(Q55477468)

12 July 2018

title

Studies on the teratogen pharmacophore of valproic acid analogues: evidence of interactions at a hydrophobic centre. (English)

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12 July 2018

1 reference

Bojic U

1

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12 July 2018

Ehlers K

2

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12 July 2018

Ellerbeck U

3

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12 July 2018

Bacon CL

4

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12 July 2018

O'Driscoll E

5

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12 July 2018

O'Connell C

6

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12 July 2018

Berezin V

7

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12 July 2018

Kawa A

8

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12 July 2018

Lepekhin E

9

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12 July 2018

Bock E

10

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12 July 2018

Regan CM

11

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12 July 2018

Nau H

12

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12 July 2018

language of work or name

English

0 references

publication date

1 August 1998

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12 July 2018

European Journal of Pharmacology

published in

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12 July 2018

volume

354

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12 July 2018

issue

2-3

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12 July 2018

page(s)

289-299

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12 July 2018

Valproic acid suppresses G1 phase-dependent sialylation of a 65kDa glycoprotein in the C6 glioma cell cycle.

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Cell proliferation, migration and CAM-dependent neurite outgrowth as developmental in vitro endpoints for screening teratogenic potential: Application to valproic acid and related analogues of varying potency.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Teratogenic potency of valproate analogues evaluated by quantitative estimation of cellular morphology in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Neurite outgrowth on muscle cell surfaces involves extracellular matrix receptors as well as Ca2+-dependent and -independent cell adhesion molecules

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Clusters of neural cell adhesion molecule at sites of cell-cell contact

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Further branching of valproate-related carboxylic acids reduces the teratogenic activity, but not the anticonvulsant effect

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Quantitative correspondence between the in vivo and in vitro activity of teratogenic agents

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Chronic sodium valproate selectively decreases protein kinase C alpha and epsilon in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Effects of valproic acid on beta-adrenergic receptors, G-proteins, and adenylyl cyclase in rat C6 glioma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Correlation of in vitro anti-proliferative potential with in vivo teratogenicity in a series of valproate analogues.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Marked accumulation of valproic acid in embryonic neuroepithelium of the mouse during early organogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

A threshold effect of the major isoforms of NCAM on neurite outgrowth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Quantitative determination of valproic acid and 14 metabolites in serum and urine by gas chromatography/mass spectrometry

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Stereospecific effects of inhalational general anesthetic optical isomers on nerve ion channels

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Molecular and cellular mechanisms of general anaesthesia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Cell adhesion molecules in the early developing mouse retina: retinal neurons show preferential outgrowth in vitro on L1 but not N-CAM.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

[Structural bases of the teratogenic effects of the antiepileptic valproic acid. 2-n-propyl-4-pentenic acid, the first structural analogue with significantly higher teratogenic action than VPA].

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

The enantiomers of the valproic acid analogue 2-n-propyl-4-pentynoic acid (4-yn-VPA): asymmetric synthesis and highly stereoselective teratogenicity in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

The enantioselective teratogenicity of 2-n-propyl-4-pentynoic acid (4-yn-VPA) is due to stereoselective intrinsic activity and not differences in pharmacokinetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Up-regulation of embryonic NCAM in an EC cell line by retinoic acid

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Effects of the antiepileptic drug valproate on metabolism and function of inhibitory and excitatory amino acids in the brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

In vitro screening for anticonvulsant-induced teratogenesis: Drug alteration of cell adhesivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

The anticonvulsant sodium valproate specifically induces the expression of a rat glial heat shock protein which is identified as the collagen type IV receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

The anticonvulsant valproate teratogen restricts the glial cell cycle at a defined point in the mid-G1 phase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Perturbations of cellular functions integral to neural tube formation by the putative teratogen sodium valproate.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Valproic acid teratogenicity in mice after various administration and phenobarbital-pretreatment regimens: the parent drug and not one of the metabolites assayed is implicated as teratogen

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Transfer of valproic acid and its main active unsaturated metabolite to the gestational tissue: correlation with neural tube defect formation in the mouse

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Pharmacologic evaluation of various metabolites and analogs of valproic acid: teratogenic potencies in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Valproic Acid-Induced Neural Tube Defects in Mouse and Human: Aspects of Chirality, Alternative Drug Development, Pharmacokinetics and Possible Mechanisms

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Protein kinase C inhibitors arrest the C6 glioma cell cycle at a mid-G1 phase restriction point: Implications for the antiproliferative action of valproate.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Expression of a neural cell adhesion molecule serum fragment is depressed in autism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Therapeutic levels of sodium valproate inhibit mitotic indices in cells of neural origin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

In vitro screening for anticonvulsant-induced teratogenesis: Structure-activity relationships in the barbiturate and branched chain carboxylic acid classes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Integrity of the homophilic binding site is required for the preferential localization of NCAM in intercellular contacts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Pharmacokinetic determinants of embryotoxicity in rats associated with organic acids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Inhibition of protein kinase C by alcohols and anaesthetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

The neural cell adhesion molecule (N-CAM) inhibits proliferation in primary cultures of rat astrocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Teratogenic effects on the neuroepithelium of the CD-1 mouse embryo exposed in utero to sodium valproate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

Antitumor activity of sodium valproate in cultures of human neuroblastoma cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

inferred from DOI database lookup

7 January 2021

based on heuristic

Effects of halothane on DNA synthesis and the presynthetic phase (G 1) in dividing fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0014-2999%2898%2900462-2

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-2999(98)00462-2

1 reference

12 July 2018

1 reference

12 July 2018