cells via abrogation of GSH-mediated defense. (English)

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

0 references

Rajeev Kumar Varshney

2

object named as

Rajeev Varshney

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

author name string

Pradeep Kumar Sharma

1

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

publication date

1 October 2012

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

Free Radical Research

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

46

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

12

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

1446-1457

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Molecular mechanism activating Nrf2-Keap1 pathway in regulation of adaptive response to electrophiles

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Impaired expression of glutathione synthetic enzyme genes in mice with targeted deletion of the Nrf2 basic-leucine zipper protein

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Thioredoxin-dependent redox regulation of the antioxidant responsive element (ARE) in electrophile response

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Nrf2 is essential for protection against acute pulmonary injury in mice

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Transcription factor Nrf2 is required for the constitutive and inducible expression of multidrug resistance-associated protein1 in mouse embryo fibroblasts

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Nrf2 as a target for cancer chemoprevention

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Gain of Nrf2 function in non-small-cell lung cancer cells confers radioresistance.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

The world according to Maf

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Energy linked modifications of the radiation response in a human cerebral glioma cell line

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Heterogeneity in 2-deoxy-D-glucose-induced modifications in energetics and radiation responses of human tumor cell lines

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Radiosensitization of murine Ehrlich ascites tumor by a combination of 2-deoxy-D-glucose and 6-aminonicotinamide

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Metabolic oxidative stress induced by a combination of 2-DG and 6-AN enhances radiation damage selectively in malignant cells via non-coordinated expression of antioxidant enzymes

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces oxidative stress mediated selective radiosensitization of malignant cells via mitochondrial dysfunction

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

A combination of 2-deoxy-D-glucose and 6-aminonicotinamide induces cell cycle arrest and apoptosis selectively in irradiated human malignant cells

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Antioxidant enzyme mRNA expression in conjunctival epithelium of healthy human subjects.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Expression of gamma-glutamylcysteine synthetase (gamma-GCS) and multidrug resistance-associated protein (MRP), but not human canalicular multispecific organic anion transporter (cMOAT), genes correlates with exposure of human lung cancers to platinu

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Reoxygenation-specific activation of the antioxidant transcription factor Nrf2 mediates cytoprotective gene expression in ischemia-reperfusion injury

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Hypermethylation of the Keap1 gene in human lung cancer cell lines and lung cancer tissues

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Regulation of glutathione synthesis

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Nrf2-regulated glutathione recycling independent of biosynthesis is critical for cell survival during oxidative stress

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Glucose deprivation-induced cytotoxicity and alterations in mitogen-activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Loss of Kelch-like ECH-associated protein 1 function in prostate cancer cells causes chemoresistance and radioresistance and promotes tumor growth.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Nuclear factor (erythroid-derived 2)-like 2 regulates drug resistance in pancreatic cancer cells

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Ionizing radiation activates the Nrf2 antioxidant response

1 reference

https://api.crossref.org/works/10.3109%2F10715762.2012.724771

21 January 2018

Identifiers

10.3109/10715762.2012.724771

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

12 July 2018

http://europepmc.org/abstract/MED/22946929

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q55461978&oldid=1799267679"